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Interplay between androgen and CXCR4 chemokine signaling in myelin repair
In men, reduced levels of testosterone are associated with the prevalence and progression of multiple sclerosis (MS), a chronic and disabling...
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CXCR4 overexpression in chronic lymphocytic leukemia associates with poorer prognosis: A prospective, single-center, observational study
Controversial data have been reported on the prognostic value of C-X-C motif chemokine receptor 4 (CXCR4) in chronic lymphocytic leukemia (CLL). This...
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CXCL12–CXCR4 Axis in Cancer Metastasis
The malignancy that leads to the most fatalities is characterized by metastasis. Due to continually develo** research in the biology of cancer as...
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Targeting CXCR4 impaired T regulatory function through PTEN in renal cancer patients
BackgroundTregs trafficking is controlled by CXCR4. In Renal Cell Carcinoma (RCC), the effect of the new CXCR4 antagonist, R54, was explored in...
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Demethylation in promoter region of severely damaged hepatocytes enhances chemokine receptor CXCR4 gene expression
The liver is known to possess remarkable regenerative potential, but persistent inflammation or severe acute injury can lead to liver fibrosis and...
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Cooperative interactions between neurotrophin receptors and CXCR4 regulate macrophage phenotype and susceptibility to activation by HIV
Neural damage due to inflammatory activation of macrophages and microglia is a consequence of HIV infection that leads to cognitive dysfunction. The...
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Targeting CXCR4 abrogates resistance to trastuzumab by blocking cell cycle progression and synergizes with docetaxel in breast cancer treatment
BackgroundAlthough trastuzumab and other HER2-targeted therapies have significantly improved survival in patients with HER2 overexpressed or...
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Activation of the CXCR4 Receptor by Chemokine CXCL12 Increases the Excitability of Neurons in the Rat Central Amygdala
Primarily regarded as immune proteins, chemokines are emerging as a family of molecules serving neuromodulatory functions in the develo** and adult...
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CXCR4 as possible druggable target linking inflammatory bowel disease and Parkinson's disease
Parkinson’s disease (PD) is a chronic, progressive, and second most prevalent neurological disorder affecting the motor system. It has been found...
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Tumour inhibitory activity on pancreatic cancer by bispecific nanobody targeting PD-L1 and CXCR4
Background:Antibodies and derivative drugs targeting immune checkpoints have been approved for the treatment of several malignancies, but there are...
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Maintenance of Epstein-Barr virus latency through interaction of LMP2A with CXCR4
Epstein-Barr virus (EBV) belongs to the subfamily Gammaherpesvirinae and was the first human tumor virus to be discovered. The global rate of EBV...
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Genotype–phenotype correlations in WHIM syndrome: a systematic characterization of CXCR4WHIM variants
Warts, hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome is a rare primary immunodeficiency predominantly caused by heterozygous...
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PIM3 kinase promotes tumor metastasis in hepatoblastoma by upregulating cell surface expression of chemokine receptor cxcr4
Patients presenting with metastatic hepatoblastoma have limited treatment options and survival rates as low as 25%. We previously demonstrated that...
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CXCR4 enhances the inhibitory effects of bone mesenchymal stem cells on lung cell apoptosis in a rat model of smoking-induced COPD
Chronic obstructive pulmonary disease is the 3rd leading cause of death worldwide, and the available treatments are unsatisfactory, resulting in a...
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The clinicopathological and prognostic value of CXCR4 expression in patients with lung cancer: a meta-analysis
BackgroundThe C-X-C chemokine receptor 4 (CXCR4) has been suggested to play an important role in several types of cancers and is related to...
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MicroRNA-1 attenuates the growth and metastasis of small cell lung cancer through CXCR4/FOXM1/RRM2 axis
BackgroundSmall cell lung cancer (SCLC) is an aggressive lung cancer subtype that is associated with high recurrence and poor prognosis. Due to lack...
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Comparative evaluation of somatostatin and CXCR4 receptor expression in different types of thyroid carcinoma using well-characterised monoclonal antibodies
BackgroundPapillary and follicular thyroid carcinomas can be treated surgically and with radioiodine therapy, whereas therapeutic options for...
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Regorafenib Reverses Temozolomide-Induced CXCL12/CXCR4 Signaling and Triggers Apoptosis Mechanism in Glioblastoma
Temozolomide (TMZ) monotherapy is known to be insufficient for resistant/relapsed glioblastoma (GBM), thus seeking a sensitization agent for TMZ is...
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CXCR4-targeted nanotoxins induce GSDME-dependent pyroptosis in head and neck squamous cell carcinoma
BackgroundTherapy resistance, which leads to the development of loco-regional relapses and distant metastases after treatment, constitutes one of the...
