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Platelet-activating factor acetyl hydrolase IB2 dysregulated cell proliferation in ovarian cancer
BackgroundOvarian cancer is the leading cause of death from gynaecologic illnessed worldwide. Platelet-activating factor acetyl hydrolase IB2 (PAF-AH...
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Creation of Philadelphia chromosome by CRISPR/Cas9-mediated double cleavages on BCR and ABL1 genes as a model for initial event in leukemogenesis
The Philadelphia (Ph) chromosome was the first translocation identified in leukemia. It is supposed to be generated by aberrant ligation between two...
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Role of non-coding RNA in immune microenvironment and anticancer therapy of gastric cancer
Gastric cancer remains one of the cancers with the highest mortality in the world; therefore, it is very important to investigate its pathogenesis to...
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SOX1 Is a Backup Gene for Brain Neurons and Glioma Stem Cell Protection and Proliferation
Failed neuroprotection leads to the initiation of several diseases. SOX1 plays many roles in embryogenesis, oncogenesis, and male sex determination,...
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Distal Onco-Sphere: The Origin and Overview of Cancer Metastasis
In current cancer statistics, most cancer patients died of metastasis and not of primary tumors. Therefore, metastasis could be categorized as a...
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Ficolin 3 promotes ferroptosis in HCC by downregulating IR/SREBP axis-mediated MUFA synthesis
BackgroundTargeting ferroptosis has been identified as a promising approach for the development of cancer therapies. Monounsaturated fatty acid...
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Integrating thousands of PTEN variant activity and abundance measurements reveals variant subgroups and new dominant negatives in cancers
BackgroundPTEN is a multi-functional tumor suppressor protein regulating cell growth, immune signaling, neuronal function, and genome stability....
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Enzootic nasal tumor virus type 2 envelope of goats acts as a retroviral oncogene in cell transformation
Enzootic nasal tumor virus type 1 (ENTV-1) (ovine nasal tumor virus) and ENTV-2 (caprine nasal tumor virus) are known to be causative agents of...
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An Introduction to Recent Approaches Underlying Mechanistic Insights Harboring Oncobiology
The field of oncobiology is witnessing rapid progress, with numerous ongoing studies dedicated to comprehending the intricate mechanisms underlying...
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A guardian turned rogue: TP53 promoter translocations rewire stress responses to oncogenic effectors in osteosarcoma
Osteosarcoma is the most prevalent malignant bone tumour in children, adolescents and young adults. Despite a multitude of aberrations present in...
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Is cancer a disease set up by cellular stress responses?
For several decades, the somatic mutation theory (SMT) has been the dominant paradigm on cancer research, leading to the textbook notion that cancer...
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Association of Oxidative Stress and Mitochondrial Dysfunction to Gynecological Malignancies
Despite years of concerted research, gynecological malignanciesGynecological malignancies have remained a persistent cause of morbidity and mortality...
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MicroRNA-665 facilitates cell proliferation and represses apoptosis through modulating Wnt5a/β-Catenin and Caspase-3 signaling pathways by targeting TRIM8 in LUSC
BackgroundMicroRNAs (miRNAs) are involved in the oncogenesis, development and transformation of lung squamous cell carcinoma (LUSC). miR-665 is...
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Hippo pathway effectors YAP and TAZ and their association with skeletal muscle ageing
Skeletal muscle atrophy commonly occurs during ageing, thus pathways that regulate muscle mass may represent a potential therapeutic avenue for...
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Insights into recent findings and clinical application of YAP and TAZ in cancer
Decades of research have mapped out the basic mechanics of the Hippo pathway. The paralogues Yes-associated protein (YAP) and transcriptional...
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The role of TBK1 in cancer pathogenesis and anticancer immunity
The TANK-binding kinase 1 (TBK1) is a serine/threonine kinase belonging to the non-canonical inhibitor of nuclear factor-κB (IκB) kinase (IKK)...
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EZH2 K63-polyubiquitination affecting migration in extranodal natural killer/T-cell lymphoma
BackgroundOverexpressed EZH2 is oncogenically involved in the pathogenesis of different cancerous contexts including extranodal natural killer/T cell...
