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Pro-apoptotic Effects of Dietary Flavonoids In Oxidative Stress-Induced Cancer

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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

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Abstract

Flavonoids are bioactives that are seen abundantly in various parts of plants, especially in fruits and vegetables. Flavonoids are classified into different subclasses, including anthocyanins, flavanols, chalcones, flavanones, flavones, and isoflavones. Many dietary flavonoids exhibit health-promoting effects, mainly disease preventive actions such as antioxidant, antimicrobial, cardioprotective, hepatoprotective, neuroprotective, antidiabetic, anti-inflammatory, antiproliferative, and anti-cancer. Dietary flavonoids typically help to reduce cellular oxidative stress and modulate dysregulated signaling pathways and thereby gene expression. Oxidative stress regulation is an essential factor in cancer treatment. Normal and cancerous cells mainly differ in their redox status. In cancer cells, there are increased levels of reactive oxygen species; hence, several anti-cancer therapies largely focus on modulating these reactive oxygen species levels. Recent studies suggest that small molecules with bioactive properties support to reduce the side effects of anti-cancer drugs. This chapter will briefly discuss the pro-apoptotic effects of some of the major dietary flavonoids such as quercetin, morin, EGCG, genistein, daidzein, apigenin, luteolin, and myricetin in oxidative stress-induced cancers.

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Authors and Affiliations

  1. Department of Biochemistry, CSIR-Central Food Technological Research Institute, Mysore, Karnataka, India

    Vani Vijay, Nivya Vijayan, V. P. Venkatiesh, Baskaran Vallikannan & Madan Kumar Perumal

  2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India

    Madan Kumar Perumal

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  1. Vani Vijay
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  2. Nivya Vijayan
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  3. V. P. Venkatiesh
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  4. Baskaran Vallikannan
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  5. Madan Kumar Perumal
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Correspondence to Madan Kumar Perumal .

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Editors and Affiliations

  1. Dept Biochem & Biophysics, C-Block, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

Section Editor information

  1. Chair and Department of Toxicology, Jagiellonian University Collegium Medicum, Kraków, Poland

    Maria Walczak

  2. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Tapati Chakraborti

  3. Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK

    Pulak Kar

  4. University of Burdwan, Bardhaman, West Bengal, India

    Somasri Dam

  5. Institute of Veterinary Physiology, University of Zurich, Zurich, Switzerland

    Kuntal Dey

  6. Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, USA

    Muthusamy Kunnimalaiyaan

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Vijay, V., Vijayan, N., Venkatiesh, V.P., Vallikannan, B., Perumal, M.K. (2022). Pro-apoptotic Effects of Dietary Flavonoids In Oxidative Stress-Induced Cancer. In: Chakraborti, S. (eds) Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore. https://doi.org/10.1007/978-981-16-1247-3_151-1

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  • DOI: https://doi.org/10.1007/978-981-16-1247-3_151-1

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