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Microglial Priming in Bilirubin-Induced Neurotoxicity
Neuroinflammation is a major contributor to bilirubin-induced neurotoxicity, which results in severe neurological deficits. Microglia are the primary...
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Bilirubin potentiates etomidate-induced sedation by enhancing GABA-induced currents after bile duct ligation
ObjectivesOur previous clinical trial showed that etomidate requirements to reach an appropriate level of anesthesia in patients with obstructive...
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Turn-Off Fluorometric Determination of Bilirubin Using Facile Synthesized Nitrogen-Doped Carbon Dots as a Fluorescent Probe
Bilirubin plays a significant role in human health management, particularly in the case of jaundice. Because of the need for the monitoring of...
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Preoperative serum bilirubin is an independent prognostic factor for curatively resected esophageal squamous cell carcinoma
PurposeThis study examines prognostic value of preoperative serum bilirubin, including unconjugated bilirubin (UCB), conjugated bilirubin (CB), and...
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Fluorescent Nitrogen-doped Carbon Dots-based Turn-off Sensor for Bilirubin
Bilirubin (BR), a heme protein produced from breakdown of haemoglobin is present in aged red blood cells; whose abnormal concentration is associated...
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Relationship between elevated bilirubin levels and enhanced warfarin effects during biliary obstruction
ObjectivesA marked prolongation of the prothrombin time-international normalized ratio (PT-INR) is frequently observed during biliary obstruction in...
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Inhibition of Microglial Activation Ameliorates Inflammation, Reduced Neurogenesis in the hippocampus, and Impaired Brain Function in a Rat Model of Bilirubin Encephalopathy
Hyperbilirubinemia is one of the most common occurrence in newborns and is toxic to the brain, resulting in neurological sequelae such as auditory...
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Bilirubin Induces A1-Like Reactivity of Astrocyte
Astrocytes play an important role in the pathogenesis of bilirubin neurotoxicity, and activated astrocytes might be potential mediators of...
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Protective and curative effects of unconjugated bilirubin on gene expression of LOX-1 and iNOS in the heart of rats receiving high-fat diet and low dose streptozotocin: a histomorphometric approach
BackgroundAtherosclerosis is a chronic inflammatory condition affecting the large arteries and is a major cause of cardiovascular diseases (CVDs)...
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Association of Total Bilirubin with Motor Signs in Early Parkinson’s Disease in LRRK2 Variant Carriers
Oxidative stress is considered a possible mechanism in Parkinson’s disease (PD) progression. Bilirubin has been recognized as a powerful antioxidant...
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Bilirubin ameliorates murine atherosclerosis through inhibiting cholesterol synthesis and resha** the immune system
Atherosclerosis is a chronic inflammatory disease caused mainly by lipid accumulation and excessive inflammatory immune response. Although the...
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Bilirubin represents a negative regulator of ILC2 in allergic airway inflammation
Group 2 innate lymphoid cells (ILC2s) play an important role in allergic airway inflammation. Despite recent advances in defining molecular...
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The association between bilirubin and hypertension among a Chinese ageing cohort: a prospective follow-up study
BackgroundHypertension is highly prevalent and associated with the elevated risks of cardiovascular diseases, dementia, and physical disabilities...
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Fluorescence Spectroscopic Studies to Evaluate Binding Interaction between Hoechst 33258 and Bilirubin
A detailed spectroscopic study (fluorescence, absorption, and lifetime) was conducted to gain insight into the nature of the binding interaction...
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UGT1A1 genetic variants are associated with increases in bilirubin levels in rheumatoid arthritis patients treated with sarilumab
Sarilumab is a human monoclonal antibody against interleukin (IL)-6Rα that has been approved for the treatment of adult patients with moderately to...
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Bilirubin: A Ligand of the PPARα Nuclear Receptor
Bilirubin is the product from red blood cell lysis, which releases heme that is reduced to biliverdin by heme oxygenases (HO). Later, the biliverdin...
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Machine learning-based normal tissue complication probability model for predicting albumin-bilirubin (ALBI) grade increase in hepatocellular carcinoma patients
Purpose:The aim of this study was to develop a normal tissue complication probability model using a machine learning approach (ML-based NTCP) to...
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Baseline Albumin-Bilirubin grade as a predictor of response and outcome of regorafenib therapy in patients with hepatocellular carcinoma: a systematic review and meta-analysis
BackgroundThe use of regorafenib in the treatment of hepatocellular carcinoma (HCC) is widespread. Albumin-Bilirubin (ALBI) has been shown to be a...
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Reactive Oxygen Species–Responsive Celastrol-Loaded Bilirubin Nanoparticles for the Treatment of Rheumatoid Arthritis
Celastrol (CLT) has shown anti-rheumatic activity against rheumatoid arthritis, while its poor water solubility and high organ toxicity restrict its...
