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Synthetic Migrastatic: A New Class of Anticancer Drug
Cancer remains one of the fatal diseases in the last century. The mortality rate of different types of cancer is mainly related to metastasis, where...
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The Role of Inflammasomes in the Pathogenesis of Neurodegenerative Diseases
Abstract —Protein misfolding and accumulation of protein aggregates is a distinctive feature of most neurodegenerative diseases. They lead to...
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CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states
Astrocytes become reactive in response to insults to the central nervous system by adopting context-specific cellular signatures and outputs, but a...
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Macrophage phagocytosis of SARS-CoV-2-infected cells mediates potent plasmacytoid dendritic cell activation
Early and strong interferon type I (IFN-I) responses are usually associated with mild COVID-19 disease, whereas persistent or unregulated...
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Viscoelastic Hemostatic Tests and Fibrinogen Concentrations in Trauma
Thrombelastography (TEG) and rotational thromboelastometry (ROTEM) are used to diagnose trauma-induced coagulopathy, fibrinogen deficiency, and guide...
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Effect of GNE Mutations on Cytoskeletal Network Proteins: Potential Gateway to Understand Pathomechanism of GNEM
GNE myopathy is an inherited neuromuscular disorder caused by mutations in GNE (UDP- N -acetylglucosamine 2-epimerase/ N -acetyl mannosamine kinase) gene...
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Inhibition of PFKFB3 in HER2-positive gastric cancer improves sensitivity to trastuzumab by inducing tumour vessel normalisation
BackgroundMultiple mechanisms have been proposed that lead to reduced effectiveness of trastuzumab in HER2-positive gastric cancer (GC), yet...
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Inhibition of microglial β-glucocerebrosidase hampers the microglia-mediated antioxidant and protective response in neurons
BackgroundHomozygotic mutations in the GBA gene cause Gaucher’s disease; moreover, both patients and heterozygotic carriers have been associated with...
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Structure, function and regulation of mammalian glucose transporters of the SLC2 family
The SLC2 genes code for a family of GLUT proteins that are part of the major facilitator superfamily (MFS) of membrane transporters. Crystal...
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Assessment of Peripheral Blood Lymphocytes in Parents of Autistic Children by Cytokinesis Block Micronucleus Assay
Autism spectrum disorders are neurodevelopmental complex diseases with causative de-novo and inherited genetic factors. They include a range of...
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Src kinase inhibition with dasatinib impairs neutrophil function and clearance of Escherichia coli infection in a murine model of acute lung injury
BackgroundNeutrophils rapidly respond to and clear infection from tissues, but can also induce tissue damage through excessive degranulation, when...
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Development of reconstructed intestinal micronucleus cytome (RICyt) assay in 3D human gut model for genotoxicity assessment of orally ingested substances
The micronucleus (MN) assay is widely used as part of a battery of tests applied to evaluate the genotoxic potential of chemicals, including new food...
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The Reorganization of the Actin Matrix as a Factor of Presynaptic Plasticity
Abstract —We review modern concepts on the mechanisms of actin involvement in coordination of presynaptic functions. In addition to the role of the...
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Genotoxicity of Psychotropic Drugs in Experimental and Clinical Studies
Data from studies of the genotoxic activity of psychotropic drugs published over the past 25 years were analyzed. Information describing the...
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Induction of T-helper-17-cell-mediated anti-tumour immunity by pathogen-mimicking polymer nanoparticles
The effectivity of cancer immunotherapies is hindered by immunosuppressive tumour microenvironments that are poorly infiltrated by effector T cells...
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Human ACE2 protein is a molecular switch controlling the mode of SARS-CoV-2 transmission
BackgroundHuman angiotensin-converting enzyme 2 (hACE2) is the receptor mediating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)...
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Mitochondria as secretory organelles and therapeutic cargos
Mitochondria have been primarily considered intracellular organelles that are responsible for generating energy for cell survival. However,...
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A novel DENND1B-localized structure found at the basal side of adherent cells
Rab35 is a small G protein involved in various cellular events including clathrin-dependent endocytosis, phagocytosis, and autophagy. DENND1B, a DENN...
