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Calcium Buffering: Models of

Hartmut Schmidt in Encyclopedia of Computational Neuroscience

Reference work entry 2022

Mitochondrial Calcium Waves by Electrical Stimulation in Cultured Hippocampal Neurons

Mitochondria are critical to cellular Ca ²⁺ homeostasis via the sequestering of cytosolic Ca ²⁺ in the mitochondrial matrix. Mitochondrial Ca ²⁺...

Yunkyung Eom, Sung Rae Kim, ... Sung Hoon Lee in Molecular Neurobiology

Article 23 November 2023

Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury

Background

Traumatic brain injury (TBI) is characterized by massive changes in neuronal excitation, from acute excitotoxicity to chronic hyper- or...

Albrecht Fröhlich, Florian Olde Heuvel, ... Francesco Roselli in Journal of Neuroinflammation

Article Open access 19 November 2022

Aging reduces calreticulin expression and alters spontaneous calcium signals in astrocytic endfeet of the mouse dorsolateral striatum

Aging-related impairment of the blood brain barrier (BBB) and neurovascular unit (NVU) increases the risk for neurodegeneration. Among various cells...

Sara M. Zarate, Taylor E. Huntington, ... Rahul Srinivasan in npj Aging

Article Open access 31 March 2023

The importance of kidney calcium handling in the homeostasis of extracellular fluid calcium

Extracellular fluid calcium concentration must be maintained within a narrow range in order to sustain many biological functions, encompassing muscle...

Caroline Prot-Bertoye, Loïc Lievre, Pascal Houillier in Pflügers Archiv - European Journal of Physiology

Article 16 July 2022

Cytoplasmic Calcium Buffering: An Integrative Crosstalk

Calcium (Ca2+) buffering is part of an integrative crosstalk between different mechanisms and elements involved in the control of free Ca2+ ions...

Juan A. Gilabert in Calcium Signaling

Chapter 2020

Effect of disturbances in neuronal calcium and IP3 dynamics on β-amyloid production and degradation

Overproduction and accumulation of β-amyloid and its improper clearance can cause neurotoxicity leading to Alzheimer’s disease. The production and...

Anand Pawar, Kamal Raj Pardasani in Cognitive Neurodynamics

Article 17 May 2022

The T-type calcium channelosome

T-type calcium channels perform crucial physiological roles across a wide spectrum of tissues, spanning both neuronal and non-neuronal system. For...

Norbert Weiss, Gerald W. Zamponi in Pflügers Archiv - European Journal of Physiology

Article 01 December 2023

Computational model of the spatiotemporal synergetic system dynamics of calcium, IP₃ and dopamine in neuron cells

The functioning of several cellular processes in neuron cells relies on the interplay between multiple systems, such as calcium ([Ca ²⁺]), inositol 1,...

Anand Pawar, Kamal Raj Pardasani in Cognitive Neurodynamics

Article 06 May 2024

Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration

Glutamate is the most commonly engaged neurotransmitter in the mammalian central nervous system, acting to mediate excitatory neurotransmission....

Manish Verma, Britney N. Lizama, Charleen T. Chu in Translational Neurodegeneration

Article Open access 25 January 2022

Use of Optical Probes for Visualizing Intracellular Calcium and Recording Action Potentials in Neurons

To date, intracellular calcium reporters are the most commonly used optical probes for detecting neuron activity. Synthetic low molecular weight and...

E. S. Nikitin, M. V. Roshchin, ... P. M. Balaban in Neuroscience and Behavioral Physiology

Article 01 October 2022

Roles and Sources of Calcium in Synaptic Exocytosis

Calcium ions (Ca2+) play a critical role in triggering neurotransmitter release. The rate of release is directly related to the concentration of Ca2+...

Zhao-Wen Wang, Sadaf Riaz, Longgang Niu in Molecular Mechanisms of Neurotransmitter Release

Chapter 2023

Neuronal Store-Operated Calcium Channels

The endoplasmic reticulum (ER) is the major intracellular calcium (Ca ²⁺) storage compartment in eukaryotic cells. In most instances, the mobilization...

Alexandre Bouron in Molecular Neurobiology

Article 28 April 2023

Calcium Waves, Models of

M. Saleet Jafri, Aman Ullah in Encyclopedia of Computational Neuroscience

Reference work entry 2022

Extracellular CIRP Induces Calpain Activation in Neurons via PLC-IP₃-Dependent Calcium Pathway

Abnormal calcium homeostasis, activation of protease calpain, generation of p25 and hyperactivation of cyclin-dependent kinase 5 (Cdk5) have all been...

Archna Sharma, Ezgi Sari, ... ** Wang in Molecular Neurobiology

Article 28 February 2023

Dissolution of a Biopharmaceutics Classification System Class II Free Acid from Immediate Release Tablets Containing a Microenvironmental pH Modulator: Comparison of a Biorelevant Bicarbonate Buffering System with Phosphate Buffers

Poor water dissolution of active pharmaceutical ingredients (API) limits the rate of absorption from the gastrointestinal tract. Increasing the pH of...

Dorota Haznar-Garbacz, Dagmara Hoc, ... Michał Romański in AAPS PharmSciTech

Article Open access 26 July 2022

Regulation of Calcium in the Cerebellum

Ca2+ is an important ion in central nervous system (CNS) biology, where it plays a critical role in the basic functions of neurons, glia, and other...

Donna L. Gruol in Essentials of Cerebellum and Cerebellar Disorders

Chapter 2023

Calcium signaling from sarcoplasmic reticulum and mitochondria contact sites in acute myocardial infarction

Acute myocardial infarction (AMI) is a serious condition that occurs when part of the heart is subjected to ischemia episodes, following partial or...

Esther Densu Agyapong, Gaia Pedriali, ... Giampaolo Morciano in Journal of Translational Medicine

Article Open access 09 June 2024