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Autophagy activity contributes to the impairment of social recognition in Epac2−/− mice
Autophagy is a lysosomal degradation pathway that regulates cellular homeostasis. It is constitutively active in neurons and controls the essential...
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Acid-Sensing Ion Channels Contribute to Type III Adenylyl Cyclase–Independent Acid Sensing of Mouse Olfactory Sensory Neurons
Acids can disturb the ecosystem of wild animals through altering their olfaction and olfaction-related survival behaviors. It is known that the main...
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Basolateral amygdala and orbitofrontal cortex, but not dorsal hippocampus, are necessary for the control of reward-seeking by occasion setters
Reward-seeking in the world is driven by cues that can have ambiguous predictive and motivational value. To produce adaptive, flexible...
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Liraglutide versus pramlintide in protecting against cognitive function impairment through affecting PI3K/AKT/GSK-3β/TTBK1 pathway and decreasing Tau hyperphosphorylation in high-fat diet- streptozocin rat model
The American Diabetes Association guidelines (2021) confirmed the importance of raising public awareness of diabetes-induced cognitive impairment,...
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Adult Neurogenesis and Social Behavior: A Reciprocal Relationship
Neural plasticity refers to the brain’s life-long capacity to change itself functionally and structurally. Specifically, adult neurogenesis—a unique...
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Pharmacological inhibition of plasminogen activator inhibitor-1 prevents memory deficits and reduces neuropathology in APP/PS1 mice
RationaleExtracellular proteolytic activity plays an important role in memory formation and the preservation of cognitive function. Previous studies...
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Extrinsic neuromodulation in the rodent olfactory bulb
Evolutionarily, olfaction is one of the oldest senses and pivotal for an individual’s health and survival. The olfactory bulb (OB), as the first...
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Olfactory coding in honeybees
With less than a million neurons, the western honeybee Apis mellifera is capable of complex olfactory behaviors and provides an ideal model for...
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Disentangling the acute subjective effects of classic psychedelics from their enduring therapeutic properties
Recent research with classic psychedelics suggests significant therapeutic potential, particularly for neuropsychiatric disorders. A mediating...
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TrkB-mediated sustained neuroprotection is sex-specific and \(\text{ER}\alpha\)-dependent in adult mice following neonatal hypoxia ischemia
BackgroundNeonatal hypoxia ischemia (HI) related brain injury is one of the major causes of life-long neurological morbidities that result in...
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Involvement of Microbiome Gut–Brain Axis in Neuroprotective Effect of Quercetin in Mouse Model of Repeated Mild Traumatic Brain Injury
Repeated mild traumatic brain injury (rmTBI) poses adversity in the form of neurological deficits. The ignition of long-term neurological aberrations...
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Emotion, motivation, decision-making, the orbitofrontal cortex, anterior cingulate cortex, and the amygdala
The orbitofrontal cortex and amygdala are involved in emotion and in motivation, but the relationship between these functions performed by these...
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Therapeutic Effects of High-Intensity Interval Training Exercise Alone and Its Combination with Ecdysterone Against Amyloid Beta-Induced Rat Model of Alzheimer’s Disease: A Behavioral, Biochemical, and Histological Study
Hippocampal oxidative stress has a vital role in the pathophysiology of Alzheimer’s disease (AD)-associated behavioral deficits. Ecdysterone (Ecdy),...
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Fecal Volatile Organic Compounds
Fecal volatile organic compounds (VOCs) are a burgeoning field of study as a biomarker of both normal human physiology and disease states. The...
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Preclinical Models of Relapse to Psychostimulants Induced by Environmental Stimuli
A major aim of addiction research is the understanding of the pathophysiological profile of relapse risk and the development of treatments for...
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Caffeine Consumption plus Physical Exercise Improves Behavioral Impairments and Stimulates Neuroplasticity in Spontaneously Hypertensive Rats (SHR): an Animal Model of Attention Deficit Hyperactivity Disorder
Attention deficit hyperactivity disorder (ADHD) is a prevalent and disabling disorder, mainly characterized by hyperactivity, inattention, and...
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Fecal Volatile Organic Compounds
Fecal volatile organic compounds (VOCs) are a burgeoning field of study as a biomarker of both normal human physiology and disease states. The...
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Nicotine restores olfactory function by activation of prok2R/Akt/FoxO3a axis in Parkinson’s disease
BackgroundOlfactory dysfunction occurs frequently in Parkinson’s disease (PD). In this study, we aimed to explore the potential biomarkers and...
