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Polyanhydride nanovaccine against H3N2 influenza A virus generates mucosal resident and systemic immunity promoting protection
Influenza A virus (IAV) causes significant morbidity and mortality worldwide due to seasonal epidemics and periodic pandemics. The antigenic...
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The biological characteristics and infection dynamics of a novel H3N2 canine influenza virus genotype in beagles
BackgroundThe canine influenza virus (CIV) outbreak has garnered considerable attention as it poses a significant threat to dog health. During the...
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Seasonal influenza vaccination expands hemagglutinin-specific antibody breadth to older and future A/H3N2 viruses
History of influenza A/H3N2 exposure, especially childhood infection, shape antibody responses after influenza vaccination and infection, but have...
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Antigenic drift and immunity gap explain reduction in protective responses against influenza A(H1N1)pdm09 and A(H3N2) viruses during the COVID-19 pandemic: a cross-sectional study of human sera collected in 2019, 2021, 2022, and 2023
BackgroundNon-pharmaceutical interventions implemented during the COVID-19 pandemic resulted in a marked reduction in influenza infections globally....
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Evaluation of the Effectiveness of Metabolites of Bacterial Strains Bacillus thuringiensis against Human Influenza Virus A/Aichi/2/68 (H3N2) In Vitro and In Vivo
The morphological and physiological characteristics of Bacillus thuringiensis strains were analyzed and conditions for obtaining culture fluid with...
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Phylogenetic analysis of HA and NA genes of influenza A viruses in immunosuppressed inpatients in Bei**g during the 2018–2020 influenza seasons
BackgroundInfluenza A viruses have undergone rapid evolution with virulent; however, complete and comprehensive data on gene evolution and amino acid...
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Immunogenicity of adjuvanted versus high-dose inactivated influenza vaccines in older adults: a randomized clinical trial
BackgroundAdjuvanted inactivated influenza vaccine (aIIV) and high-dose inactivated influenza vaccine (HD-IIV) are U.S.-licensed for adults...
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Targeting influenza A virus by splicing inhibitor herboxidiene reveals the importance of subtype-specific signatures around splice sites
BackgroundThe association between M segment splicing and pathogenicity remains ambiguous in human influenza A viruses. In this study, we aimed to...
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Transmission and pathogenicity of canine H3N2 influenza virus in dog and guinea pig models
BackgroundInfluenza A virus causes respiratory disease in many animal species as well as in humans. Due to the high human-animal interface, the...
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Immunization with matrix-, nucleoprotein and neuraminidase protects against H3N2 influenza challenge in pH1N1 pre-exposed pigs
There is an urgent need for influenza vaccines providing broader protection that may decrease the need for annual immunization of the human...
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An epitope-optimized human H3N2 influenza vaccine induces broadly protective immunity in mice and ferrets
There is a crucial need for an improved H3N2 influenza virus vaccine due to low vaccine efficacy rates and increased morbidity and mortality...
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A polyvalent virosomal influenza vaccine induces broad cellular and humoral immunity in pigs
BackgroundInfluenza A virus (IAV) is endemic in pigs globally and co-circulation of genetically and antigenically diverse virus lineages of subtypes...
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Immunological profile of mice immunized with a polyvalent virosome-based influenza vaccine
BackgroundInfluenza A virus (IAV) causes respiratory disease in pigs and is a major concern for public health. Vaccination of pigs is the most...
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DYNAMIC cohort study evaluating metabolic predictors of influenza vaccine immune response in older adults
Immunosenescence (age-related immune dysfunction) and inflamm-aging contribute to suboptimal immune responses in older adults to standard-dose...
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Nanoparticle display of neuraminidase elicits enhanced antibody responses and protection against influenza A virus challenge
Current Influenza virus vaccines primarily induce antibody responses against variable epitopes in hemagglutinin (HA), necessitating frequent updates....
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Influenza virus infection history shapes antibody responses to influenza vaccination
Studies of successive vaccination suggest that immunological memory against past influenza viruses may limit responses to vaccines containing current...
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Self-amplifying mRNA seasonal influenza vaccines elicit mouse neutralizing antibody and cell-mediated immunity and protect ferrets
Currently licensed influenza vaccines focus immune responses on viral hemagglutinin (HA), while the other major surface glycoprotein neuraminidase...
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Systemic prime mucosal boost significantly increases protective efficacy of bivalent RSV influenza viral vectored vaccine
Although licensed vaccines against influenza virus have been successful in reducing pathogen-mediated disease, they have been less effective at...
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Anti-Influenza Activity of Cetraria islandica Lichen Extracts in In Vitro Experiments
The toxicity and antiviral activity of extracts obtained by the methods of aqueous and ethanol extraction of bioactive substances from Cetraria...