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A Review on Caspases: Key Regulators of Biological Activities and Apoptosis
Caspases are proteolytic enzymes that belong to the cysteine protease family and play a crucial role in homeostasis and programmed cell death....
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Caspases in Alzheimer’s Disease: Mechanism of Activation, Role, and Potential Treatment
With the aging of the population, treatment of conditions emerging in old age, such as neurodegenerative disorders, has become a major medical...
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Independent role of caspases and Bik in augmenting influenza A virus replication in airway epithelial cells and mice
Caspases and poly (ADP-ribose) polymerase 1 (PARP1) have been shown to promote influenza A virus (IAV) replication. However, the relative importance...
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Apoptotic proteins with non-apoptotic activity: expression and function in cancer
Apoptosis is a process of programmed cell death in which a cell commits suicide while maintaining the integrity and architecture of the tissue as a...
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Comparison of immunotherapy mediated by apoptotic bodies, microvesicles and exosomes: apoptotic bodies’ unique anti-inflammatory potential
Immunotherapy, including immunostimulation and immunosuppression, has seen significant development in the last 10 years. Immunostimulation has been...
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Magnetospirillum magneticum triggers apoptotic pathways in human breast cancer cells
The use of bacteria in cancer immunotherapy has the potential to bypass many shortcomings of conventional treatments. The ability of anaerobic...
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Partial changes in apoptotic pathways in hippocampus and hypothalamus of Cc2d1a heterozygous
Alterations in the apoptosis pathway have been linked to changes in serotonin levels seen in autistic patients. Cc2d1a is a repressor of the HTR1A ...
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The therapeutic potential of targeting regulated non-apoptotic cell death
Cell death is critical for the development and homeostasis of almost all multicellular organisms. Moreover, its dysregulation leads to diverse...
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Do Marine Polysaccharides Carrageenans Modulate Non-apoptotic Regulated Cell Deaths ? (a Review)
Purpose of ReviewA growing number of studies indicate that a network of regulated cell death (RCD) pathways plays a vital role in tumorigenesis...
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Inflammasome Activation Mediates Apoptotic and Pyroptotic Death in Astrocytes Under Ischemic Conditions
Inflammation is a hallmark mechanism of ischemic stroke-induced brain injury. Recent studies have shown that an intracellular multimeric protein...
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Apoptotic contraction drives target cell release by cytotoxic T cells
Cytotoxic T lymphocytes (CTLs) fight intracellular pathogens and cancer by identifying and destroying infected or transformed target cells
1 . To kill,...
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Cell Death-NO-Today: Effect of NO and RNS on Non-apoptotic Regulated Cell Death
Nitric oxide (NO), generated either enzymatically or non-enzymatically plays a significant role in cellular physiology. At low concentration, NO acts...
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Apoptotic Pathways and Alzheimer’s Disease: Probing Therapeutic Potential
Apoptosis is an intrinsic biochemical, cellular process that regulates cell death and is crucial for cell survival, cellular homeostasis, and...
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Pro-apoptotic Effects of Dietary Flavonoids In Oxidative Stress-Induced Cancer
Flavonoids are bioactives that are seen abundantly in various parts of plants, especially in fruits and vegetables. Flavonoids are classified into...
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Pro-apoptotic Effects of Dietary Flavonoids in Oxidative Stress-Induced Cancer
Flavonoids are bioactives that are seen abundantly in various parts of plants, especially in fruits and vegetables. Flavonoids are classified into...
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Single-Cell Profiling of the Intrinsic Apoptotic Pathway by Mass Cytometry (CyTOF)
Mass cytometry time-of-flight (CyTOF) is a technology for the study of complex biological processes at the single-cell level. The technology enables...
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Implication of extrinsic and intrinsic apoptotic pathways in the targeted therapy of hepatocellular carcinoma using aptamer-labeled viramidine nanoparticles
Hepatocellular carcinoma (HCC) is a global health problem with regional differences in epidemiological statistics. Co-assembling the drug...
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Non-apoptotic Cell Death Control of Neutrophil Extracellular Trap Formation
Neutrophil extracellular traps (NETs) are networks of chromatin and microbicidal proteins released by neutrophils in response to infection and tissue...
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Apoptosis in Alzheimer’s disease: insight into the signaling pathways and therapeutic avenues
Alzheimer’s disease (AD) is characterized by the accumulation of hyperphosphorylated tau and amyloid-β (Aβ) protein resulting in synaptic loss and...
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Potential antiproliferative and apoptotic effects of pilocarpine combined with TNF alpha in chronic myeloid leukemia cells
Pilocarpine is a selective M 1 /M 3 agonist of muscarinic acetylcholine receptor subtypes. Muscarinic acetylcholine receptors are G protein-coupled...
