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Subcortical White Matter Stroke in the Mouse: Inducing Injury and Tracking Cellular Proliferation
Here, we describe a method for inducing subcortical white matter stroke in mice, as well as tracking cellular proliferation through drinking water...
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Phosphoproteomic Analysis Reveals the Predominating Cellular Processes and the Involved Key Phosphoproteins Essential for the Proliferation of Toxoplasma gondii
PurposeTo explore the essential roles of phosphorylation in mediating the proliferation of T. gondii in its cell lytic life.
MethodsWe profiled the...
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AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma
BackgroundCurrently, multiple myeloma (MM) is still an incurable plasma cell malignancy in urgent need of novel therapeutic targets and drugs.
...
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Adult Glial Cell Proliferation and Neurogenesis
The nomenclature of stem and progenitor cells is reviewed. In the adult body, only glial cells and not neurons can proliferate. The glial cell with...
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p53-regulated lncRNAs in cancers: from proliferation and metastasis to therapy
Long non-coding RNAs (lncRNAs) have been identified as master gene regulators through various mechanisms such as transcription, translation, protein...
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Cholesterol reprograms glucose and lipid metabolism to promote proliferation in colon cancer cells
Hypercholesterolemia is often correlated with obesity which is considered a risk factor for various cancers. With the growing population of...
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Cancer as a Disease of Cell Proliferation
Evolutionary dynamics relates the growth and development of tumours to changes in rates of cell proliferation and cell death, and to their mutation...
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Cholesterol biosynthetic pathway induces cellular senescence through ERRα
Cellular senescence is a cell program induced by various stresses that leads to a stable proliferation arrest and to a senescence-associated...
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STK3 kinase activation inhibits tumor proliferation through FOXO1-TP53INP1/P21 pathway in esophageal squamous cell carcinoma
PurposeEsophageal squamous cell carcinoma (ESCC) is an aggressive disease with a poor prognosis, caused by the inactivation of critical cell growth...
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The TNFα/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis
Natural killer (NK) cells are predominant innate lymphocytes that initiate the early immune response during infection. NK cells undergo a metabolic...
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Repeated mild traumatic brain injury causes sex-specific increases in cell proliferation and inflammation in juvenile rats
Childhood represents a period of significant growth and maturation for the brain, and is also associated with a heightened risk for mild traumatic...
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Hyperthermia inhibits cellular function and induces immunogenic cell death in renal cell carcinoma
BackgroundIn recent years, hyperthermia has been widely applied as a novel strategy for cancer treatment due to its multiple antitumour effects. In...
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Spatiotemporal modulation of SMAD4 by HBx is required for cellular proliferation in hepatitis B-related liver cancer
PurposeHepatitis B virus (HBV) plays a crucial role in the progression of hepatocellular carcinoma (HCC). It is known that HBV-encoded X protein...
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EZH2-H3K27me3-mediated silencing of mir-139-5p inhibits cellular senescence in hepatocellular carcinoma by activating TOP2A
BackgroundEpigenetic alterations play an important role in hepatocellular carcinoma (HCC) development. Enhancer of zeste homolog 2 (EZH2) is a...
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The search for CDK4/6 inhibitor biomarkers has been hampered by inappropriate proliferation assays
CDK4/6 inhibitors are effective at treating advanced HR+ /HER2- breast cancer, however biomarkers that can predict response are urgently needed. We...
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Spatial genomic, biochemical and cellular mechanisms underlying meningioma heterogeneity and evolution
Intratumor heterogeneity underlies cancer evolution and treatment resistance, but targetable mechanisms driving intratumor heterogeneity are poorly...
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PCNA Staining of Retinal Cryosections to Assess Microglial/Macrophage Proliferation
Detection of the protein PCNA (proliferating cell nuclear antigen) is used to identify cells in the S phase of the cell cycle to indicate cellular...
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The role of cellular senescence in neurodegenerative diseases
Increasing evidence has revealed that cellular senescence drives NDs, including Alzheimer’s disease (AD) and Parkinson’s disease. Different senescent...
