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Nitric oxide debilitates the neuropathogenic schistosome Trichobilharzia regenti in mice, partly by inhibiting its vital peptidases
BackgroundAvian schistosomes, the causative agents of human cercarial dermatitis (or swimmer’s itch), die in mammals but the mechanisms responsible...
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Sepsis-Induced Inhibition of Contractile Function of Lymphatic Nodes
Inflammation accompanies most pathological processes, while the lymphatic system takes part in both the development and resolution of inflammation....
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Expression Level of the Nos2 and Nfkb1 Genes in the Conditions of Esophageal Alkaline Burns and with the Administration of Melanin
AbstractIn this study, an increase in the expression level of the proinflammatory Nos2 and Nfkb1 genes in blood and the esophageal mucus under the...
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Effect of Hematopoietic Stem Cell Transplantation and Post-Transplantation Cyclophosphamide on the Microglia Phenotype in Rats with Experimental Allergic Encephalomyelitis
Microglia are the resident immune cells of the central nervous system, playing a role in the inflammatory process development and resolution,...
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Bioactive fraction from Plumeria obtusa L. attenuates LPS-induced acute lung injury in mice and inflammation in RAW 264.7 macrophages: LC/QToF-MS and molecular docking
In this study, the anti-inflammatory effects of the methanolic extract (TE) of Plumeria obtusa L. (aerial parts) and its fractions were evaluated in...
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Inducible Prmt1 ablation in adult vascular smooth muscle leads to contractile dysfunction and aortic dissection
Vascular smooth muscle cells (VSMCs) have remarkable plasticity in response to diverse environmental cues. Although these cells are versatile,...
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Tumor Microenvironment and Nitric Oxide: Concepts and Mechanisms
The cancer tissue exists not as a single entity, but as a combination of different cellular phenotypes which, taken together, dramatically contribute...
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Changes in nitric oxide synthase levels are associated with impaired cardiac function and tolerance to ischemia-reperfusion injury in male rats with transient congenital hypothyroidism
Transient congenital hypothyroidism (TCH) has long-lasting consequences on the cardiovascular system during adulthood. The aim of this study was to...
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Stable Gastric Pentadecapeptide BPC 157 and NO-System
Stable gastric pentadecapeptide BPC 157 is known with very safe profile when used to be in ulcerative colitis and now multiple sclerosis trial,...
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Endoplasmic reticulum stress-induced NLRP3 inflammasome activation as a novel mechanism of polystyrene microplastics (PS-MPs)-induced pulmonary inflammation in chickens
Microplastics (MPs) have attracted growing attention worldwide as an increasingly prevalent environmental pollutant. In addition, chicken meat is...
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The Acute Effect of Trimethylamine-N-Oxide on Vascular Function, Oxidative Stress, and Inflammation in Rat Aortic Rings
A growing body of evidence suggests that the gut microbiota affects the cardiovascular system directly and indirectly via biologically active...
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Protective effect of hydrogen sulfide against stress-induced lung injury: involvement of Nrf2, NFκB/iNOS, and HIF-1α signaling pathways
Stress is a common phenomenon that is attracting increasing attention. Hydrogen sulfide (H 2 S) is a gasotransmitter that plays an important role in...
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Inhibition of Neuronal Nitric Oxide Synthase by Ethyl Pyruvate in Schwann Cells Protects Against Peripheral Nerve Degeneration
Schwann cells are essential glial cells in the peripheral nervous system (PNS), and dysfunction of Schwann cells can induce various peripheral...
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Nitric oxide synthase and VEGF expression in full-term placentas of obese women
An adequate placental vascularization allows the proper development of the fetus and it is crucial for the gestational success. A number of factors...
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Study on peripheral antinociception induced by hydrogen peroxide (H2O2): characterization and mechanisms
The present study aimed to evaluate the possible peripheral H 2 O 2 -induced antinociception and determine the involvement of opioidergic,...
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Gaseous Signaling in the Central Nervous System
Gasotransmission is a form of cell-to-cell communication that relies on the endogenous generation of small gaseous molecules. Currently three...
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Scutellarin prevents acute alcohol-induced liver injury via inhibiting oxidative stress by regulating the Nrf2/HO-1 pathway and inhibiting inflammation by regulating the AKT, p38 MAPK/NF-κB pathways
Alcoholic liver disease (ALD) is the most frequent liver disease worldwide, resulting in severe harm to personal health and posing a serious burden...
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Neuroprotective effects of carvacrol against cadmium-induced neurotoxicity in rats: role of oxidative stress, inflammation and apoptosis
Cadmium (Cd), is a heavy metal reported to be associated with oxidative stress and inflammation. In this paper, we investigated the possible...
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Nuciferine attenuates lipopolysaccharide-stimulated inflammatory responses by inhibiting p38 MAPK/ATF2 signaling pathways
Nuciferine, isolated from Nelumbo nucifera (commonly known as lotus) leaves, has been shown to have beneficial effects, including antioxidant,...
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Nanosilver alleviates foreign body reaction and facilitates wound repair by regulating macrophage polarization
Foreign body reactions induced by macrophages often cause delay or failure of wound healing in the application of tissue engineering scaffolds. This...