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Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia–Reperfusion Injury Rats
Acute ischemic stroke (AIS) is a serious threat to human health. Following AIS, cerebral ischemia–reperfusion injury (CIRI) must be treated to...
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A high-resolution view of the heterogeneous aging endothelium
Vascular endothelial cell (EC) aging has a strong impact on tissue perfusion and overall cardiovascular health. While studies confined to the...
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Somatic BrafV600E mutation in the cerebral endothelium induces brain arteriovenous malformations
Current treatments of brain arteriovenous malformation (BAVM) are associated with considerable risks and at times incomplete efficacy. Therefore, a...
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Vascular Endothelium
The endothelium is strategically located at the interface between the blood flow and the vascular smooth muscle and other components of the vessel...
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Cortistatin deficiency reveals a dysfunctional brain endothelium with impaired gene pathways, exacerbated immune activation, and disrupted barrier integrity
BackgroundBrain activity governing cognition and behaviour depends on the fine-tuned microenvironment provided by a tightly controlled blood–brain...
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Erythrocyte–brain endothelial interactions induce microglial responses and cerebral microhemorrhages in vivo
BackgroundCerebral microhemorrhages (CMH) are associated with stroke, cognitive decline, and normal aging. Our previous study shows that the...
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ACVR1/ALK2-p21 signaling axis modulates proliferation of the venous endothelium in the retinal vasculature
The proliferation of the endothelium is a highly coordinated process to ensure the emergence, expansion, and homeostasis of the vasculature. While...
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Non-pharmacological interventions for vascular health and the role of the endothelium
The most common non-pharmacological intervention for both peripheral and cerebral vascular health is regular physical activity (e.g., exercise...
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RGD-coated polymeric microbubbles promote ultrasound-mediated drug delivery in an inflamed endothelium-pericyte co-culture model of the blood-brain barrier
Drug delivery to central nervous pathologies is compromised by the blood-brain barrier (BBB). A clinically explored strategy to promote drug delivery...
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Increased cerebral vascular resistance underlies preserved cerebral blood flow in response to orthostasis in humans on a high-salt diet
Cerebral blood flow autoregulation protects brain tissue from blood pressure variations and maintains cerebral perfusion pressure by changes in...
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Role of the endothelial reverse mode sodium-calcium exchanger in the dilation of the rat middle cerebral artery during hypoosmotic hyponatremia
A decrease in serum sodium ion concentration below 135 mmol L −1 is usually accompanied by a decrease in plasma osmolality (hypoosmotic hyponatremia)...
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Cerebral Vasoreactivity
Cerebral blood flow is mainly regulated by two mechanisms: cerebral autoregulation and neurovascular coupling (NVC). Cerebral autoregulation...
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Blocking P2RX7 Attenuates Ferroptosis in Endothelium and Reduces HG-induced Hemorrhagic Transformation After MCAO by Inhibiting ERK1/2 and P53 Signaling Pathways
Hyperglycemia is a risk factor for poor prognosis after acute ischemic stroke and promote the occurrence of hemorrhagic transformation (HT). The...
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The Effect of **nnao Shutong Capsules on Cerebral Circulation and Neurological and Motor Functions during Cerebral Infarction Recovery
AbstractThis study aimed to investigate the effects of **nnao shutong capsules (XSC) on the recovery of cerebral circulation and neurological and...
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Changes in Adhesion and the Expression of Adhesion Molecules in PBMCs after Aneurysmal Subarachnoid Hemorrhage: Relation to Cerebral Vasospasm
Aneurysmal subarachnoid hemorrhage (aSAH) is a neurovascular disease produced by extravasation of blood to the subarachnoid space after rupture of...
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The Role of Necroptosis in Cerebral Ischemic Stroke
Cerebral ischemia, also known as ischemic stroke, accounts for nearly 85% of all strokes and is the leading cause of disability worldwide. Due to...
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Dual Role of TRPV1 Channels in Cerebral Stroke: An Exploration from a Mechanistic and Therapeutic Perspective
Transient receptor potential vanilloid subfamily member 1 (TRPV1) has been strongly implicated in the pathophysiology of cerebral stroke. However,...
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Pathophysiology of reversible cerebral vasoconstriction syndrome
Reversible cerebral vasoconstriction syndrome (RCVS) is a complex neurovascular disorder being recognized during the past two decades. It is...
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Cerebral Small Vessel Disease: a Review of the Pathophysiological Mechanisms
Cerebral small vessel disease (cSVD) refers to the age-dependent pathological processes involving the brain small vessels and leading to vascular...
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Biomarkers of Brain Damage and Inflammation in Patients with Acute Cerebral Ischemia
Objectives. To study the pathogenetic and clinical significance of hypoxic brain damage and inflammatory mediators as factors in the development of...