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Effect of connective tissue growth factor gene editing using adeno-associated virus–mediated CRISPR–Cas9 on rabbit glaucoma filtering surgery outcomes
Suppressing excessive wound healing responses is critical to ensure surgical success in glaucoma filtration surgery (GFS). Currently used adjunctive...
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Genome-wide analysis of genetic pleiotropy and causal genes across three age-related ocular disorders
Age-related macular degeneration (AMD), cataract, and glaucoma are leading causes of blindness worldwide. Previous genome-wide association studies...
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Extracellular vesicle encapsulated nicotinamide delivered via a trans-scleral route provides retinal ganglion cell neuroprotection
The progressive and irreversible degeneration of retinal ganglion cells (RGCs) and their axons is the major characteristic of glaucoma, a leading...
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Application of Biocompatible Nanocarriers in Glaucoma: Challenges and Advances
Glaucoma is a serious and complex eye disorder with worldwide occurrence in the aging societies and if left untreated at a precise time may lead to...
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Deep learning approaches based improved light weight U-Net with attention module for optic disc segmentation
Glaucoma is a major cause of blindness worldwide, and its early detection is essential for the timely management of the condition. Glaucoma-induced...
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Cell-Specific Expression of Human SIRT1 by Gene Therapy Reduces Retinal Ganglion Cell Loss Induced by Elevated Intraocular Pressure
SIRT1 prevents retinal ganglion cell (RGC) loss in several acute and subacute optic neuropathy models following pharmacologic activation or genetic...
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Correlations Between Renal Biomarkers and the Treatment Outcomes in Diabetes: Ophthalmic Aspects
Diabetic retinopathy (DR) and diabetic nephropathy are the main microvascular complications in diabetes and often comorbid with each other. Renal...
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Association analysis of polymorphisms rs12997 in ACVR1 and rs1043784 in BMP6 genes involved in bone morphogenic protein signaling pathway in primary angle-closure and pseudoexfoliation glaucoma patients of Saudi origin
BackgroundGlaucoma is a polygenic neurodegenerative disease and the second most common cause of blindness in Saudi Arabia. To test the hypothesis...
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Viral Vector-Induced Ocular Hypertension in Mice
Viral transduction of the mouse trabecular meshwork using a variety of transgenes associated with glaucoma generates an inducible and reproducible...
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Enhancing the hypotensive effect of latanoprost by combining synthetic phosphatidylcholine liposomes with hyaluronic acid and osmoprotective agents
The first line of glaucoma treatment focuses on reducing intraocular pressure (IOP) through the prescription of topical prostaglandin analogues, such...
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CPAMD8 loss-of-function underlies non-dominant congenital glaucoma with variable anterior segment dysgenesis and abnormal extracellular matrix
Abnormal development of the ocular anterior segment may lead to a spectrum of clinical phenotypes ranging from primary congenital glaucoma (PCG) to...
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Screening Methods for the Evaluation of Antiglaucoma and Anticataract Drugs
Glaucoma and cataract are the most common ophthalmic conditions that can lead to visual impairment and eventually blindness, if untreated. Visual...
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Exploring Penetration Ability of Carbonic Anhydrase Inhibitor–Loaded Ultradeformable Bilosome for Effective Ocular Application
Brinzolamide is an effective carbonic anhydrase inhibitor widely used in glaucoma therapy but limits its application due to inadequate aqueous...
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Dysregulation of neuroprotective lipoxin pathway in astrocytes in response to cytokines and ocular hypertension
Glaucoma leads to vision loss due to retinal ganglion cell death. Astrocyte reactivity contributes to neurodegeneration. Our recent study found that...
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Association of IL-10 gene promoter polymorphisms with susceptibility to pseudoexfoliation syndrome, pseudoexfoliative and primary open-angle glaucoma
BackgroundThe involvement of cytokines in pathogenesis of pseudoexfoliation syndrome and glaucoma has been demonstrated in several studies. The aim...
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Adaptive weighted locality-constrained sparse coding for glaucoma diagnosis
Glaucoma is a sight-threading disease which can lead to irreversible blindness. Currently, extracting the vertical cup-to-disc ratio (CDR) from 2D...
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Retinal Ganglion Cells in a Dish: Current Strategies and Recommended Best Practices for Effective In Vitro Modeling of Development and Disease
The ability to derive retinal ganglion cells (RGCs) from human pluripotent stem cells (hPSCs) provides an extraordinary opportunity to study the...
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Solving neurodegeneration: common mechanisms and strategies for new treatments
Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or regeneration,...
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High-Throughput Binocular Pattern Electroretinograms in the Mouse
The pattern electroretinogram (PERG) reflects the electrical activity of retinal ganglion cells (RGC) and has become the most used technology to...
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TRPV4-induced Müller cell gliosis and TNF-α elevation-mediated retinal ganglion cell apoptosis in glaucomatous rats via JAK2/STAT3/NF-κB pathway
BackgroundGlaucoma, the leading cause of irreversible blindness worldwide, is a type of retinal disease characterized by the selective death of...
