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Impact of 1α,25-dihydroxyvitamin D3 on biodistribution and pharmacokinetics of L-carnitine and creatinine, organic cation/carnitine transporter 2 and organic cation transporter 2 biomarkers
PurposeThis study investigated effects of 1α,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ] on biodistribution and pharmacokinetics of L-carnitine and...
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Effects of 1α,25-dihydroxyvitamin D3 on the pharmacokinetics and biodistribution of ergothioneine, an endogenous organic cation/carnitine transporter 1 substrate, in rats
PurposeThis study aimed to investigate the effects of 1α,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ) on the expression levels of organic cation/carnitine...
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1α,25-dihydroxyvitamin D3 protects retinal ganglion cells in glaucomatous mice
BackgroundGlaucoma is an optic neuropathy characterized by loss of function and death of retinal ganglion cells (RGCs), leading to irreversible...
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Emerging perspectives: unraveling the anticancer potential of vitamin D3
Vitamin D 3 , a fat-soluble vitamin known for its critical function in calcium homeostasis and bone health, is gaining interest for its anticancer...
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Significance of the Vitamin D Receptor on Crosstalk with Nuclear Receptors and Regulation of Enzymes and Transporters
The vitamin D receptor (VDR), in addition to other nuclear receptors, the pregnane X receptor (PXR) and constitutive androstane receptor (CAR), is...
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Neuroinflammation in Alzheimer’s disease: potential beneficial effects of vitamin D
Alzheimer’s disease (AD) is the most common cause of dementia. In recent years, several studies have robustly shown that neuroinflammation plays a...
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25-Hydroxyvitamin D potentializes extracellular cathelicidin release from human PBMC stimulated ex vivo with either bacterial (LPS) or viral (P: IC) mimetics
Human cathelicidin refers to the cationic antimicrobial peptide hCAP18/LL-37. LL-37 is formed by cleavage of the propeptide hCAP18 coded by the CAMP ...
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Association of DNA methylation of vitamin D metabolic pathway related genes with colorectal cancer risk
BackgroundVitamin D might have anti-tumor effect, which is affected by the genes related to vitamin D metabolic pathway. Epigenetic mechanism may...
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Role of Neural Stem Cells and Vitamin D Receptor (VDR)–Mediated Cellular Signaling in the Mitigation of Neurological Diseases
Specific stem cell–based therapies for treating Alzheimer’s disease, Parkinson’s disease, and schizophrenia are gaining importance in recent years....
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Vitamin D as a modifiable risk factor, predictor, and theoretical therapeutic agent for vasospasm in spontaneous subarachnoid hemorrhage
Delayed deterioration associated with cerebral vasospasm (CVS) is a feared complication after spontaneous subarachnoid hemorrhage (SAH) and is one of...
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Circulating vitamin D level before initiating chemotherapy impacts on the time-to-outcome in metastatic colorectal cancer patients: systematic review and meta-analysis
BackgroundVitamin D (VD) is implicated in various health conditions, including colorectal cancer (CRC). To investigate potential relationships...
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Phosphate, Calcium, and Vitamin D: Key Regulators of Fetal and Placental Development in Mammals
Normal calciumCalcium and bone homeostasis in the adult is virtually fully explained by the interactions of several key regulatory hormones,...
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Strategies for the Design of Vitamin D Receptor Ligands
Structure-activity relationship analysis is a powerful tool to elucidate the structural requirements for high-affinity vitamin D receptor (VDR)...
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The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson’s disease
In recent years, many studies have investigated the correlations between Parkinson’s disease (PD) and vitamin D status, but the conclusion remains...
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The role of vitamin D in autoimmune diseases: could sex make the difference?
Over the last decades, a central role for vitamin D in immune modulation has been well established. The active form of vitamin D, i.e.,...
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Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells
The molecular mechanisms governing orderly shutdown and retraction of CD4 + type 1 helper T (T H 1) cell responses remain poorly understood. Here we...
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Vitamin D and connective tissue diseases
Objective and designRecently, many studies have shown that the biologically active form of vitamin D—1,25(OH) 2 D—is involved in many biological...
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Gut microbiome, Vitamin D, ACE2 interactions are critical factors in immune-senescence and inflammaging: key for vaccine response and severity of COVID-19 infection
BackgroundThe SARS-CoV-2 pandemic continues to spread sporadically in the Unites States and worldwide. The severity and mortality excessively...
