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Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production
Aldosterone-producing adenomas (APAs) are the commonest curable cause of hypertension. Most have gain-of-function somatic mutations of ion channels...
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Genetic Polymorphisms in the Renin-Angiotensin-Aldosterone System
This chapter presents the evaluation of the impact of nonsynonymous single nucleotide polymorphisms (nsSNPs) in the renin-angiotensin-aldosterone...
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The ex vivo perfused mouse adrenal gland—a new model to study aldosterone secretion
Aldosterone is a steroid hormone that is important for maintaining the volume and ionic composition of extracellular fluids and is produced in the...
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Esaxerenone Inhibits Interferon-γ Induced Pyroptosis of Macrophages in the Lungs of Aldosterone-treated Mice
Lung immune cells such as lymphocytes and macrophages can induce an inflammatory response due to the activation of mineralocorticoid receptor (MR),...
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Somatic SLC30A1 mutations altering zinc transporter ZnT1 cause aldosterone-producing adenomas and primary aldosteronism
Primary aldosteronism (PA) is the most common form of endocrine hypertension and is characterized by inappropriately elevated aldosterone production...
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Renin–Angiotensin–Aldosterone System as an Old New Target in Heart Failure Therapy
The prevalence of heart failureHeart failure (HF) increases worldwide. Long-term maladaptive activation of the renin–angiotensin–aldosterone...
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Role of Renin Angiotensin-Aldosterone System in Kidney Homeostasis
The Renin-Angiotensin-Aldosterone System (RAAS), which regulates plasma sodium levels, arterial blood pressure, and extracellular volume, is a...
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Histamine H2-receptor antagonism improves conduit artery endothelial function and reduces plasma aldosterone level without lowering arterial blood pressure in angiotensin II–hypertensive mice
Aldosterone through the mineralocorticoid receptor MR has detrimental effects on cardiovascular disease. It reduces the bioavailability of nitric...
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An explorative epigenome-wide association study of plasma renin and aldosterone concentration in a Ghanaian population: the RODAM study
BackgroundThe epigenetic regulation of the renin–angiotensin–aldosterone system (RAAS) potentially plays a role in the pathophysiology underlying the...
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The renin angiotensin aldosterone system
In this review, we will cover (i) the proteolytic cascade of the RAAS, (ii) its regulation by multiple feedback-controlled parameters, and (iii) the...
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Renin-Angiotensin-Aldosterone System Role in Organ Fibrosis
The normal healing process secondary to injury, disease or toxins is a mandatory process to human life. The healing process begins with hemostasis,...
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A quantitative systems pharmacology model of plasma potassium regulation by the kidney and aldosterone
Plasma potassium regulation within a narrow range is vital for life. The risk for hyperkalemia increases when kidney function is impaired and with...
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The Classical and Nonclassical Renin-Angiotensin-Aldosterone System in Liver Cirrhosis
In chronic liver disease, excess hepatic deposition of extracellular matrix, the ensuing development of cirrhosis, the associated renal dysfunction,...
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The renin-angiotensin-aldosterone system (RAAS) signaling pathways and cancer: foes versus allies
The renin-angiotensin-aldosterone system (RAAS), is an old system with new fundamental roles in cancer biology which influences cell growth,...
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Low-salt diet increases mRNA expression of aldosterone-regulated transporters in the intermediate portion of the endolymphatic sac
The endolymphatic sac is a small sac-shaped organ at the end of the membranous labyrinth of the inner ear. The endolymphatic sac absorbs the...
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Renin–Angiotensin–Aldosterone System and LOX-1 Interaction in Hypertension with a Focus on Modulation of the Immune System
The renin–angiotensin–aldosterone systemRenin-angiotensin-aldosterone system (RAAS) plays a key role in the pathological process of many...
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Expression of Circulating Rennin—Angiotensin—Aldosterone-Related microRNAs in Patients with Thyrotoxic Heart Disease
Thyrotoxic heart disease (THD) is a common and severe complication of hyperthyroidism and the etiology of this complication remains poorly...
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Impact of ACE I gene insertion/deletion, A-240T polymorphisms and the renin–angiotensin–aldosterone system on COVID-19 disease
BackgroundThe coronavirus disease 2019 (COVID-19) pandemic is driven by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which...
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Unraveling the Differentially Articulated Axes of the Century-Old Renin–Angiotensin–Aldosterone System: Potential Therapeutic Implications
Among numerous choices in cardiovascular therapies used for the management of hypertension and heart failure, drugs affecting the...
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Understanding diabetes-induced cardiomyopathy from the perspective of renin angiotensin aldosterone system
Experimental and clinical evidence suggests that diabetic subjects are predisposed to a distinct cardiovascular dysfunction, known as diabetic...
