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The expression level of Neuronal Calcium Sensor 1 can predict the prognosis of cytogenetically normal AML
Acute myeloid leukemia (AML) is malignant clonal expansion of myeloid blasts with high heterogeneity and numerous molecular biomarkers have been...
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Interactions of Antibodies to the Gram-Negative Gastric Bacterium Helicobacter pylori with the Synaptic Calcium Sensor Synaptotagmin 5, Correlate to Impaired Vesicle Recycling in SiMa Human Neuroblastoma Cells
Due to molecular mimicry, maternal antibacterial antibodies are suspected to promote neurodevelopmental changes in the offspring that finally can...
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NCS-1 protein regulates TRPA1 channel through the PI3K pathway in breast cancer and neuronal cells
The physical and functional interaction between transient receptor potential channel ankyrin 1 (TRPA1) and neuronal calcium sensor 1 (NCS-1) was...
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Neurochemistry of the mammillary body
The mammillary body (MB) is a component of the extended hippocampal system and many studies have shown that its functions are vital for mnemonic...
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CaV1.1 Calcium Channel Signaling Complexes in Excitation–Contraction Coupling: Insights from Channelopathies
In skeletal muscle, excitation–contraction (EC) coupling relies on the mechanical coupling between two ion channels: the L-type voltage-gated calcium...
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Intracellular Ca2+ Regulation
A plethora of cellular functions including vasoconstriction and vasodilatation are regulated by calcium (Ca2+) ion and the cytosolic Ca2+...
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Calcium Sensors of Neurotransmitter Release
Calcium (Ca2+) plays a critical role in triggering all three primary modes of neurotransmitter release (synchronous, asynchronous, and spontaneous)....
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Current Understanding of the Role of Neuronal Calcium Sensor 1 in Neurological Disorders
Neuronal calcium sensor 1 (NCS-1) is a high-affinity calcium-binding protein and its ubiquitous expression in the nervous system implies a wide range...
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Therapeutic potential of endoplasmic reticulum stress inhibitors in the treatment of diabetic peripheral neuropathy
Endoplasmic stress response, the unfolded protein response (UPR), is a homeostatic signaling pathway comprising transmembrane sensors that get...
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Blocking P2X7 by intracerebroventricular injection of P2X7-specific nanobodies reduces stroke lesions
BackgroundPrevious studies have demonstrated that purinergic receptors could be therapeutic targets to modulate the inflammatory response in multiple...
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AMP-activated kinase regulates porcine reproductive and respiratory syndrome virus infection in vitro
Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically important pathogen in the pig industry worldwide. Many viruses...
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Regulation of retinal membrane guanylyl cyclase (RetGC) by negative calcium feedback and RD3 protein
This article presents a brief overview of the main biochemical and cellular processes involved in regulation of cyclic GMP production in...
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Identification of neural oscillations and epileptiform changes in human brain organoids
Brain organoids represent a powerful tool for studying human neurological diseases, particularly those that affect brain growth and structure....
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Hippocalcin-like 1 is a key regulator of LDHA activation that promotes the growth of non-small cell lung carcinoma
BackgroundHippocalcin-like 1 (HPCAL1), a neuronal calcium sensor protein family member, has been reported to regulate cancer growth. As yet, however,...
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Venom-Derived Peptides Inhibiting Voltage-Gated Sodium and Calcium Channels in Mammalian Sensory Neurons
Pain management is a serious worldwide problem that affects the physical and mental health of all affected humans. As an alternative to opioids,...
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Visualization of Glutamatergic Neurotransmission in Diverse Model Organisms with Genetically Encoded Indicators
Glutamate is the principal excitatory neurotransmitter, and occasionally subserves inhibitory roles, in the vertebrate nervous system. Glutamatergic...
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Conservation of Ligand Binding Between Voltage-Gated Sodium and T-Type Calcium Channels
In vertebrates, two types of ion channels are responsible for amplifying electrical signals and facilitating neurotransmission: voltage-gated sodium...
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CCL2 facilitates spinal synaptic transmission and pain via interaction with presynaptic CCR2 in spinal nociceptor terminals
Previous studies have shown that CCL2 may cause chronic pain, but the exact mechanism of central sensitization is unclear. In this article, we...
