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Ruthenium biochanin-A complex ameliorates lung carcinoma through the downregulation of the TGF-β/PPARγ/PI3K/TNF-α pathway in association with caspase-3-mediated apoptosis
Lung cancer is the most often reported cancer with a terrible prognosis worldwide. Flavonoid metal complexes have exhibited potential...
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Activity of isoflavone biochanin A in chronic experimental toxoplasmosis: impact on inflammation
Toxoplasma gondii is a worldwide prevalent parasite. The infection has been linked to variable inflammatory effects including neuroinflammation....
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Biochanin A Sensitizes Glioblastoma to Temozolomide by Inhibiting Autophagy
Resistance to temozolomide (TMZ) chemotherapy is the main reason for treatment failure in patients with glioblastoma (GBM). In the present study, we...
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The combination of Biochanin A and SB590885 potentiates the inhibition of tumour progression in hepatocellular carcinoma
BackgroundHepatocellular carcinoma (HCC) is the most aggressive and frequently diagnosed malignancy of the liver. Despite aggressive therapy, life...
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Biochanin A attenuates zymosan-induced arthritis in mice similarly to 17-β estradiol: an alternative to hormone replacement therapy?
Objective and designBiochanin A (BCA), a phytoestrogen, has various pharmacological properties. This study was conducted to compare BCA’s therapeutic...
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Biochanin A impedes STAT3 activation by upregulating p38δ MAPK phosphorylation in IL-6-stimulated macrophages
ObjectiveIL-6-induced STAT3 activation is associated with various chronic inflammatory diseases. In this study, we investigated the anti-STAT3...
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Mechanistic interplay of different mediators involved in mediating the anti-depressant effect of isoflavones
Depression is one of the most prevalent severe CNS disorders, which negatively affects social lives, the ability to work, and the health of people....
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Phytocompounds-Based Approaches to Combat Oxidative Stress in Cancer
Present chapter will have the focus on the phytocompounds-based approaches to combat oxidative stress in cancer. Oxidative stress plays important...
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Anti-influenza A virus activity of flavonoids in vitro: a structure–activity relationship
Secondary plant metabolites from food extracts, namely daidzein, quercetin, and luteolin, exhibit anti-influenza virus effects, with IC 50 values of...
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Flavonoid as possible therapeutic targets against COVID-19: a sco** review of in silico studies
ObjectivesThis sco** review aims to present flavonoid compounds’ promising effects and possible mechanisms of action on potential therapeutic...
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New isoflavone glucosides in yabumame (Amphicarpaea bracteata (L.) Fernald subsp. edgeworthii (Benth.) H.Ohashi var. japonica (Oliv.) H.Ohashi) and their effect on leukotriene B4 production in mast cells
AbstractYabumame ( Amphicarpaea bracteata (L.) Fernald subsp. edgeworthii (Benth.) H.Ohashi var. japonica (Oliv.) H.Ohashi) is a legume plant that...
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Phytocompounds-Based Approaches to Combat Oxidative Stress in Cancer
Present chapter will have the focus on the phytocompounds-based approaches to combat oxidative stress in cancer. Oxidative stress plays important...
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Recent Progress in the Pharmacology of Phytoestrogens: Emerging Neuromodulators for Treating Anxiety and Depression
Phytoestrogens are plant-derived non-steroidal xenoestrogens that possess an ability to bind with endogenous estrogen receptors and mildly mimic the...
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Isolation and evaluation of antiviral plant compounds against respiratory disease-causing viruses: a review
Influenza viruses are major concern worldwide due to their fast ability to spread, and causing the respiratory illness of varying severity. The rate...
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Flavonoids: A Promising Neuroprotectant and Its Salutary Effects on Age-Related Neurodegenerative Disorders
Neurodegenerative disorders have become one of the most serious threats to global civilization in recent years. According to present data and future...
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Role of polyphenolic compounds and their nanoformulations: a comprehensive review on cross-talk between chronic kidney and cardiovascular diseases
Chronic kidney disease (CKD) affects a huge portion of the world’s population and frequently leads to cardiovascular diseases (CVDs). It might be...
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Potential mechanisms of cancer prevention and treatment by sulforaphane, a natural small molecule compound of plant-derived
Despite recent advances in tumor diagnosis and treatment technologies, the number of cancer cases and deaths worldwide continues to increase yearly,...
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Beneficial effects of flavonoids on cardiovascular diseases by influencing NLRP3 inflammasome
Cardiovascular diseases (CVDs) are a leading cause of global mortality and have a high incidence rate worldwide. The function of inflammasomes in...
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Blood and Urinary Flavonoids
Flavonoids are a large and complex group of phenolic compounds present in plant origin foods that may promote health and prevent diseases in humans....
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Blood and Urinary Flavonoids
Flavonoids are a large and complex group of phenolic compounds present in plant origin foods that may promote health and prevent diseases in humans....