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Effects of social housing conditions on ethanol-induced behavioral sensitization in Swiss mice
RationaleIn previous animal model studies, it was shown that drug sensitization is dependent upon physical environmental conditions. However, the...
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The neuroimmunology of social-stress-induced sensitization
Myriad clinical findings provide links between chronic stressors, inflammation, and mood disorders. Furthermore, traumatic or chronic exposure to...
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Effect of exercise duration on toluene-induced locomotor sensitization in mice: a focus on the Renin Angiotensin System
RationaleExercise attenuates addictive behavior; however, little is known about the contribution of exercise duration to this positive effect. The...
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Cocaine-induced sensitization and glutamate plasticity in the nucleus accumbens core: effects of sex
BackgroundThe development and persistence of addiction is mediated in part by drug-induced alterations in nucleus accumbens (NAc) function. AMPA-type...
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The cognitive and behavioral effects of D-amphetamine and nicotine sensitization in adult zebrafish
BackgroundZebrafish are growing in use as a model for understanding drug dependence and addiction. Sensitization paradigms have been a useful tool in...
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Intrathecal Fumagillin Alleviates Chronic Neuropathy-Induced Nociceptive Sensitization and Modulates Spinal Astrocyte-Neuronal Glycolytic and Angiogenic Proteins
Nociceptive sensitization is accompanied by the upregulation of glycolysis in the central nervous system in neuropathic pain. Growing evidence has...
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The role of CYP2D in rat brain in methamphetamine-induced striatal dopamine and serotonin release and behavioral sensitization
RationaleCytochrome P450 2D (CYP2D) enzymes metabolize many addictive drugs, including methamphetamine. Variable CYP2D metabolism in the brain may...
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Behavioral sensitization induced by methamphetamine causes differential alterations in gene expression and histone acetylation of the prefrontal cortex in rats
BackgroundMethamphetamine (METH) is one of the most widely abused illicit substances worldwide; unfortunately, its addiction mechanism remains...
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TLR2 Mediates Microglial Activation and Contributes to Central Sensitization in a Recurrent Nitroglycerin-induced Chronic Migraine Model
Central sensitization is an important pathophysiological mechanism underlying chronic migraine (CM). Previous studies have shown that microglial...
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P2X7 and P2Y1 receptors in DRG mediate electroacupuncture to inhibit peripheral sensitization in rats with IBS visceral pain
Although multiple purinergic receptors mediate the analgesic effects of acupuncture, it remains unclear whether there is mutual interaction between...
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Potentiated Response of ERK/MAPK Signaling is Associated with Prolonged Withdrawal from Cocaine Behavioral Sensitization
Among the neuroadaptations underlying the expression of cocaine-induced behaviors are modifications in glutamate-mediated signaling and synaptic...
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Suberoylanilide Hydroxamic Acid Ameliorates Pain Sensitization in Central Neuropathic Pain After Spinal Cord Injury via the HDAC5/NEDD4/SCN9A Axis
Pain sensitization in spinal cord injury (SCI)-induced central neuropathic pain has been a research target. Additionally, suberoylanilide hydroxamic...
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Effects of repeated treatment with the 5-HT1A and 5-HT1B agonists (R)-( +)-8-hydroxy-DPAT and CP-94253 on the locomotor activity and axillary temperatures of preweanling rats: evidence of tolerance and behavioral sensitization
RationaleDrugs that stimulate 5-HT 1A/1B receptors produce both tolerance and behavioral sensitization in adult rats and mice, yet it is unknown...
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The influence of sex and reproductive cycle on cocaine-induced behavioral and neurobiological alterations: a review
This systematic review (SR) was aimed at answering two questions: (1) how sex and ovarian hormones alter behavior associated with cocaine use; (2)...
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Repeated closed-head mild traumatic brain injury-induced inflammation is associated with nociceptive sensitization
BackgroundIndividuals who have experienced mild traumatic brain injuries (mTBIs) suffer from several comorbidities, including chronic pain. Despite...
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Glutamate inputs from the laterodorsal tegmental nucleus to the ventral tegmental area are essential for the induction of cocaine sensitization in male mice
RationaleDrug-induced potentiation of ventral tegmental area (VTA) glutamate signaling contributes critically to the induction of sensitization - an...
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Behavioral Tests for Associative Learning in Caenorhabditis elegans
Learning is critical for survival as it provides the capacity to adapt to a changing environment. At the molecular and cellular level, learning leads...
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Chemogenetic modulation reveals distinct roles of the subthalamic nucleus and its afferents in the regulation of locomotor sensitization to amphetamine in rats
The subthalamic nucleus (STN) is a key node in cortico-basal-ganglia thalamic circuits, guiding behavioral output through its position as an...
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mTOR regulates cocaine-induced behavioural sensitization through the SynDIG1–GluA2 interaction in the nucleus accumbens
Behavioral sensitization is a progressive increase in locomotor or stereotypic behaviours in response to drugs. It is believed to contribute to the...
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Moderate intensity aerobic training reduces the signs of peripheral sensitization in a mouse model of type 2 diabetes mellitus
Type 2 diabetes mellitus (T2DM) is a global health problem for many reasons including the comorbidities, such as diabetic neuropathy (DPN), which is...
