Search
Search Results
-
Significance of chitinase-3-like protein 1 in the pathogenesis of inflammatory diseases and cancer
Chitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein that mediates inflammation, macrophage polarization, apoptosis, and carcinogenesis....
-
Molecular identification of the chitinase genes in Aedes albopictus and essential roles of AaCht10 in pupal-adult transition
BackgroundAedes albopictus is an increasingly serious threat in public health due to it is vector of multiple arboviruses that cause devastating...
-
Chitin-mediated blockade of chitinase-like proteins reduces tumor immunosuppression, inhibits lymphatic metastasis and enhances anti-PD-1 efficacy in complementary TNBC models
BackgroundChitinase-like proteins (CLPs) play a key role in immunosuppression under inflammatory conditions such as cancer. CLPs are enzymatically...
-
Myeloid-specific deletion of chitinase-3-like 1 protein ameliorates murine diet-induced steatohepatitis progression
AbstractChitinase-3-like 1 protein (CHI3L1) is a secreted glycoprotein, strongly correlated with fibrosis severity in chronic liver diseases...
-
Regulatory role of Chitinase 3-like 1 gene in papillary thyroid carcinoma proved by integration analyses of single-cell sequencing with cohort and experimental validations
Papillary thyroid carcinoma (PTC) is one of the most common thyroid carcinomas. The gross extrathyroidal extension and extensive metastases of PTC...
-
3H-31, A Non-structural Protein of Heliothis virescens ascovirus 3h, Inhibits the Host Larval Cathepsin and Chitinase Activities
3h-31 of Heliothis virescens ascovirus 3h (HvAV-3h) is a highly conserved gene of ascoviruses. As an early gene of HvAV-3h, 3h-31 codes for a...
-
CSF CXCL13 and Chitinase 3-like-1 Levels Predict Disease Course in Relapsing Multiple Sclerosis
Several biomarkers from multiple sclerosis (MS) patients’ biological fluids have been considered to support diagnosis, predict disease course, and...
-
Endotoxin of Porphyromonas gingivalis amplifies the inflammatory response in hyperglycemia-induced zebrafish through a mechanism involving chitinase-like protein YKL-40 analogs
Porphyromonas gingivalis ( P. gingivalis ), a key pathogen in periodontal diseases, is also associated with hyperglycemia-associated systemic diseases,...
-
Comparative analysis of the allergenic characteristics and serodiagnostic potential of recombinant chitinase-like protein-5 and -12 from Sarcoptes scabiei
BackgroundScabies is caused by burrowing of the mite Sarcoptes scabiei into the stratum corneum. Currently, diagnosis via routine skin scra** is...
-
Combination protein biomarkers predict multiple sclerosis diagnosis and outcomes
Establishing biomarkers to predict multiple sclerosis diagnosis and prognosis has been challenging using a single biomarker approach. We hypothesised...
-
Frontal cortex chitinase and pentraxin neuroinflammatory alterations during the progression of Alzheimer’s disease
BackgroundChitinase 3-like 1 (CHI3L1), chitinase 3-like 2 (CHI3L2), and neuronal pentraxin II (NPTX2) are inflammatory biomarkers of Alzheimer’s...
-
Serum chitinase activity prognosticates metastasis of colorectal cancer
BackgroundThis study aimed to evaluate the value of chitinase activity in prognosticating the occurrence of metastasis in and prognosis of patients...
-
Scarless Baculovirus Genome Editing Using Lambda-Red Recombineering in E. coli
Baculoviruses are widely used for their potential as biological pesticide and as platform for the production of recombinant proteins and gene therapy...
-
Aspartyl protease in the secretome of honey bee trypanosomatid parasite contributes to infection of bees
BackgroundThe exoproteome, which consists of both secreted proteins and those originating from cell surfaces and lysed cells, is a critical component...
-
RNAi-mediated CHS-2 silencing affects the synthesis of chitin and the formation of the peritrophic membrane in the midgut of Aedes albopictus larvae
BackgroundMosquitoes are an important vector of viral transmission, and due to the complexity of the pathogens they transmit, vector control may be...
-
Characterization and bio-efficacy of entomopathogenic Beauveria associated with cuticle-degrading enzymes to restrain sucking pest Bemisia tabaci
The entomopathogenic Beauveria spp. were acquired from insect cadavers and soil rhizosphere of cotton, groundnut, and castor. Among Beauveria , five...
-
Identifying clinically useful biomarkers in neurodegenerative disease through a collaborative approach: the NeuroToolKit
BackgroundAlzheimer’s disease (AD) is a complex and heterogeneous disease, which requires reliable biomarkers for diagnosis and monitoring disease...
-
YKL-40 as an Inflammatory Biomarker in Nutrition
Low-grade inflammation plays an important role in several development processes of diseases. Chitinase-3-like protein 1 (YKL-40) is a glycoprotein,...
-
YKL-40 as an Inflammatory Biomarker in Nutrition
Low-grade inflammation plays an important role in several development processes of diseases. Chitinase-3-like protein 1 (YKL-40) is a glycoprotein,...