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5,6- and 5,7-Dihydroxytryptamines as Serotoninergic Neurotoxins
Dihydroxytryptamines are able to selectively destroy central serotonin neurons when catecholaminergic neurons are protected. Compared to serotonin,...
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Survey of Selective Monoaminergic Neurotoxins Targeting Dopaminergic, Noradrenergic, and Serotoninergic Neurons
The concept of selective neurotoxicity was highlighted in the 1930s by the noted Physiologist Walter Canon who promoted the concept of “absence...
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Survey of Selective Monoaminergic Neurotoxins Targeting Dopaminergic, Noradrenergic, and Serotoninergic Neurons
The concept of selective neurotoxicity was highlighted in the 1930s by the noted Physiologist Walter Canon who promoted the concept of “absence...
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p-Chloroamphetamine-Enhanced Neostriatal Dopamine Exocytosis in Rats Neonatally Co-lesioned with 6-OHDA and 5,7-DHT: Relevance to Parkinson’s Disease
Serotoninergic nerves are known to modulate sensitization of dopamine receptors (DA-R) in a rodent model of Parkinson’s disease (PD). However,...
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Long-Lived Dopamine D2-Receptor Supersensitivity: Neurotoxicity in the Presence and Absence of Neuronal Damage
Overt destruction of a nerve by a highly selective neurotoxin produces an accompanying loss of function. However, the abnormality of nerve loss is...
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Long-Lived Dopamine D2-Receptor Supersensitivity: Neurotoxicity in the Presence and Absence of Neuronal Damage
Overt destruction of a nerve by a highly selective neurotoxin produces an accompanying loss of function. However, the abnormality of nerve loss is...
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Tardive Dyskinesia: Outcome of Antipsychotic Treatment and Brain Damage?
Tardive dyskinesia (TD), frequently expressed as excessive perioral activity, represents an adverse outcome of prolonged antipsychotic treatments,...
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Tardive Dyskinesia: Outcome of Antipsychotic Treatment and Brain Damage?
Tardive dyskinesia (TD), frequently expressed as excessive perioral activity, represents an adverse outcome of prolonged antipsychotic treatments,...
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The diverse role of the raphe 5-HTergic systems in epilepsy
The raphe nuclei comprise nearly all of 5-hydroxytryptaminergic (5-HTergic) neurons in the brain and are widely acknowledged to participate in the...
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Contribution of Transglutaminase to the Induction and Maintenance of Long-Term Synaptic Potentiation in Neurons in the Common Snail
Previous studies have shown that the neurotransmitter serotonin is required for the successful formation of long-term potentiation in the terrestrial...
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Synthesis of Dopamine by Non-Dopaminergic Neurons Containing Aromatic Amino Acid Decarboxylase in the Suprachiasmatic Nucleus of Rats in Ontogeny
Abstract —The suprachiasmatic nucleus (SCN) regulates functions in accordance with circadian rhythms thanks to the pacemaker neurons present in it and...
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The Influence of the Microbiota on Brain Structure and Function: Implications for Stress-Related Neuropsychiatric Disorders
Based on research conducted during the last decade, it is becoming clear that the human microbiota plays an important role in the maintenance of...
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Induction of aberrant agonistic behavior by a combination of serotonergic and dopaminergic manipulation in rats
Serotonin (5-HT) and dopamine (DA) are involved in the regulation of social behaviors. However, the effects of their interactions on social behavior...
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A pontomesencephalic PACAPergic pathway underlying panic-like behavioral and somatic symptoms in mice
Panic disorder is characterized by uncontrollable fear accompanied by somatic symptoms that distinguish it from other anxiety disorders. Neural...
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Cognitive Inflexibility in OCD and Related Disorders
Cognitive inflexibility is suggested by the hallmark symptoms of obsessive-compulsive disorder (OCD), namely the occurrence of repetitive thoughts...
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6-Hydroxydopamine Lesioning of Dopamine Neurons in Neonatal and Adult Rats Induces Age-Dependent Consequences
Over 45 years ago, it was discovered that the compound 6-hydroxydopamine (6-OHDA) destroys catecholamine (CA)-containing neurons when injected...
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Serotonin and beyond—a tribute to Manfred Göthert (1939-2019)
Manfred Göthert, who had served Naunyn-Schmiedeberg’s Arch Pharmacol as Managing Editor from 1998 to 2005, deceased in June 2019. His scientific...
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Behavioral and neurochemical interactions of the tricyclic antidepressant drug desipramine with L-DOPA in 6-OHDA-lesioned rats. Implications for motor and psychiatric functions in Parkinson’s disease
RationaleThe pharmacological effects of antidepressants in modulating noradrenergic transmission as compared to serotonergic transmission in a rat...
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Sequential reversal learning: a new touchscreen schedule for assessing cognitive flexibility in mice
RationaleThe widespread deficits in cognitive flexibility observed across psychiatric disorders call for improved rodent tests to understand the...
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Serotonin augmentation therapy by escitalopram has minimal effects on amyloid-β levels in early-stage Alzheimer’s-like disease in mice
BackgroundDysfunction of the serotonergic (5-HTergic) system has been implicated in the cognitive and behavioural symptoms of Alzheimer’s disease...
