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TRPA1 participation in behavioral impairment induced by chronic corticosterone administration
RationaleMajor depressive disorder (MDD) is one of the most diagnosed mental disorders. Despite this, its pathophysiology remains poorly understood....
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Can Cerebellar Neurodevelopmental Disorders Affect Behavioral Disorders or Vice Versa?
Recent investigations have been focused on understanding the role of the cerebellum in non-motor behaviors and of the cerebellar dysfunction in...
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Treadmill Exercise Improves Behavioral and Neurobiological Alterations in Restraint-Stressed Rats
Stress is a state that is known to impact an organism’s physiological and psychological balance as well as the morphology and functionality of...
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Immune-to-Brain Signaling Effects on the Neural Substrate for Reward : Behavioral Models of Aversion , Anhedonia , and Despair
The role of immune-to-brain signaling in regulating mood and motivational states has received increasing interest, as clinical studies have uncovered...
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Unraveling psilocybin’s therapeutic potential: behavioral and neuroplasticity insights in Wistar-Kyoto and Wistar male rat models of treatment-resistant depression
RationaleOur study aimed to unravel the unknown mechanisms behind the exceptional efficacy of Psilocybin (PSI) in treating treatment-resistant...
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Neuroprotective Role of Selenium Nanoparticles Against Behavioral, Neurobiochemical and Histological Alterations in Rats Subjected to Chronic Restraint Stress
Chronic stress induces changes in the prefrontal cortex and hippocampus. Selenium nanoparticles (SeNPs) showed promising results in several...
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Behavioral and Psychological Changes in Alzheimer’s and Other Neurodegenerative Disorders
Cognitive, executive, and motor dysfunctions are widely regarded as the hallmarks of neurodegeneration. However, behavioral and mental disorders are...
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Neuroprotective effects of silymarin in 3-nitropropionic acid-induced neurotoxicity in male mice: improving behavioral deficits by attenuating oxidative stress and neuroinflammation
3-Nitropropionic acid (3-NP) is strongly believed to be an irreversible inhibitor of mitochondrial complex II, leading to neural damage. This study...
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Prenatal Stress Induces Long-Term Behavioral Sex-Dependent Changes in Rats Offspring: the Role of the HPA Axis and Epigenetics
Preclinical genetic studies have related stress early exposures with changes in gene regulatory mechanisms, including epigenetic alterations, such as...
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Hippocampal microRNA-26a-3p deficit contributes to neuroinflammation and behavioral disorders via p38 MAPK signaling pathway in rats
BackgroundNeuronal injury is considered a critical risk factor in the pathogenesis of most neurological and neuropsychiatric diseases. However, the...
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Behavioral and Psychological Changes in Alzheimer’s and Other Neurodegenerative Disorders
Cognitive, executive, and motor dysfunctions are widely regarded as the hallmarks of neurodegeneration. However, behavioral and mental disorders are...
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The role of mGluR5 on the therapeutic effects of ketamine in Wistar rats
RationaleKetamine produces dissociative, psychomimetic, anxiolytic, antidepressant, and anesthetic effects in a dose dependent manner. It has a...
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Behavioral Effects of 4-CMC and 4-MeO-PVP in DBA/2J Mice After Acute and Intermittent Administration and Following Withdrawal from Intermittent 14-Day Treatment
Synthetic cathinones appeared on the market in the 2000s as new psychoactive substances and gained significant prevalence among drug abusers....
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Investigation of non-invasive focused ultrasound efficacy on depressive-like behavior in hemiparkinsonian rats
Depression is a common non-motor symptom in Parkinson’s disease (PD) that includes anhedonia and impacts quality of life but is not effectively...
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Th17 cells sense microbiome to promote depressive-like behaviors
BackgroundMicrobiome alterations have been associated with depression, and fecal transfer of depressed patients’ microbiomes is sufficient to enhance...
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Effect of M2 Macrophage-Derived Soluble Factors on Behavioral Patterns and Cytokine Production in Various Brain Structures in Depression-Like Mice
We studied the effect of soluble factors derived from human macrophages polarized to M2 phenotype under conditions of serum deprivation (M2-SF) on...
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Long term high fat diet induces metabolic disorders and aggravates behavioral disorders and cognitive deficits in MAPT P301L transgenic mice
Most Alzheimer disease (AD) patients present as sporadic late onset AD, with metabolic factors playing an important role in the occurrence and...
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Sigma-1 receptor activation mediates the sustained antidepressant effect of ketamine in mice via increasing BDNF levels
Sigma-1 receptor (S1R) is a unique multi-tasking chaperone protein in the endoplasmic reticulum. Since S1R agonists exhibit potent...
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Taurine, an essential β-amino acid insulates against ketamine-induced experimental psychosis by enhancement of cholinergic neurotransmission, inhibition of oxidative/nitrergic imbalances, and suppression of COX-2/iNOS immunoreactions in mice
Cholinergic, oxidative, nitrergic alterations, and neuroinflammation are some key neuropathological features common in schizophrenia disease. They...
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Behavioral Paradigms for Assessing Cognitive Functions in the Chronic Social Defeat Stress Model of Depression
Depression is a debilitating mental disorder that affects hundreds of millions of individuals worldwide. Also referred to as major depressive...