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Risk factors for nosocomial rectal colonisation with carbapenem-resistant Gram-negative bacilli in children with haematological malignancies: a case-control study
BackgroundRectal colonisation with carbapenem-resistant Gram-negative bacilli (CR-GNB) may cause CR-GNB infection in children with haematological...
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Intraventricular or intrathecal polymyxin B for treatment of post-neurosurgical intracranial infection caused by carbapenem-resistant gram-negative bacteria: a 8-year retrospective study
PurposePost-neurosurgical intracranial infection caused by carbapenem-resistant gram-negative bacteria (CRGNB) is a life-threatening complication....
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Incidence of catheter-associated urinary tract infections by Gram-negative bacilli and their ESBL and carbapenemase production in specialized hospitals of Bahir Dar, northwest Ethiopia
BackgroundCatheter-associated urinary tract infections (CAUTIs) due to multidrug-resistant Gram-negative bacilli (GNB) is a common concern globally....
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Comparison of testing methods assessing the in vitro efficacy of the combination of aztreonam with avibactam on multidrug-resistant Gram-negative bacilli
BackgroundAztreonam-avibactam (ATM-AVI) combination shows promising effectiveness on most carbapenemase-producing Gram-negatives, yet standardized...
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Clinical outcomes and safety of polymyxin B in the treatment of carbapenem-resistant Gram-negative bacterial infections: a real-world multicenter study
BackgroundHigh morbidity and mortality due to carbapenem-resistant Gram-negative bacilli (CR-GNB) has led to the resurgence of polymyxin B (PMB) use...
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Real-world experience with meropenem/vaborbactam for the treatment of infections caused by ESBL-producing Enterobacterales and carbapenem-resistant Klebsiella pneumoniae
PurposeReal-world experience with meropenem/vaborbactam (M/V) is limited. Our aim is to report a clinical experience of M/V in the treatment of...
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Characterization of blaAFM-1-positive carbapenem-resistant strains isolated in Guangzhou, China
BackgroundCarbapenemase-producing makes a great contribution to carbapenem resistance in Gram-negative bacilli. Bla AFM-1 gene was first discovered...
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Predictive factors for sepsis by carbapenem resistant Gram-negative bacilli in adult critical patients in Rio de Janeiro: a case-case-control design in a prospective cohort study
BackgroundStudies have investigated risk factors for infections by specific species of carbapenem-resistant Gram-negative bacilli (CR-GNB), but few...
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In vitro activity of cefiderocol against carbapenem-resistant Acinetobacter baumannii carrying various β-lactamase encoding genes
ObjectivesThis study aimed to determine the in vitro efficacy of cefiderocol in carbapenem-resistant Acinetobacter baumannii (CRAB) isolates and...
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Evolution, control and success of combination therapy with Ampicilin-sulbactam/Ceftazidime-Avibactam during a Carbapenem-Resistant Acinetobacter baumannii outbreak in burn Intensive Care Unit
We present our findings on interpatient transmission, epidemic control measures, and the outcomes of a series of ten critically ill burn patients who...
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Effectiveness of tailored screening for multidrug-resistant organisms upon admission to an intensive care unit in the United Arab Emirates
BackgroundMultidrug-resistant organism (MDRO) screening may identify high-risk patients for MDRO infection and curb the spread of these resistant...
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Activity of ceftolozane/tazobactam and imipenem/relebactam against clinical gram-negative isolates from Czech Republic, Hungary, and Poland—SMART 2017–2020
Antimicrobial susceptibility was determined for clinical gram-negative isolates from Czech Republic, Hungary, and Poland, where published data for...
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New Cephalosporins: Fifth and Sixth Generations
New generation (5th) of cephalosporins have been introduced on the market over the last decade to combat methicillin-resistant Staphylococcus aureus...
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Carbapenem Resistance in Gram-Negative Bacilli: Mechanisms and Challenges
The emergence of carbapenem resistance within the Gram-negative bacilli including Enterobacteriaceae, Pseudomonas spp., and non-fermenters like...
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Combined selective culture and molecular methods for the detection of carbapenem-resistant organisms from fecal specimens
Detection of patients with intestinal colonization of carbapenem-resistant organisms (CRO), or more specifically carbapenemase-producing (CP) CRO,...
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Rapid detection of carbapenemase-producing organisms directly from blood cultures positive for Gram-negative bacilli
IntroductionThe rapid detection of carbapenemase-producing organisms (CPOs) directly from blood cultures (BCs) positive for Gram-negative bacilli...
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Current Reserve Drugs
The incidence of resistance development against antimicrobial agents is increasing in Gram-negative bacteria (GNB) worldwide. This has resulted into...
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A high prevalence of multi-drug resistant Gram-negative bacilli in a Nepali tertiary care hospital and associated widespread distribution of Extended-Spectrum Beta-Lactamase (ESBL) and carbapenemase-encoding genes
BackgroundMulti-drug resistance (MDR) and extensive-drug resistance (XDR) associated with extended-spectrum beta-lactamases (ESBLs) and...
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New Promising Antimicrobials in Development and Novel Approaches for Treatment of Infections
Despite the approval of several new antibiotics in the last several years, there is still an unmet need for treating multidrug-resistant bacteria,...
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Activity of ceftolozane/tazobactam and imipenem/relebactam against clinical isolates of Enterobacterales and Pseudomonas aeruginosa collected in Greece and Italy—SMART 2017–2021
PurposeThe current study evaluated the in vitro activities of ceftolozane/tazobactam (C/T), imipenem/relebactam (IMI/REL), and comparators against...