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HDL and Cholesterol Ester Transfer Protein (CETP)
Cholesterol ester transfer protein (CETP) is important clinically and is one of the major targets in cardiovascular disease studies. With high...
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Prostate cancer cell proliferation is influenced by LDL-cholesterol availability and cholesteryl ester turnover
BackgroundProstate cancer growth is driven by androgen receptor signaling, and advanced disease is initially treatable by depleting circulating...
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Structural simplification and ester bond flip** lead to bis-benzodioxole derivatives as potential hypolipidemic and hepatoprotective agent
A series of bis-benzodioxole derivatives was designed, synthesized, and evaluated. These target compounds were designed through structure...
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Potential Use of the Cholesterol Transfer Inhibitor U18666A as a Potent Research Tool for the Study of Cholesterol Mechanisms in Neurodegenerative Disorders
Cholesterol is an essential component of mammalian cell membranes and a precursor for crucial signaling molecules. The brain contains the highest...
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C1q/Tumor Necrosis Factor-Related Protein-9 Enhances Macrophage Cholesterol Efflux and Improves Reverse Cholesterol Transport via AMPK Activation
Cholesterol efflux from foam cells in atherosclerotic plaques is crucial for reverse cholesterol transport (RCT), an important antiatherogenic event....
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ABCA1, ABCG1, and Cholesterol Homeostasis
Cholesterol is a major component of mammalian cell membranes and plays important structural and functional roles. However, excessive cholesterol...
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Role of acyl-coenzyme A: cholesterol transferase 1 (ACAT1) in retinal neovascularization
BackgroundWe have investigated the efficacy of a new strategy to limit pathological retinal neovascularization (RNV) during ischemic retinopathy by...
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Human cholesteryl ester transport protein transgene promotes macrophage reverse cholesterol transport in C57BL/6 mice and phospholipid transfer protein gene knockout mice
Cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP) belong to the same gene family. Liver-specific expression of CETP...
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Functional significance of cholesterol metabolism in cancer: from threat to treatment
Cholesterol is an essential structural component of membranes that contributes to membrane integrity and fluidity. Cholesterol homeostasis plays a...
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Disruption of cholesterol homeostasis triggers periodontal inflammation and alveolar bone loss
Oral diseases exhibit a significant association with metabolic syndrome, including dyslipidemia. However, direct evidence supporting this...
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Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis
BackgroundPersistent inflammatory response in the brain can lead to tissue damage and neurodegeneration. In Alzheimer's disease (AD), there is an...
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Advance in Multi-omics Research Strategies on Cholesterol Metabolism in Psoriasis
The skin is a complex and dynamic organ where homeostasis is maintained through the intricate interplay between the immune system and metabolism,...
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Fatty acids abrogate the growth-suppressive effects induced by inhibition of cholesterol flux in pancreatic cancer cells
BackgroundDespite therapeutic advances, the prognosis of pancreatic ductal adenocarcinoma (PDAC) remains extremely poor. Metabolic reprogramming is...
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Roles of peripheral lipoproteins and cholesteryl ester transfer protein in the vascular contributions to cognitive impairment and dementia
This narrative review focuses on the role of cholesteryl ester transfer protein (CETP) and peripheral lipoproteins in the vascular contributions to...
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Targeting cholesterol impairs cell invasion of all breast cancer types
BackgroundBreast cancer clinical outcome relies on its intrinsic molecular subtype and mortality is almost exclusively due to metastasis, whose...
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Intertwining of Retinoic Acid and Cholesterol Pathway and its Consequences in Leishmania donovani-Infected Macrophages
Visceral leishmaniasis (VL) is the most severe disease among other forms of leishmaniasis and results in a fatality in more than 90% of cases if left...
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Navigating the metabolic maze: anomalies in fatty acid and cholesterol processes in Alzheimer’s astrocytes
Alzheimer’s disease (AD) is the most common cause of dementia, and its underlying mechanisms have been a subject of great interest. The mainstream...
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CCDC92 promotes podocyte injury by regulating PA28α/ABCA1/cholesterol efflux axis in type 2 diabetic mice
Podocyte lipotoxicity mediated by impaired cellular cholesterol efflux plays a crucial role in the development of diabetic kidney disease (DKD), and...
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DNA methyltransferase 1 deficiency improves macrophage motility and wound healing by ameliorating cholesterol accumulation
Healing of the cutaneous wound requires macrophage recruitment at the sites of injury, where chemotactic migration of macrophages toward the wound is...
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Evaluation of Serum Paraoxonase, Myeloperoxidase, and HDL-Cholesterol Levels in Acute Myeloid Leukemia
Inflammation and oxidative stress play a significant role in the pathogenesis of acute myeloid leukemia. While myeloperoxidase carries pro-oxidant...