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Divergent Approaches Toward Drug Discovery and Development
The drug discovery process aims to identify new chemical entities (NCEs) that are therapeutically beneficial for the management and/or cure of...
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Perillyl alcohol decreases the frequency and severity of convulsive-like behavior in the adult zebrafish model of acute seizures
This research aimed to assess the effect of perillyl alcohol (PA) on convulsive behavior in vivo using adult zebrafish ( Danio rerio , both sexes). The...
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Target Analysis of Designer Benzodiazepines in Blood and Urine
In recent years, the market for new psychoactive substances (NPS) has exploded, with a continuous stream of new compounds being introduced on a...
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C. elegans as a Potential Model for Acute Seizure-Like Activity
Conventional rodent models have provided invaluable tools for the discovery and characterization of antiepileptic drugs (AEDs). Nevertheless, around...
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Screening of Synthetic Isoxazolone Derivative Role in Alzheimer’s Disease: Computational and Pharmacological Approach
Alzheimer's disease (AD) is age-dependent neurological disorder with progressive loss of cognition and memory. This multifactorial disease is...
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Repurposing of Drug: Utility of Animal Models
Drug repurposing is an up-and-coming concept in the world of medicine. It is an efficient way to use already existing drug formulations in the...
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Potential of the zebrafish (Danio rerio) embryo test to discriminate between chemicals of similar molecular structure—a study with valproic acid and 14 of its analogues
Valproic acid is a frequently used antiepileptic drug and known pediatric hepatotoxic agent. In search of pharmaceuticals with increased...
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P/Q type (Cav2.1) Calcium Channel Blocker ω-Agatoxin IVA Alters Cleaved Caspase-3 and BDNF Expressions in the Rat Brain and Suppresses Seizure Activity
High-voltage-gated calcium channels have pivot role in the cellular and molecular mechanisms of various neurological disorders, including epilepsy....
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The CanPain SCI clinical practice guidelines for rehabilitation management of neuropathic pain after spinal cord injury: 2021 update
Study designClinical practice guidelines.
ObjectivesThe objective was to update the 2016 version of the Canadian clinical practice guidelines for...
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Trawling the Genome: Drug Target Identification in the Postgenomic Era
Drug discovery is the mainstay of the pharmaceutical industry. Despite the advent of technologies that enable a deep understanding of diseases at the...
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Fixed Dose Combination Tablets of Aripiprazole and Divalproex Sodium: a Pilot Pharmacokinetic Study in Human Volunteers
A combination product of aripiprazole (antipsychotic) and divalproex sodium (mood stabilizer) was recently developed to establish their tolerability...
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Transcranial brain parenchyma sonography in patients with juvenile myoclonic epilepsy
IntroductionThere are rising evidences that subcortical structures, including the basal ganglia, are affected in patients with epilepsy. These...
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Repurposing of Drug: Utility of Animal Models
Drug repurposing is an up-and-coming concept in the world of medicine. It is an efficient way to use already existing drug formulations in the...
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Gamma glutamyl transferases in association with cardiovascular risk scores in non-diabetic hypertensive Cameroonians: preliminary data from HYRICCA study
ObjectiveThe usefulness of gamma glutamyl transferase (GGT) as biomarker of cardiovascular risk (CVR) remains unexplored in sub-Saharan Africans. To...
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Next generation sequencing in neonatology: what does it mean for the next generation?
Rapid whole genome sequencing (WGS) and whole exome sequencing (WES), sometimes referred to as “next generation sequencing” (NGS) are now recommended...
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Phenotypic drug discovery: recent successes, lessons learned and new directions
Many drugs, or their antecedents, were discovered through observation of their effects on normal or disease physiology. For the past generation, this...
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Procedures for Electrical and Chemical Kindling Models in Rats and Mice
Since the first description of the kindling phenomenon, kindling paradigms have become frequently used chronic models in epilepsy research. The...
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Detection of Deregulated miRNAs in Childhood Epileptic Encephalopathies
The term “epileptic encephalopathy” is used to describe a possible relationship between epilepsy and developmental delay. The pathogenesis of...
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Design & synthesis of hybrid pharmacophore of β-lactam, 1,8-naphthyridine, and secondary amines; Discover their in vitro antimicrobial, anticancer properties & DFT and ADMET prediction studies
An efficient synthetic strategy was developed for the synthesis of hybrid pharmacophores; encompass the merging of β -lactams, 1,8-naphthyridine and...
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Association of TPH1 and TPH2 Gene Polymorphisms with the Risk of Develo** Psychoneurological Disorders
The question of the involvement of impairments to the metabolism of melatonin and its precursors (tryptophan and serotonin) in the development of...