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Avoidance of cutaneous adverse drug reactions induced by antiepileptic drugs based on pharmacogenomics
Pharmacogenomics (PGx) is a research area aimed at identifying genetic factors that are associated with drug responses, including drug efficacy,...
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Effects of New-Generation Antiepileptic Drug Prophylaxis on Delayed Neurovascular Events After Aneurysmal Subarachnoid Hemorrhage
Neuroelectric disruptions such as seizures and cortical spreading depolarization may contribute to the development of delayed cerebral ischemia (DCI)...
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Thermoresponsive Gel-loaded Oxcarbazepine Nanosystems for Nose- To-Brain Delivery: Enhanced Antiepileptic Activity in Rats
BackgroundOxcarbazepine (OXC) is a frequently prescribed antiepileptic drug for managing focal and generalized seizures. Its therapeutic benefits are...
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Repurposing an Antiepileptic Drug for the Treatment of Glioblastoma
PurposeGlioblastoma multiforme (GBM) is a grade IV, highly proliferative, and malignant form of brain tumor with a 5-year survival rate at ~ 5%....
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The use of therapeutic drug monitoring to highlight an over-looked drug-drug interaction leading to imatinib treatment failure
BackgroundChronic oral anticancer therapies, are increasingly prescribed and present new challenges including the enhanced risk of overlooked...
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Drug-Drug and Food-Drug Interactions of Pharmacokinetic Nature
The most relevant pharmacokinetic mechanisms of drug-drug (DD) and food-drug (FD) interactions are summarized from a perspective that will allow the...
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Screening Methods for the Evaluation of Antiepileptic Drugs
Seizure is sudden disorganized uncontrolled electrical activity in the brain, leading to alteration of behaviors, movement, or level of...
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Nanotechnological Drug Delivery Strategies in Epilepsy
Epilepsy is a chronic disease of the central nervous system characterized by an electrical imbalance in neurons. It is the second most prevalent...
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Design, synthesis, in vivo and in silico evaluation of novel benzothiazole-hydrazone derivatives as new antiepileptic agents
In humans, epilepsy becomes a serious health problem due to scarcity of effective medications against it. Most of the available anti-epileptic drugs...
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Cellular and Molecular Mechanisms of Neuroinflammation in Drug-Resistant Epilepsy
Drug-resistant epilepsy (DRE) is characterized by the persistence of epileptic seizures despite the administration of antiepileptic treatments. The...
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COVID-19 and antiepileptic drugs: an approach to guide practices when nirmatrelvir/ritonavir is co-prescribed
Management and dose adjustment are a major concern for clinicians in the absence of specific clinical outcome data for patients on antiepileptic...
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Feasibility of Using Oral Fluid for Therapeutic Drug Monitoring of Antiepileptic Drugs
Therapeutic drug monitoring (TDM) of antiepileptic drugs (AED) using blood is well established but limited by its invasiveness, accessibility, cost,...
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The Aqueous Lyophilisate of Alchemilla Kiwuensis Engl. (Rosaceae) Displays Antiepileptogenic and Antiepileptic Effects on PTZ-induced Kindling in rats: Evidence of Modulation of Glutamatergic and GABAergic Pathways Coupled to Antioxidant Properties
Alchemilla kiwuensis Engl. (Rosaceae) (A. kiwuensis) is an herbaceous plant traditionally used by Cameroonians to treat epilepsy and other central...
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Drug-Induced Tremors
Drug-induced tremors are common in clinical practice, but often underrecognized or misdiagnosed. There are a myriad of drugs that can cause or...
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Cenobamate: Neuroprotective Potential of a New Antiepileptic Drug
Central nervous system (CNS) injuries annually afflict approximately 2.7 million people in United States only, inflicting costs of nearly 100 billion...
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Development and Use of an Ex-Vivo In-Vivo Correlation to Predict Antiepileptic Drug Clearance in Patients Undergoing Continuous Renal Replacement Therapy
ObjectivesResults from previous ex-vivo continuous renal replacement therapy (CRRT) models have successfully demonstrated similar extraction...
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Contribution of the Antiepileptic Drug Administration Regime to Avoid the Development and/or Establishment of Pharmacoresistant Epilepsy
Although drug-resistant epilepsy has been explained by different mechanisms, the most accepted one involves overexpression of efflux transporters at...
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Characterization of drug-induced liver injury associated with drug reaction with eosinophilia and systemic symptoms in two prospective DILI registries
Idiosyncratic drug-induced liver injury (DILI) associated with drug reactions with eosinophilia and systemic symptoms (DRESS) is poorly characterized...
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SCN8A epileptic encephalopathy mutations display a gain-of-function phenotype and divergent sensitivity to antiepileptic drugs
De novo missense mutations in SCN8A gene encoding voltage-gated sodium channel Na V 1.6 are linked to a severe form of early infantile epileptic...
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