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Zebrafish gonad mutant models reveal neuroendocrine mechanisms of brain sexual dimorphism and male mating behaviors of different brain regions
BackgroundSexually dimorphic mating behaviors differ between sexes and involve gonadal hormones and possibly sexually dimorphic gene expression in...
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Sexual dimorphism in the murine model of extraparenchymal neurocysticercosis
Neurocysticercosis is a heterogeneous disease, and the patient’s sex seems to play a role in this heterogeneity. Hosts’ sexual dimorphism in...
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An emerging link between lncRNAs and cancer sex dimorphism
The prevalence and progression of cancer differ in males and females, and thus, sexual dimorphism in tumor development directly impacts clinical...
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Investigating sexual dimorphism in human brain structure by combining multiple indexes of brain morphology and source-based morphometry
Computational morphometry of magnetic resonance images represents a powerful tool for studying macroscopic differences in human brains. In the...
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Multimodal Image Analysis of Sexual Dimorphism in Develo** Childhood Brain
It is well known that there exist great differences in human brain anatomy and functions between males and females. With the development of...
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Temporo-basal sulcal connections: a manual annotation protocol and an investigation of sexual dimorphism and heritability
The temporo-basal region of the human brain is composed of the collateral, the occipito-temporal, and the rhinal sulci. We manually rated (using a...
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Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases
Metabolic diseases, such as obesity, metabolic syndrome (MetS) and type 2 diabetes (T2D), are now a widespread pandemic in the developed world. These...
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Sexual Dimorphism of Inputs to the Lateral Habenula in Mice
The lateral habenula (LHb), which is a critical neuroanatomical hub and a regulator of midbrain monoaminergic centers, is activated by events...
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Increased proliferation and neuronal fate in prairie vole brain progenitor cells cultured in vitro: effects by social exposure and sexual dimorphism
BackgroundThe prairie vole ( Microtus ochrogaster ) is a socially monogamous rodent that establishes an enduring pair bond after cohabitation, with...
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Sexual dimorphism in colorectal cancer: molecular mechanisms and treatment strategies
IntroductionSexual dimorphism significantly influences cancer incidence and prognosis. Notably, females exhibit a lower risk and favorable prognosis...
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Profiling the neuroimmune cascade in 3xTg-AD mice exposed to successive mild traumatic brain injuries
Repetitive mild traumatic brain injuries (rmTBI) sustained within a window of vulnerability can result in long term cognitive deficits, depression,...
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Identification of female-enriched and disease-associated microglia (FDAMic) contributes to sexual dimorphism in late-onset Alzheimer’s disease
BackgroundLate-onset Alzheimer’s disease (LOAD) is the most common form of dementia; it disproportionally affects women in terms of both incidence...
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A More Female-Characterized Resting-State Brain: Graph Similarity Analyses of Sex Influence on the Human Brain Intrinsic Functional Network
It remains unclear whether human species exhibits sexual dimorphism in brain activities, and how the dimorphisms associated with sex-characterized...
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Loss of Epitranscriptomic Modification N6-Methyladenosine (m6A) Reader YTHDF1 Exacerbates Ischemic Brain Injury in a Sexually Dimorphic Manner
N 6 -Methyladenosine (m 6 A) is a neuronal-enriched, reversible post-transcriptional modification that regulates RNA metabolism. The m 6 A-modified RNAs...
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Sex-Dimorphic Kidney-Brain Connectivity Map of Mice
The kidneys are essential organs that help maintain homeostasis, and their function is regulated by the neural system. Despite the anatomical...
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The Contribution of the Gut-Brain-Microbiota Axis to Brain Health Throughout the Lifespan
The gut-brain-microbiota axis (GBA) has recently been discussed as a role player in various disease states, including intestinal (such as...
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Integrated analysis of robust sex-biased gene signatures in human brain
BackgroundSexual dimorphism is highly prominent in mammals with many physiological and behavioral differences between male and female form of the...
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Male versus female inflammatory response after brain death model followed by ex vivo lung perfusion
BackgroundEx vivo lung perfusion (EVLP) is a useful tool for assessing lung grafts quality before transplantation. Studies indicate that donor sex is...
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Remembering the null hypothesis when searching for brain sex differences
Human brain sex differences have fascinated scholars for centuries and become a key focus of neuroscientists since the dawn of MRI. We recently...
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Sex Differentially Alters Secretion of Brain Extracellular Vesicles During Aging: A Potential Mechanism for Maintaining Brain Homeostasis
Extracellular vesicles (EVs) in the brain play a role in neuronal homeostasis by removing intracellular material and regulating cell-to-cell...
