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Chromosome evolution screens recapitulate tissue-specific tumor aneuploidy patterns
Whole chromosome and arm-level copy number alterations occur at high frequencies in tumors, but their selective advantages, if any, are poorly...
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Characterizing genetic variation on the Z chromosome in Schistosoma japonicum reveals host-parasite co-evolution
BackgroundSchistosomiasis is a neglected tropical disease that afflicts millions of people worldwide; it is caused by Schistosoma, the only dioecious...
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Ring Chromosome 14
The exact physiopathology of ring chromosome 14 syndrome (RC14) (OMIM#616606) is currently unknown but it definitely does not rely only on the 14q...
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Ring Chromosome 12
The ring chromosome 12 (RC12) is an ultra-rare chromosomal disorder with only ten patients reported in the literature. Patients with RC12 often...
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Chromosome-level genomes of three key Allium crops and their trait evolution
Allium crop breeding remains severely hindered due to the lack of high-quality reference genomes. Here we report high-quality chromosome-level genome...
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Fragile, unfaithful and persistent Ys—on how meiosis can shape sex chromosome evolution
Sex-linked inheritance is a stark exception to Mendel’s Laws of Heredity. Here we discuss how the evolution of heteromorphic sex chromosomes (mainly...
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The Importance of Monitoring Non-clonal Chromosome Aberrations (NCCAs) in Cancer Research
Cytogenetic analysis has traditionally focused on the clonal chromosome aberrations, or CCAs, and considered the large number of diverse non-clonal...
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B Chromosome Variability in Plants and Animals under Extreme Environments
AbstractData on B chromosomes in populations of different systematic groups of plants and animals from extreme habitats, i.e., the range boundaries...
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Circulating DNA reveals a specific and higher fragmentation of the Y chromosome
Chromosome stability is a key point in genome evolution, particularly that of the Y chromosome. The Y chromosome loss in blood and tumor cells is...
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Observations on chromosome-specific sequencing for the construction of cross-species chromosome homology maps and its resolution of human:alpaca homology
BackgroundThe history of comparative chromosome map** is briefly reviewed, with discussion about the problem that occurs in chromosome painting...
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Profiling Chromosome Topological Features by Super-Resolution 3D Structured Illumination Microscopy
Three-dimensional structured illumination microscopy (3D-SIM) and fluorescence in situ hybridization on three-dimensional preserved cells (3D-FISH)...
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A Paradoxical Role for Somatic Chromosomal Mosaicism and Chromosome Instability in Cancer: Theoretical and Technological Aspects
Somatic chromosomal mosaicism, chromosome instability, and cancer are intimately linked together. Addressing the role of somatic genome variations...
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Sex chromosome evolution in frogs—helpful insights from chromosome painting in the genus Engystomops
The differentiation of sex chromosomes is thought to be interrupted by relatively frequent sex chromosome turnover and/or occasional recombination...
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Gene-poor Y-chromosomes substantially impact male trait heritabilities and may help shape sexually dimorphic evolution
How natural selection facilitates sexually dimorphic evolution despite a shared genome is unclear. The patrilineal inheritance of Y-chromosomes makes...
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Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements
Complex chromosome rearrangements, known as chromoanagenesis, are widespread in cancer. Based on large-scale DNA sequencing of human tumours, the...
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Evaluating Chromosome Instability and Genotoxicity Through Single Cell Quantitative Imaging Microscopy
Across eukaryotes, genome stability is essential for normal cell function, physiology, and species survival. Aberrant expression of key genes or...
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Genomes of multicellular algal sisters to land plants illuminate signaling network evolution
Zygnematophyceae are the algal sisters of land plants. Here we sequenced four genomes of filamentous Zygnematophyceae, including chromosome-scale...
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An update and frequency distribution of Y chromosome haplogroups in modern Japanese males
Japanese males belong to the Y chromosome C1a1, C2, D1a2a, D1a2a-12f2b, O1b2, O1b2a1a1, O2a2b1, and O2a1b haplogroups. Notably, the regional...
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Chromosome-scale genome assembly provides insights into rye biology, evolution and agronomic potential
Rye ( Secale cereale L.) is an exceptionally climate-resilient cereal crop, used extensively to produce improved wheat varieties via introgressive...
