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Association of brain white matter lesions with arterial stiffness assessed by cardio-ankle vascular index. The Bei**g Vascular Disease Evaluation STudy (BEST)
Background—The association of brain white matter lesions with arterial stiffness, as assessed by the cardio-ankle vascular index, is not well...
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Role of sonic hedgehog signaling pathway in the regulation of ion channels: focus on its association with cardio-cerebrovascular diseases
Sonic hedgehog (SHH) signaling is vital for cell differentiation and proliferation during embryonic development, yet its role in cardiac, cerebral,...
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Mediterranean Diet and Neuro-Cognition: Focus on Alzheimer Disease
Given the rising incidence of cognitive impairment in population, especially in elderly persons with or without Neurodegenerative diseases such as...
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Effects of Exercise on Circulating Extracellular Vesicles in Cardiovascular Disease
The evidence that physical exercise has multiple beneficial effects and is essential to a healthy lifestyle is widely accepted for a long-time. The...
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COVID-19 Infection and Circulating Microparticles—Reviewing Evidence as Microthrombogenic Risk Factor for Cerebral Small Vessel Disease
Severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) due to novel coronavirus disease 2019 (COVID-19) has affected the global society in...
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Renin-Angiotensin System in Chronic Kidney Disease: Implications in Stroke Outcome
Stroke has an intricate pathophysiology and aggravation of that often leads to co-morbidities. Chronic kidney disease is devastating and plays an...
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The Effect of Skeletal Muscle-Pump on Blood Pressure and Postural Control in Parkinson's Disease
PurposeActivation of the calf (gastrocnemius and soleus) and tibialis anterior muscles play an important role in blood pressure regulation (via...
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Artificial Intelligence-Based Healthcare Industry 4.0 for Disease Detection Using Machine Learning Techniques
Smart Healthcare Solutions are prevailing in this technological evolving era of Industry 4.0. Healthcare Intelligence has been embedded within...
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Methods to evaluate vascular function: a crucial approach towards predictive, preventive, and personalised medicine
Endothelium, the gatekeeper of our blood vessels, is highly heterogeneous and a crucial physical barrier with the ability to produce vasoactive and...
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Data-Driven Exercise Medicine for Cardiovascular Disease
According to the Global Burden of Disease Study, in the past 20 years, cardiovascular disease (CVD) has consistently ranked as the leading cause of...
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A Ying-Yang Perspective on the Renin Angiotensin System in Cardiovascular Disease
The renin angiotensin systemRenin angiotensin system (RAS) plays a critical role in the regulation of the homeostatic control of arterial pressure,...
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Terpenes in the management of chronic kidney disease
Chronic kidney disease (CKD) is a chronic and progressive systemic condition that characterizes irreversible alterations in the kidneys’ function and...
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The role of carbonic anhydrase III and autophagy in type 2 diabetes with cardio-cerebrovascular disease
Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases among the elderly people. The T2DM increases the risk of...
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Chromatin modifiers in human disease: from functional roles to regulatory mechanisms
The field of transcriptional regulation has revealed the vital role of chromatin modifiers in human diseases from the beginning of functional...
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The therapeutic effect of mesenchymal stem cells in diabetic kidney disease
AbstractDiabetes mellitus (DM) often causes chronic kidney damage despite best medical practices. Diabetic kidney disease (DKD) arises from a complex...
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Effects of diosmin and crocin on metabolic syndrome-associated cardio-vascular complications in rats
This study aims to scrutinize the potential protective effect of diosmin and crocin against cardio-vascular complications attributed to metabolic...
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The gut-liver axis: emerging mechanisms and therapeutic approaches for nonalcoholic fatty liver disease and type 2 diabetes mellitus
Nonalcoholic fatty liver disease (NAFLD), more appropriately known as metabolic (dysfunction) associated fatty liver disease (MAFLD), a prevalent...
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Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease
Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading...
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Emerging Contributions of Endocrine Pathophysiology in Virus-Related Infectious Disease: Focus on the RAAS in COVID-19 and HIV
Aside from its traditional role in maintaining vascular hemodynamics and sodium balance, the renin–angiotensin–aldosterone system (RAAS) is...