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Capillary rarefaction: a missing link in renal and cardiovascular disease?
Patients with chronic kidney disease (CKD) have an increased risk for cardiovascular morbidity and mortality. Capillary rarefaction may be both one...
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Persistent capillary rarefication in long COVID syndrome
BackgroundRecent studies have highlighted Coronavirus disease 2019 (COVID-19) as a multisystemic vascular disease. Up to 60% of the patients suffer...
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Retinal mid-peripheral capillary free zones are enlarged in cognitively unimpaired older adults at high risk for Alzheimer’s disease
BackgroundCompared to standard neuro-diagnostic techniques, retinal biomarkers provide a probable low-cost and non-invasive alternative for early...
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Assessment of the Rheological Properties of Biofluid Flow in Capillary Viscometer Channels
Results obtained during development of a capillary viscometer with the option of assessing the dynamic viscosity of small-volume biological samples...
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Hippocampal capillary pericytes in post-stroke and vascular dementias and Alzheimer’s disease and experimental chronic cerebral hypoperfusion
Neurovascular unit mural cells called ‘pericytes’ maintain the blood-brain barrier and local cerebral blood flow. Pathological changes in the...
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Post-COVID exercise intolerance is associated with capillary alterations and immune dysregulations in skeletal muscles
The SARS-CoV-2 pandemic not only resulted in millions of acute infections worldwide, but also in many cases of post-infectious syndromes,...
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22q11.2 Deletion-Associated Blood-Brain Barrier Permeability Potentiates Systemic Capillary Leak Syndrome Neurologic Features
We present a case study of a young male with a history of 22q11.2 deletion syndrome (22qDS), diagnosed with systemic capillary leak syndrome (SCLS)...
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Characterization of mRNA Lipid Nanoparticles by Electron Density Map** Reconstruction: X-ray Scattering with Density from Solution Scattering (DENSS) Algorithm
PurposeThis study aimed to test the feasibility of using Small Angle X-ray Scattering (SAXS) coupled with Density from Solution Scattering (DENSS)...
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Rapid assessment of 3-dimensional intra-tumor heterogeneity through cycling temperature capillary electrophoresis
ObjectiveTumors are heterogeneous three-dimensional masses populated by numerous cell types, including distinct sub-clones of cancerous cells....
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Modeling angiogenesis in the human brain in a tissue-engineered post-capillary venule
Angiogenesis plays an essential role in embryonic development, organ remodeling, wound healing, and is also associated with many human diseases. The...
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A novel somatic mutation in GNAQ in a capillary malformation provides insight into molecular pathogenesis
Sturge-Weber syndrome (SWS) is a sporadic, congenital, neuro-cutaneous disorder characterized by a mosaic, capillary malformation. SWS and...
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Optimization of Capillary-Based Western Blotting for MYO7A
Myosin VIIA (MYO7A)-associated Usher syndrome type 1B (USH1B) is a severe disorder that impacts the auditory, vestibular, and visual systems of...
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Oxygen flux from capillary to mitochondria: integration of contemporary discoveries
Resting humans transport ~ 100 quintillion (10 18 ) oxygen (O 2 ) molecules every second to tissues for consumption. The final, short distance (< 50 µm)...
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MRC1 and LYVE1 expressing macrophages in vascular beds of GNAQ p.R183Q driven capillary malformations in Sturge Weber syndrome
Sturge-Weber syndrome (SWS), a neurocutaneous disorder, is characterized by capillary malformations (CM) in the skin, brain, and eyes. Patients may...
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Modeling Gasotransmitter Availability to Brain Capillary Endothelial Cells with Ultrasound-sensitive Microbubbles
BackgroundVascular cognitive impairment and dementia results from blood components passing through disrupted blood brain barriers (BBBs). Current...
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Three dimensional evaluation of cerebrovascular density and branching in chronic traumatic encephalopathy
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to repetitive head impacts (RHI) and characterized by...
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Loss with ageing but preservation of frontal cortical capillary pericytes in post-stroke dementia, vascular dementia and Alzheimer’s disease
Cerebral pericytes are an integral component of the neurovascular unit, which governs the blood–brain barrier. There is paucity of knowledge on...
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Association of apoptosis-related variants to malaria infection and parasite density in individuals from the Brazilian Amazon
BackgroundIn malaria infection, apoptosis acts as an important immunomodulatory mechanism that leads to the elimination of parasitized cells, thus...
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Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells
The detailed mechanisms by which the transferrin receptor (TfR) and associated ligands traffic across brain capillary endothelial cells (BECs) of the...
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Quantifying Enzyme Activity and Gene Expression Within Single Cells Using a Multiplexed Capillary Electrophoresis Platform
To date, numerous chemical cytometry platforms have been developed to study a wide range of biologically relevant analytes in single cells by...