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Effect of muscle fibre types and carnosine levels on the expression of carnosine-related genes in pig skeletal muscle
It is generally accepted that carnosine (β-alanyl- l -histidine) content is higher in glycolytic than in oxidative muscle fibres, but the underlying...
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Dual Effect of Carnosine on ROS Formation in Rat Cultured Cortical Astrocytes
Carnosine is composed of β-alanine and L-histidine and is considered to be an important neuroprotective agent with antioxidant, metal chelating, and...
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Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion
Tumor cells and surrounding immune cells undergo metabolic reprogramming, leading to an acidic tumor microenvironment. However, it is unclear how...
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Inhibitory Potential of Carnosine and Aminoguanidine Towards Glycation and Fibrillation of Albumin: In-vitro and Simulation Studies
Carnosine is beta-alanyl histidine, a dipeptide, endogenously produced in our body by the carnosine synthase enzyme. It is an antioxidant, thus...
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Anti-Aggregation and Antioxidant Properties of a New Derivative of Acetylsalicylic Acid and Carnosine
AbstractThe search for effective pharmaceutical agents which possess high antiaggregant and antioxidant activity, and simultaneously, lack negative...
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Effect of Carnosine on the Activity of Matrix Metalloproteinase-2 and Oxidative Stress in the Kidneys in Experimental Urate Nephrolithiasis
The effect of carnosine on MMP-2 activity and oxidative stress in the kidneys in experimental urate nephrolithiasis was studied. Urate...
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Muscular carnosine is a marker for cardiorespiratory fitness and cardiometabolic risk factors in men with type 1 diabetes
PurposeMuscle is an essential organ for glucose metabolism and can be influenced by metabolic disorders and physical activity. Elevated muscle...
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Trehalose–Carnosine Prevents the Effects of Spinal Cord Injury Through Regulating Acute Inflammation and Zinc(II) Ion Homeostasis
Spinal cord injury (SCI) leads to long-term and permanent motor dysfunctions, and nervous system abnormalities. Injury to the spinal cord triggers a...
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Carnosine quenches the reactive carbonyl acrolein in the central nervous system and attenuates autoimmune neuroinflammation
BackgroundMultiple sclerosis (MS) is a chronic autoimmune disease driven by sustained inflammation in the central nervous system. One of the...
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Swimming exercise versus L-carnosine supplementation for Alzheimer’s dementia in rats: implication of circulating and hippocampal FNDC5/irisin
Recent studies have suggested that irisin may act as a potential neurokine. Exercise and L-carnosine supplementation showed neuroprotective effects...
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The Effect of 4 Weeks of Strength Training and Beta-Alanine Supplementation on Anaerobic Power and Carnosine Level in Boxer Players
PurposeThe objective of this study was to investigate the effect of 4 weeks of strength training with beta-alanine supplementation on anaerobic power...
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Pulmonary inflammation, oxidative stress, and fibrosis in a mouse model of cholestasis: the potential protective properties of the dipeptide carnosine
Cholestasis is a clinical complication that primarily influences the liver. However, it is well known that many other organs could be affected by...
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Effect of Carnosine on the Course of Experimental Urate Nephrolithiasis
The prospect of using the antioxidant dipeptide carnosine for the treatment of urate nephrolithiasis was evaluated. Urate nephrolithiasis was modeled...
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Lipopolysaccharide exposure induces oxidative damage in Caenorhabditis elegans: protective effects of carnosine
BackgroundThe present study was designed to investigate the protective effects and mechanisms of carnosine on lipopolysaccharide (LPS)-induced injury...
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Carnosine suppresses human glioma cells under normoxic and hypoxic conditions partly via inhibiting glutamine metabolism
L -Carnosine (β-alanyl- L -histidine) is a naturally occurring dipeptide, which has shown broad-spectrum anticancer activity. But the anticancer...
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Mechanisms of Neuroprotective Action of Hesperetin and Carnosine in Focal Ischemia of the Brain in Rats
We compared the direct neuroprotective effect of minor food components, antioxidants hesperetin and carnosine, and analyzed their influence on the...
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A new derivative of acetylsalicylic acid and carnosine: synthesis, physical and chemical properties, biological activity
PurposeThe aim of this study was to create and assess biological activity of a new compound based on carnosine and acetylsalicylic acid (ASA) that...
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Durability of the moderate-to-heavy-intensity transition is related to the effects of prolonged exercise on severe-intensity performance
PurposePower output at the moderate-to-heavy-intensity transition decreases during prolonged exercise, and resilience to this has been termed...
