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Lappaconitine sulfate inhibits proliferation and induces mitochondrial-mediated apoptosis via regulating PI3K/AKT/GSK3β signaling pathway in HeLa cells
Lappaconitine (LA), a diterpenoid alkaloid extracted from the root of Aconitum sinomontanum Nakai, exhibits broad pharmacological effects, including...
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3'-[18F]fluoro-3'-deoxythymidine ([18F]FLT) Positron Emission Tomography as an In Vivo Biomarker of inhibition of CDK 4/6-Rb pathway by Palbociclib in a patient derived bladder tumor
BackgroundSeveral new generation CDK4/6 inhibitors have been developed and approved for breast cancer therapy in combination with endocrine...
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Applications of Molecular Biology and Biomedical Advances in Ocular Oncology
Retinoblastoma, one of the first cancers for which a genetic basis has been explained, has been the prototype of genetic cancers. In addition to the...
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CDk Inhibitor for Treatment of Breast Cancer
A complicated interaction of Cyclins and cyclin-dependent kinases (CDKs) drives the mammalian cell cycle and one of the main causes or hallmarks of...
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Cdk4/Cdk6 Dysregulation in Estrogen-Positive Receptor Breast Cancers
Breast cancer (BC) is a worldwide threat to women and it is increasing day by day. There are various types of breast cancers like ER+, HER2+/−,...
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Cell Cycle and Cancer
Cancer is the second leading cause of mortality worldwide. It is an anomalous condition in which cell growth bypasses all the normal restraints on...
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Uncovering Cell Cycle Dysregulations and Associated Mechanisms in Cancer and Neurodegenerative Disorders: A Glimpse of Hope for Repurposed Drugs
The cell cycle is the sequence of events orchestrated by a complex network of cell cycle proteins. Unlike normal cells, mature neurons subsist in a...
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Introduction to Cell Cycle and Its Regulators
The extremely complicated chain of associations among cytokines, proteins, enzymes, and cell cycle signaling pathways orchestrates cell cycle...
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Novel CDK Inhibitors in Breast Cancer
Breast cancer is thought to be the most frequent kind of cancer in women globally. It is crucial to comprehend the biology of this tumor before...
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Nontoxic Natural Products as Regulators of Tumor Suppressor Gene Function
Cancer is a multifactorial disorder caused by the accumulation of multiple genetic, epigenetic lesions or its combination on cancer critical genes,...
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Inhibition of the HIF-1 Survival Pathway as a Strategy to Augment Photodynamic Therapy Efficacy
Photodynamic therapy (PDT) is a non-to-minimally invasive treatment modality that utilizes photoactivatable drugs called photosensitizers to disrupt...
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Molecular Subtypes of Breast Cancer and CDk Dysregulation
Breast carcinoma comprises a group of diseases with specific clinical, molecular and histopathologic properties. Tumours have traditionally been...
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CDK Dysregulation in Breast Cancer: A Bioinformatics Analysis
Breast cancer is one of the most common types of malignancy diagnosed among females worldwide. Due to its heterogenous nature, the type of treatment...
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Cell Cycle Dysregulation in Breast Cancer
Cancer, a condition characterized by abnormal cell growth, is closely linked to the cell cycle. In reaction to mitogenic cues, all malignancies...
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Imperatorin induces autophagy and G0/G1 phase arrest via PTEN-PI3K-AKT-mTOR/p21 signaling pathway in human osteosarcoma cells in vitro and in vivo
BackgroundOsteosarcoma is the third most common cancer in adolescence and the first common primary malignant tumor of bone. The long-term prognosis...
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Cell Cycle, DNA Damage Repair Systems, and Impact of Redox Regulation in Cancer
This chapter entitled “Cell Cycle, DNA Damage Repair Systems, and Impact of Redox Regulation in Cancer” introduces the cell cycle components in...
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Cell Cycle Arrest Biomarkers in the Intensive Care Unit
AKI is a clinical syndrome mainly manifested as a sharp decline in renal function, which is a common complication in the ICU and is characterized by...
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Targeting CDKs with Other Chemotherapeutic Drugs: A Combinatorial Approach
Among the various breast cancer subtypes, hormone receptor positive (HR+) breast cancer is frequently diagnosed with nearly thousands of patients...
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Molecular Pathways in Breast Cancer Chemoresistance
Chemoresistance is one of the determinants of breast cancer (BrCA) prognosis. Chemoresistance leads to recurrence and metastasis that causes adverse...
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A cell cycle centric view of tumour dormancy
Tumour dormancy and recurrent metastatic cancer remain the greatest clinical challenge for cancer patients. Dormant tumour cells can evade treatment...
