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Association of TERT-CLPTM1L and 8q24 Common Genetic Variants with Gallbladder Cancer Susceptibility and Prognosis in North Indian Population
Gallbladder carcinoma (GBC) is one of the common malignancy of the biliary tract. Several genome wide and candidate gene studies have reported...
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Skin Cancer: An Overview
Skin cancer is one of the most prevalent forms of cancer, comprising two major types: non-melanoma and melanoma. The major cause behind development...
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Skin Cancer: An Overview
Skin cancer is one of the most prevalent forms of cancer, comprising two major types: non-melanoma and melanoma. The major cause behind development...
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Epidemiology of nasopharyngeal carcinoma: current insights and future outlook
Nasopharyngeal carcinoma (NPC) is characterised by its remarkable geographical and ethnic distribution. The interplay between genetic susceptibility,...
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Susceptibility loci for pancreatic cancer in the Brazilian population
BackgroundPancreatic adenocarcinoma (PA) is a very aggressive cancer and has one of the poorest prognoses. Usually, the diagnosis is late and...
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Diagnostic-Prognostic Biomarkers and Their Clinical Implication in Breast Cancer
Breast cancer (BC) is a complex disease that continues to affect global cancer fatalities with its high incidence rate. Hence, BC requires...
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Assessing a single SNP located at TERT/CLPTM1L multi-cancer risk region as a genetic modifier for risk of pancreatic cancer and melanoma in Dutch CDKN2A mutation carriers
Carriers of pathogenic variants in CDKN2A have a 70% life-time risk of develo** melanoma and 15–20% risk of develo** pancreatic cancer (PC). In...
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Diagnostic-Prognostic Biomarkers and Their Clinical Implication in Breast Cancer
Breast cancer (BC) is a complex disease that continues to affect global cancer fatalities with its high incidence rate. Hence, BC requires...
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TERT Gene rs2736100 and rs2736098 Polymorphisms are Associated with Increased Cancer Risk: A Meta-Analysis
Abnormal telomerase activity plays a key role in the development of carcinogenesis. The variants rs2736100 and rs2736098 of the telomerase reverse...
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DNA methylation QTL map** across diverse human tissues provides molecular links between genetic variation and complex traits
Studies of DNA methylation (DNAm) in solid human tissues are relatively scarce; tissue-specific characterization of DNAm is needed to understand its...
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Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions
Here, in a multi-ancestry genome-wide association study meta-analysis of kidney cancer (29,020 cases and 835,670 controls), we identified 63...
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The associations of TERT-CLPTM1L variants and TERT mRNA expression with the prognosis of early stage non-small cell lung cancer
Lung cancer is the leading cause of cancer-related death in the world. Several genome-wide association studies (GWAS) have identified TERT-CLPTM1L as...
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Mediation by differential DNA methylation of known associations between single nucleotide polymorphisms and bladder cancer risk
BackgroundThough bladder cancer has been the subject of many well-powered genome-wide association studies, the mechanisms involving...
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Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus
Endometriosis, polycystic ovary syndrome (PCOS) and uterine fibroids have been proposed as endometrial cancer risk factors; however, disentangling...
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The rationale for treating uveal melanoma with adjuvant melatonin: a review of the literature
BackgroundUveal melanoma is a rare form of cancer with high mortality. The incidence of metastases is attributed to early seeding of micrometastases...
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A global overview of genetically interpretable multimorbidities among common diseases in the UK Biobank
BackgroundMultimorbidities greatly increase the global health burdens, but the landscapes of their genetic risks have not been systematically...
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Telomeres and telomerase: three decades of progress
Many recent advances have emerged in the telomere and telomerase fields. This Timeline article highlights the key advances that have expanded our...
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The Association of Single Nucleotide Polymorphisms with Cancer Risk
Cancer is the second leading cause of death and there were 17.5 million cancer cases and 8.7 million deaths worldwide in 2015. Although cancer...
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X-chromosome association study reveals genetic susceptibility loci of nasopharyngeal carcinoma
BackgroundThe male predominance in the incidence of nasopharyngeal carcinoma (NPC) suggests the contribution of the X chromosome to the...
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Discovery of common and rare genetic risk variants for colorectal cancer
To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed...
