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Properties of Nav1.8ChR2-positive and Nav1.8ChR2-negative afferent mechanoreceptors in the hindpaw glabrous skin of mice
Nav1.8-positive afferent fibers are mostly nociceptors playing a role in mediating thermal and mechanical pain, but mechanoreceptors within these...
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Piezo1 channel activation facilitates baroreflex afferent neurotransmission with subsequent blood pressure reduction in control and hypertension rats
Mechanosensitive cation channels such as Piezo1 and Piezo2 are activated by mechanical force like a starched wall of the aorta while blood pressure...
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A biophysically comprehensive model of urothelial afferent neurons: implications for sensory signalling in urinary bladder
The urothelium is the innermost layer of the bladder wall; it plays a pivotal role in bladder sensory transduction by responding to chemical and...
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Differential frequency-dependent reflex summation of the aortic baroreceptor afferent input
Reflex summation in the expression of left and right aortic baroreflex control of hemodynamic functions was investigated. In anesthetized...
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Afferent neurons of the kidney with impaired firing pattern in inflammation – role of sodium currents?
Peripheral neurons with renal afferents exhibit a predominantly tonic firing pattern of higher frequency that is reduced to low frequencies (phasic...
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Translating Colonic Sensory Afferent Peripheral Mechanosensitivity into the Spinal Cord Dorsal Horn
Sensory afferent signalling from the colon and rectum is relayed into the spinal cord. The spinal cord contains distinct neurocircuits that control...
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Responses of cutaneous C-fiber afferents and spinal microglia after hindlimb cast immobilization in rats
Previous studies have shown that persistent limb immobilization using a cast increases nociceptive behavior to somatic stimuli in rats. However, the...
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Estrogen-dependent depressor response of melatonin via baroreflex afferent function and intensification of PKC-mediated Nav1.9 activation
Recent studies suggest that melatonin (Mel) plays an important role in the regulation of blood pressure (BP) via the aortic baroreflex pathway. In...
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Vestibular Nuclei and Their Cerebellar Connections
The vestibular nuclei and the vestibulocerebellum comprise the anatomical crossroads where primary vestibular information is collected, stored, and...
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Axonal Trajectories of Single Climbing and Mossy Fiber Neurons in the Cerebellar Cortex and Nucleus
A major factor in determining the function of a particular cerebellar cortical region depends upon its afferent and efferent connections. Two...
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Immunohistochemical characterization of transient receptor potential vanilloid types 2 and 1 in a trinitrobenzene sulfonic acid-induced rat colitis model with visceral hypersensitivity
Transient receptor potential vanilloid type 2 (TRPV2) and type 1 (TRPV1) are originally identified as heat-sensitive TRP channels. We compared the...
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Neurogenic substance P—influences on action potential production in afferent neurons of the kidney?
We recently showed that a substance P (SP)–dependent sympatho-inhibitory mechanism via afferent renal nerves is impaired in mesangioproliferative...
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Stimulation parameters for directional vagus nerve stimulation
BackgroundAutonomic nerve stimulation is used as a treatment for a growing number of diseases. We have previously demonstrated that application of...
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Zones and Stripes
The cerebellar cortex is built around different classes of Purkinje cell, which form distinct anterior–posterior transverse zones, each of which is...
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The Biomechanics of Distal Colon and Rectum and Its Relevance to Visceral Pain
Visceral pain differs significantly from cutaneous pain in both its clinical and psychophysical manifestations. There is a prominent “mechanical”...
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Differentiated somatic gene expression is triggered in the dorsal hippocampus and the anterior retrosplenial cortex by hippocampal synaptic plasticity prompted by spatial content learning
Hippocampal afferent inputs, terminating on proximal and distal subfields of the cornus ammonis (CA), enable the functional discrimination of ‘what’...
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Responses of Primary Afferent Fibers to Acupuncture-Like Peripheral Stimulation at Different Frequencies: Characterization by Single-Unit Recording in Rats
The pain-relieving effect of acupuncture is known to involve primary afferent nerves (PANs) via their roles in signal transmission to the CNS. Using...
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Vestibulocerebellar Functional Connections
The vestibular system projects onto the cerebellum via three major pathways that are composed of primary and secondary vestibular mossy fiber...
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Cerebellar Epigenetics: Transcription of microRNAs in Purkinje Neurons as an Approach to Neuronal Plasticity
Cerebellar plasticity is often investigated using brief electrical coactivation of climbing and parallel fiber pathways to evoke Long Term Depression...
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Neurochemical mechanism of muscular pain: Insight from the study on delayed onset muscle soreness
We reviewed fundamental studies on muscular pain, encompassing the characteristics of primary afferent fibers and neurons, spinal and thalamic...
