Search
Search Results
-
atoh8 expression pattern in early zebrafish embryonic development
Atonal homologue 8 ( atoh8 ) is a basic helix-loop-helix transcription factor expressed in a variety of embryonic tissues. While several studies have...
-
Long non-coding RNA CIR inhibits chondrogenic differentiation of mesenchymal stem cells by epigenetically suppressing ATOH8 via methyltransferase EZH2
BackgroundOsteoarthritis (OA) is the most common articular disorder, leading to joint malfunction and disability. Although the incidence of OA is...
-
Shear stress activates ATOH8 via autocrine VEGF promoting glycolysis dependent-survival of colorectal cancer cells in the circulation
BackgroundMetastasis and recurrence, wherein circulating tumour cells (CTCs) play an important role, are the leading causes of death in colorectal...
-
A spatiotemporal atlas of cholestatic injury and repair in mice
Cholestatic liver injuries, characterized by regional damage around the bile ductular region, lack curative therapies and cause considerable...
-
Lnc-PDZD7 contributes to stemness properties and chemosensitivity in hepatocellular carcinoma through EZH2-mediated ATOH8 transcriptional repression
BackgroundHepatocellular carcinoma (HCC) with stemness features are pivotal for tumorigenesis, chemoresistance, and progression. Long non-coding RNAs...
-
-
Survival mechanisms of circulating tumor cells and their implications for cancer treatment
Metastasis remains the principal trigger for relapse and mortality across diverse cancer types. Circulating tumor cells (CTCs), which originate from...
-
-
Long-term severe hypoxia adaptation induces non-canonical EMT and a novel Wilms Tumor 1 (WT1) isoform
The majority of cancer deaths are caused by solid tumors, where the four most prevalent cancers (breast, lung, colorectal and prostate) account for...
-
Analysis on EZH2: mechanism identification of related CeRNA and its immunoassay in hepatocellular carcinoma
ObjectiveTo screen the possible potential signaling pathways related to enhancer of zeste homolog 2 (EZH2) based on ceRNA mechanism, and to analyze...
-
Identification of the Shared Gene Signatures and Biological Mechanisms in Hyperplastic Enlarged Lobular Units and Breast Cancer
Breast cancer is a common cancer worldwide. Hyperplastic enlarged lobular units (HELUs) are common changes in the breasts of adult women. HELUs may...
-
LINC00853 contributes to tumor stemness of gastric cancer through FOXP3-mediated transcription of PDZK1IP1
BackgroundThe incidence and mortality of gastric cancer (GC) are high worldwide. Tumor stemness is a major contributor to tumorigenesis and...
-
Long Noncoding RNAs as Drivers of Acquired Chemoresistance in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. While recent improvements in the clinical management of HCC have...
-
Transcription factors-related molecular subtypes and risk prognostic model: exploring the immunogenicity landscape and potential drug targets in hepatocellular carcinoma
BackgroundHepatocellular carcinoma (HCC) is the most prevalent form of liver cancer, with a high mortality rate and poor prognosis. Mutated or...
-
Hypermethylation of the ADIRF promoter regulates its expression level and is involved in NNK-induced malignant transformation of lung bronchial epithelial cells
The carcinogenic mechanism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a well-known tobacco carcinogen, has not been fully elucidated in...
-
Stalled oligodendrocyte differentiation in IDH-mutant gliomas
BackgroundRoughly 50% of adult gliomas harbor isocitrate dehydrogenase ( IDH ) mutations. According to the 2021 WHO classification guideline, these...
-
EZH2-H3K27me3-mediated silencing of mir-139-5p inhibits cellular senescence in hepatocellular carcinoma by activating TOP2A
BackgroundEpigenetic alterations play an important role in hepatocellular carcinoma (HCC) development. Enhancer of zeste homolog 2 (EZH2) is a...
-
Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen
BackgroundAcute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis. Dysregulation of the epigenetic machinery is a significant...
-
Cathelicidin antimicrobial peptide (CAMP) gene promoter methylation induces chondrocyte apoptosis
ObjectiveThe occurrence of osteoarthritis is related to genetic and environmental factors. Among them, the change of chondrocyte gene expression...
-
Transient Polycomb activity represses developmental genes in growing oocytes
BackgroundNon-genetic disease inheritance and offspring phenotype are substantially influenced by germline epigenetic programming, including genomic...
