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High resolution HLA-DRB1 analysis and shared molecular amino acid signature of DRβ1 molecules in Occult hepatitis B infection
AimTo investigate the association of human leukocyte antigen (HLA)-DRB1 alleles and the variations of polymorphic amino acid changes in DRβ1 chain in...
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Identification of Non-excitatory Amino Acids and Transporters Mediating the Irreversible Synaptic Silencing After Hypoxia
The contribution of excitatory amino acids (AA) to ischemic brain injury has been widely described. In addition, we reported that a mixture of...
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Symmetric inheritance of parental histones governs epigenome maintenance and embryonic stem cell identity
Modified parental histones are segregated symmetrically to daughter DNA strands during replication and can be inherited through mitosis. How this may...
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The role of transcription factors in sha** regulatory T cell identity
Forkhead box protein 3-expressing (FOXP3 + ) regulatory T cells (T reg cells) suppress conventional T cells and are essential for immunological...
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Hit-to-lead optimization of amino-carboxamide benzothiazoles as LSD1 inhibitors
The lysine-specific demethylase enzyme (LSD1) is a potential therapeutic target in cancer, which has a significant role in oncogenic processes such...
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Targeting Acid-Sensing Ion Channels in Disease
Acidosis is a central feature of many pathological conditions, and while the activity of many ion channels is suppressed under acidic conditions,...
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Identifying novel amino acid substitutions of hemagglutinin involved in virulence enhancement in H7N9 virus strains
BackgroundTo identify site-specific features of amino acid substitutions that confer enhanced H7N9 virulence in humans, we independently generated...
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Effects of Bullfrog Sialic Acid–Binding Lectin in Cancer Cells
A cancer cell agglutinin isolated from bullfrog (Rana catesbeiana) eggs was named R. catesbeiana sialic acid–binding lectin (cSBL), because its...
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Complete genome sequence of a new putative member of the genus Pelarspovirus that infects Quercus aliena Blume in South Korea
The complete nucleotide sequence of a newly discovered virus infecting Quercus aliena Blume, tentatively named “quercus leafroll virus” (QLRV), was...
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Sequencing and biological characterization of historical cynosurus mottle virus isolates from Germany
We report sequencing of four historical cynosurus mottle virus (CnMoV) isolates, originating from different hosts and locations. The CnMoV genome,...
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Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development
The mammalian telencephalon contains distinct GABAergic projection neuron and interneuron types, originating in the germinal zone of the embryonic...
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The effect of single amino acid substitution at position 220 in the hemagglutinin glycoprotein on avian influenza H7N9 candidate vaccine virus
Influenza vaccines represent the most effective preventive strategy to control influenza virus infections; however, adaptive mutations frequently...
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The percentages of SARS-CoV-2 protein similarity and identity with SARS-CoV and BatCoV RaTG13 proteins can be used as indicators of virus origin
There are three types of proteins in coronaviruses: nonstructural, structural, and accessory proteins. Coronavirus proteins are essential for viral...
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Complete genome sequence and phylogenetic analysis of a newly discovered fusagra-like virus infecting Carica papaya in Ecuador
A new fusagra-like virus infecting papaya ( Carica papaya L.) was genetically characterized. The genome of the virus, provisionally named "papaya...
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Complete nucleotide sequence of chrysanthemum virus D, a polero-like virus
A putative new polerovirus, named “chrysanthemum virus D” (ChVD), was detected in a Chrysanthemum morifolium plant in South Korea. The virus was...
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Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfer in vivo
Alveolar macrophages (AMs) are lung tissue-resident macrophages that can be expanded in culture, but it is unknown to what extent culture affects...
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Molecular characterization of birch toti-like virus, a plant-associated member of the new family Orthototiviridae
A novel totivirus, named "birch toti-like virus" (BTLV), was discovered in European white birch ( Betula pendula ) plants. The genome of BTLV is 4,967...
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A computational approach to analyse the amino acid variants of GLB1 protein causing GM1 Gangliosidosis
Lysosomal storage diseases comprise different forms of autosomal recessive disorders from which GM1 gangliosidosis has categorized by the...
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Tricarboxylic acid cycle metabolites: new players in macrophage
Metabolic remodeling is a key feature of macrophage activation and polarization. Recent studies have demonstrated the role of tricarboxylic acid...
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Homeobox genes and the specification of neuronal identity
The enormous diversity of cell types that characterizes any animal nervous system is defined by neuron-type-specific gene batteries that endow cells...
