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Generation of Bone Marrow Chimeras
Bone marrow chimeras are widely used in immunological studies, to dissect the contributions of hematopoietic and non-hematopoietic cells in immune...
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Bone marrow inflammation in haematological malignancies
Tissue inflammation is a hallmark of tumour microenvironments. In the bone marrow, tumour-associated inflammation impacts normal niches for...
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Hematopoietic Stem Cells and Their Bone Marrow Niches
Hematopoietic stem cells (HSCs) are maintained in the bone marrow microenvironment, also known as the niche, that regulates their proliferation,...
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Cellular plasticity of the bone marrow niche promotes hematopoietic stem cell regeneration
Hematopoietic stem cells (HSCs) regenerate after myeloablation, a procedure that adversely disrupts the bone marrow and drives leptin...
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Fibrosis and bone marrow: understanding causation and pathobiology
Bone marrow fibrosis represents an important structural change in the marrow that interferes with some of its normal functions. The aetiopathogenesis...
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Skull bone marrow channels as immune gateways to the central nervous system
Decades of research have characterized diverse immune cells surveilling the CNS. More recently, the discovery of osseous channels (so-called ‘skull...
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Lateralized response of skull bone marrow via osteopontin signaling in mice after ischemia reperfusion
Skull bone marrow is thought to be an immune tissue closely associated with the central nervous system (CNS). Recent studies have focused on the role...
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Determining hemodilution in diagnostic bone marrow aspirated samples in plasma cell disorders by next-generation flow cytometry: Proposal for a bone marrow quality index
Hemodilution of bone marrow (BM) aspirates is a limitation of multiparameter flow cytometry (MFC) in plasma cell disorders. There is a need for a...
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MECOM Deficiency: from Bone Marrow Failure to Impaired B-Cell Development
MECOM deficiency is a recently identified inborn error of immunity and inherited bone marrow failure syndrome caused by haploinsufficiency of the...
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Inhibition of caspase-8 cascade restrains the osteoclastogenic fate of bone marrow cells
Osteoclasts are multinucleated cells of hematopoietic origin, with a pivotal role in bone development and remodeling. Failure in osteoclast...
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Bone Marrow Failure and Immunodeficiency Associated with Human RAD50 Variants
PurposeThe MRE11-RAD50-NBN (MRN) complex plays a key role in recognizing and signaling DNA double-strand breaks. Pathogenic variants in NBN and MRE11 ...
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Predictive value of 18 F-FDG PET/CT versus bone marrow biopsy and aspiration in pediatric neuroblastoma
BackgroundNeuroblastoma (NB) is the most prevalent solid extracranial malignancy in children, often with bone marrow metastases (BMM) are present....
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Isolation of Murine Bone Marrow-Derived Neutrophils for Infection Modeling
West Nile virus (WNV) is a single-stranded-RNA flavivirus that can cause neurological illnesses. The ability of WNV to cause neurological illnesses...
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Palmitic acid-activated GPRs/KLF7/CCL2 pathway is involved in the crosstalk between bone marrow adipocytes and prostate cancer
BackgroundObesity-induced abnormal bone marrow microenvironment is one of the important risk element for bone metastasis in prostate cancer (PCa)....
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Adoptive Transfer and Bone Marrow Chimera Models to Analyze Treg Function and Differentiation
Cellular adoptive transferAdoptive transfer and mixed bone marrow chimeraBone marrow chimera are cornerstone experimental tools for immuno-biology....
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Purification of Bone Marrow Precursors to T Cells and ILCs
T cells and innate lymphoid cells (ILCs) share expression of many key transcription factors during development and at mature stage, resulting in...
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CDC-NET: a cell detection and confirmation network of bone marrow aspirate images for the aided diagnosis of AML
Standardized morphological evaluation in pathology is usually qualitative. Classifying and qualitatively analyzing the nucleated cells in the bone...
