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Autoimmune Diseases
For the phenomenon of autoimmune diseases, partial loss of immunological tolerance is key. The main disease is multiple sclerosis. It is still not...
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Primary Autoimmune Cerebellar Ataxia (PACA)
Immune-mediated ataxias are likely to account for a large number of progressive ataxias. Advances in the field of immune-mediated ataxias meant that...
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Immunoinformatics for the Diagnosis and Monitoring of Autoimmune Diseases
A complicated and diverse set of illnesses known as autoimmune diseases occur when the immune system attacks healthy cells and tissues, causing...
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Chimeric antigen receptor T cell therapy for autoimmune disease
Infusion of T cells engineered to express chimeric antigen receptors (CARs) that target B cells has proven to be a successful treatment for B cell...
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Lymphocyte-Directed Immunomodulation Remits Thymoma-Associated Autoimmune Pneumonitis
BackgroundThymoma presents with several autoimmune manifestations and is associated with secondary autoimmune regulator (AIRE) deficiency....
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Contributions of Synthetic Chemicals to Autoimmune Disease Development and Occurrence
Purpose of ReviewExposure to many synthetic chemicals has been linked to a variety of adverse human health effects, including autoimmune diseases. In...
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Learning the Autoimmune Pathogenesis Through the Study of Aire
One of the difficulties in studying the pathogenesis of autoimmune diseases is that the disease is multifactorial involving sex, age, MHC,...
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Exploring the relationship between infectious agents and autoimmune diseases: a review
The relationship between infectious agents and autoimmune diseases is a complex issue. In recent years, increasing clinical cases have indicated that...
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Autoimmune diseases: targets, biology, and drug discovery
Autoimmune diseases (AIDs) arise from a breakdown in immunological self-tolerance, wherein the adaptive immune system mistakenly attacks healthy...
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Neoself Antigens Presented on MHC Class II Molecules in Autoimmune Diseases
Major histocompatibility complex (MHC) class II molecules play a crucial role in immunity by presenting peptide antigens to helper T cells. Immune...
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Genetic map** across autoimmune diseases reveals shared associations and mechanisms
Autoimmune and inflammatory diseases are polygenic disorders of the immune system. Many genomic loci harbor risk alleles for several diseases, but...
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Pertussis toxin-induced inhibition of Wnt/β-catenin signaling in dendritic cells promotes an autoimmune response in experimental autoimmune uveitis
BackgroundPrevious reports have indicated that disrupting the Wnt/β-catenin pathway in dendritic cells (DCs) may affect the progression of autoimmune...
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Targeting PGLYRP1 promotes antitumor immunity while inhibiting autoimmune neuroinflammation
Co-inhibitory and checkpoint molecules suppress T cell function in the tumor microenvironment, thereby rendering T cells dysfunctional. Although...
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HMGB1 and Toll-like receptors: potential therapeutic targets in autoimmune diseases
HMGB1, a nucleoprotein, is expressed in almost all eukaryotic cells. During cell activation and cell death, HMGB1 can function as an alarm protein...
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Autoimmune conditions and gastric cancer risk in a population-based study in the United Kingdom
BackgroundAlthough overall incidence of gastric cancer is decreasing, incidence has been increasing among young people in some Western countries....
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Consensus Paper: Latent Autoimmune Cerebellar Ataxia (LACA)
Immune-mediated cerebellar ataxias (IMCAs) have diverse etiologies. Patients with IMCAs develop cerebellar symptoms, characterized mainly by gait...
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Autoimmune-mediated astrocytopathy
Recently accumulating evidence identified the disease entity where astrocytes residing within the central nervous system (CNS) are the target of...
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Kinesin-5 inhibition improves neural regeneration in experimental autoimmune neuritis
BackgroundAutoimmune neuropathies can result in long-term disability and incomplete recovery, despite adequate first-line therapy. Kinesin-5...
