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The Axonal Actin Filament Cytoskeleton: Structure, Function, and Relevance to Injury and Degeneration
Early investigations of the neuronal actin filament cytoskeleton gave rise to the notion that, although growth cones exhibit high levels of actin...
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Emerging roles of deubiquitinating enzymes in actin cytoskeleton and tumor metastasis
BackgroundMetastasis accounts for the majority of cancer-related deaths. Actin dynamics and actin-based cell migration and invasion are important...
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CLDN6 inhibits breast cancer metastasis through WIP-dependent actin cytoskeleton-mediated autophagy
BackgroundAs a breast cancer suppressor gene, CLDN6 overexpression was found to inhibit breast cancer metastasis in our previous studies, but the...
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The Coordinating Role of the Actin Cytoskeleton in Short-Term Neural Network Plasticity Involving Excitatory and Inhibitory Synapses
The problem of frequency coding is closely related to studies of the mechanisms by which inhibitory interneurons are involved in neural network...
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Regeneration in calcareous sponge relies on ‘purse-string’ mechanism and the rearrangements of actin cytoskeleton
The crucial step in any regeneration process is epithelization, i.e. the restoration of an epithelium structural and functional integrity....
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HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling
BackgroundPeritoneal metastasis, which accounts for 85% of all epithelial ovarian carcinoma (EOC) metastases, is a multistep process that requires...
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Virus interactions with the actin cytoskeleton—what we know and do not know about SARS-CoV-2
The actin cytoskeleton and actin-dependent molecular and cellular events are responsible for the organization of eukaryotic cells and their...
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Coronavirus and the Cytoskeleton of Virus-Infected Cells
The cytoskeleton, which includes actin filaments, microtubules, and intermediate filaments, is one of the most important networks in the cell and...
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BioID Analysis of Actin-Binding Proteins
Proteins often exist and function as part of higher-order complexes or networks. A challenge is to identify the universe of proximal and interacting...
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Monitoring Cell Cytoskeleton Variations upon Piezoelectric Stimulation: Implications for the Immune System
Piezoelectric stimulation can have a significant impact on different cellular functions with possible applications in several fields, such as...
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Immunofluorescence study of cytoskeleton in endothelial cells induced with malaria sera
BackgroundEndothelial cells (ECs) play a major role in malaria pathogenesis, as a point of direct contact of parasitized red blood cells to the blood...
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Understanding Actin Remodeling in Neuronal Cells Through Podosomes
Cytoskeletal dysregulation forms an important aspect of many neurodegenerative diseases such as Alzheimer’s disease. Cytoskeletal functions require...
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A Ciliary Branched Actin Network Drives Photoreceptor Disc Morphogenesis
The light-detecting organelle of the photoreceptor cell is a modified primary cilium, called the outer segment. The outer segment houses hundreds of...
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Microglial Uptake of Extracellular Tau by Actin-Mediated Phagocytosis
Microglia are scavengers of the brain environment that clear dead cells, debris, and microbes. In Alzheimer’s disease, microglia get activated to...
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Regulation of fenestra formation via actin-dynamin2 interaction in rat pituitary endothelial cells
Endothelial fenestrae are transcellular pores divided by a diaphragm consisting of plasmalemma vesicle-associated protein (PLVAP). They function as a...
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Loss of SIL1 Affects Actin Dynamics and Leads to Abnormal Neural Migration
SIL1 is a nucleotide exchange factor for the molecular chaperone protein Bip in the endoplasmic reticulum that plays a crucial role in protein...
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PLCB1 Enhances Cell Migration and Invasion in Gastric Cancer Via Regulating Actin Cytoskeletal Remodeling and Epithelial–Mesenchymal Transition
Phospholipase C Beta 1 (PLCB1) regulates the abundance of PI(4,5)P2 in the plasma membrane and is implicated in various kinds of cancers. This study...
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Pelargonium sidoides extract mediates nephrotoxicity through mitochondrial malfunction and cytoskeleton destabilization
We investigated the cytotoxic effect of Pelargonium sidoides extract on Madin–Darby canine kidney (MDCK) cells. P. sidoides extract decreased the...
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A novel lncRNA ARST represses glioma progression by inhibiting ALDOA-mediated actin cytoskeleton integrity
BackgroundGlioma is one of the most aggressive malignant brain tumors that is characterized with inevitably infiltrative growth and poor prognosis....
