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Avoidance of cutaneous adverse drug reactions induced by antiepileptic drugs based on pharmacogenomics
Pharmacogenomics (PGx) is a research area aimed at identifying genetic factors that are associated with drug responses, including drug efficacy,...
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Screening Methods for the Evaluation of Antiepileptic Drugs
Seizure is sudden disorganized uncontrolled electrical activity in the brain, leading to alteration of behaviors, movement, or level of...
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COVID-19 and antiepileptic drugs: an approach to guide practices when nirmatrelvir/ritonavir is co-prescribed
Management and dose adjustment are a major concern for clinicians in the absence of specific clinical outcome data for patients on antiepileptic...
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SCN8A epileptic encephalopathy mutations display a gain-of-function phenotype and divergent sensitivity to antiepileptic drugs
De novo missense mutations in SCN8A gene encoding voltage-gated sodium channel Na V 1.6 are linked to a severe form of early infantile epileptic...
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Effects of New-Generation Antiepileptic Drug Prophylaxis on Delayed Neurovascular Events After Aneurysmal Subarachnoid Hemorrhage
Neuroelectric disruptions such as seizures and cortical spreading depolarization may contribute to the development of delayed cerebral ischemia (DCI)...
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Design, synthesis, in vivo and in silico evaluation of novel benzothiazole-hydrazone derivatives as new antiepileptic agents
In humans, epilepsy becomes a serious health problem due to scarcity of effective medications against it. Most of the available anti-epileptic drugs...
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Thermoresponsive Gel-loaded Oxcarbazepine Nanosystems for Nose- To-Brain Delivery: Enhanced Antiepileptic Activity in Rats
BackgroundOxcarbazepine (OXC) is a frequently prescribed antiepileptic drug for managing focal and generalized seizures. Its therapeutic benefits are...
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Efficacy of Fenfluramine and Norfenfluramine Enantiomers and Various Antiepileptic Drugs in a Zebrafish Model of Dravet Syndrome
Dravet syndrome (DS) is a rare genetic encephalopathy that is characterized by severe seizures and highly resistant to commonly used antiepileptic...
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Feasibility of Using Oral Fluid for Therapeutic Drug Monitoring of Antiepileptic Drugs
Therapeutic drug monitoring (TDM) of antiepileptic drugs (AED) using blood is well established but limited by its invasiveness, accessibility, cost,...
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Epilepsy and COVID-19: Management of Patients and Optimization of Antiepileptic Treatment in the Pandemic
There are as yet no data pointing to any increase in the incidence of the novel coronavirus infection (COVID-19) or a more severe course of illness...
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Moderate alcohol consumption during pregnancy increases potency of two different drugs (the antifungal fluconazole and the antiepileptic valproate) in inducing craniofacial defects: prediction by the in vitro rat whole embryo culture
AbstractThe prenatal exposure to ethanol (Eth), fluconazole (FLUCO) and sodium valproate (VPA) is related to effects on development, producing...
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The Aqueous Lyophilisate of Alchemilla Kiwuensis Engl. (Rosaceae) Displays Antiepileptogenic and Antiepileptic Effects on PTZ-induced Kindling in rats: Evidence of Modulation of Glutamatergic and GABAergic Pathways Coupled to Antioxidant Properties
Alchemilla kiwuensis Engl. (Rosaceae) (A. kiwuensis) is an herbaceous plant traditionally used by Cameroonians to treat epilepsy and other central...
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Spectrum of cutaneous adverse reactions to aromatic antiepileptic drugs and human leukocyte antigen genotypes in Thai patients and meta-analysis
Aromatic antiepileptic drugs (AEDs)-induced cutaneous adverse drug reactions (cADRs) add up to the limited use of the AEDs in the treatment and...
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Repurposing an Antiepileptic Drug for the Treatment of Glioblastoma
PurposeGlioblastoma multiforme (GBM) is a grade IV, highly proliferative, and malignant form of brain tumor with a 5-year survival rate at ~ 5%....
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Acyl-CoA thioesters as chemically-reactive intermediates of carboxylic acid-containing drugs
Several carboxylic acid-containing drugs have been withdrawn from clinical use due to adverse drug reactions including idiosyncratic hepatotoxicity...
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Unraveling the Mechanisms of Clinical Drugs-Induced Neural Tube Defects Based on Network Pharmacology and Molecular Docking Analysis
Chemotherapeutic agents such as methotrexate (MTX), raltitrexed (RTX), 5-fluorouracil (5-FU), hydroxyurea (HU), and retinoic acid (RA), and valproic...
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Synthesis and clinical application of new drugs approved by FDA in 2022
The pharmaceutical industry had a glorious year in 2022, with a total of 37 new drugs including 20 new chemical entities (NCEs) and 17 new biological...
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Melt Crystallization of Celecoxib-Carbamazepine Cocrystals with the Synchronized Release of Drugs
PurposeThe fixed-dose combination drug products have been increasingly used to treat some complex diseases. A cocrystal containing two therapeutic...
