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Learning Relationships Between Chemical and Physical Stability for Peptide Drug Development
Purpose or ObjectiveChemical and physical stabilities are two key features considered in pharmaceutical development. Chemical stability is typically...
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Modulation of Solid-State Chemical Stability of Gabapentin by Pyridinecarboxylic Acid
PurposeGabapentin (GBP) is an anticonvulsant drug with poor chemical stability that is particularly sensitive to heat and mechanical stress, which...
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A study on the chemical stability of cholesterol-lowering drugs in concomitant simple suspensions with magnesium oxide
BackgroundDifficulty in taking solid medicines is a common issue particularly for the elderly because of a decline in swallowing function, also known...
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Chemical Carcinogens
This chapter is part of the Handbook of Cancer and Immunology, composed of various volumes addressing several aspects of different cancers, like...
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Chemical Biology of Extracellular Vesicles
During the initial phases of extracellular vesicle (EV) research, researchers faced many obstacles, including a lack of standard methods for the...
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Stability of Protein Pharmaceuticals: Recent Advances
There have been significant advances in the formulation and stabilization of proteins in the liquid state over the past years since our previous...
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Role of Charge Heterogeneity on Physical Stability of Monoclonal Antibody Biotherapeutic Products
PurposeChemical modifications in monoclonal antibodies can change hydrophobicity, charge heterogeneity as well as conformation, which eventually can...
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Optimization, Formulation, and Stability of Topical Rapamycin Used for Rare Tuberous Sclerosis Disease: from Ointment to Liposomes
IntroductionTopical rapamycin has been established as an effective and safe therapy for facial angiofibromas in tuberous sclerosis. Different...
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Luminescence-Based Techniques for KRAS Thermal Stability Monitoring
Various biochemical methods have been introduced to detect and characterize KRAS activity and interactions, from which the vast majority is based on...
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Impact of Processing Methods on the Physico-chemical Properties of Posaconazole Amorphous Solid Dispersions
Background & PurposeDifferent methods have been exploited to generate amorphous solid dispersions (ASDs) of poorly water-soluble drugs. However, the...
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Glycopeptide antibiotic drug stability in aqueous solution
Glycopeptide antimicrobials are a class of naturally occurring or semi-synthetic glycosylated products that have shown antibacterial activity against...
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Stability and Characterization of Protein- and Nucleotide-Based Therapeutics
Throughout the development process of protein or nucleotide-based therapeutics, a broad array of analytical techniques is applied on a routine basis...
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A Rapid 3-Day Excipient Screening Methodology and its Application in Identifying Chemical Stabilizers for Solid Formulations with Mixed Mechanisms of Degradation
This study outlines a practical approach for assessing chemical instability by heating the drug-excipient binary mixtures or multi-excipient...
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Mitigating Drug Stability Challenges Through Cocrystallization
Drug stability plays a significant role in the pharmaceutical industry from early-phase drug discovery to product registration as well as the entire...
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Applications of (Nano)encapsulated Natural Products by Physical and Chemical Methods
Natural products that originate from fungal, bacteria, plant, marine, and animal sources have a wide variety of applications. Numerous studies have...
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Physicochemical Stability of Space Medicines
Astronauts’ health and wellness maintenance in a unique, isolated, and extreme environment of space is a primary goal for a successful space mission....
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Development, Comparison, and Qualification of Predictive Pharmaceutical Stability Models Using Independent Statistical Tools
PurposeThe predictive modeling approach to assess long-term stability performance of pharmaceuticals by using short-term accelerated stability is of...
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Drug Stability and Chemical Kinetics
This book comprehensively reviews drug stability and chemical kinetics: how external factors can influence the stability of drugs, and the reaction...
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Stability of ascorbic acid in human aqueous humor
ObjectiveThe stability of ascorbic acid (AA) in the human aqueous humor (AqH) remains unclear. This study aimed to investigate the stability of AqH...
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Oligonucleotide therapeutics and their chemical modification strategies for clinical applications
BackgroundOligonucleotide therapeutics have emerged as a promising and dynamic class of pharmaceutical agents with remarkable potential for treating...
