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Erythropoietin regulates signaling pathways associated with neuroprotective events
Erythropoietin is a cytokine that binds to the Erythropoietin receptor and regulates the formation of erythroid cells during erythropoiesis in the...
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Unraveling Dysregulated Cell Signaling Pathways, Genetic and Epigenetic Mysteries of Parkinson’s Disease
AbstractParkinson's disease (PD) is a prevalent and burdensome neurodegenerative disorder that has been extensively researched to understand its...
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Tumor-secreted IFI35 promotes proliferation and cytotoxic activity of CD8+ T cells through PI3K/AKT/mTOR signaling pathway in colorectal cancer
BackgroundA large proportion of the patients with cancer do not respond to immunotherapies. Recent studies suggested an important role for...
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ADAM12 promotes clear cell renal cell carcinoma progression and triggers EMT via EGFR/ERK signaling pathway
BackgroundClear cell renal cell carcinoma (ccRCC) is a major worldwide health problem due to its high prevalence and mortality rate. A disintegrin...
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Targeting macrophagic PIM-1 alleviates osteoarthritis by inhibiting NLRP3 inflammasome activation via suppressing mitochondrial ROS/Cl− efflux signaling pathway
BackgroundOsteoarthritis (OA), in which macrophage-driven synovitis is considered closely related to cartilage destruction and could occur at any...
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Cancer Pathways
Proliferation, differentiation, and survival of normal cells are regulated by interlinked pathways that transmit and integrate signals from growth...
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METTL3 facilitates stemness properties and tumorigenicity of cancer stem cells in hepatocellular carcinoma through the SOCS3/JAK2/STAT3 signaling pathway
Liver cancer stem cells (LCSCs) contribute to tumor recurrence and cancer cell proliferation in patients with hepatocellular carcinoma (HCC)....
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IL4Rα and IL17A Blockade Rescue Autoinflammation in SOCS1 Haploinsufficiency
By inhibition of JAK-STAT signaling, SOCS1 acts as a master regulator of the cytokine response across numerous tissue types and cytokine pathways....
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NMI Functions as Immuno-regulatory Molecule in Sepsis by Regulating Multiple Signaling Pathways
Sepsis-induced tissue and organ damage is caused by an overactive inflammatory response, immune dysfunction, and coagulation dysfunction....
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LOXL1-AS1 inhibits JAK2 ubiquitination and promotes cholangiocarcinoma progression through JAK2/STAT3 signaling
This study thoroughly investigated the role of the long non-coding RNA LOXL1-AS1 in the pathogenesis of cholangiocarcinoma (CCA). Through...
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Notch3 restricts metastasis of breast cancers through regulation of the JAK/STAT5A signaling pathway
PurposeTo explore the potential role of signal transducer and activator of transcription 5A (STAT5A) in the metastasis of breast cancer, and its...
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The NF-κB Pathway: a Focus on Inflammatory Responses in Spinal Cord Injury
Spinal cord injury (SCI) is a type of central nervous system trauma that can lead to severe nerve injury. Inflammatory reaction after injury is an...
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NR1D1 suppressed the growth of ovarian cancer by abrogating the JAK/STAT3 signaling pathway
BackgroundNuclear receptor subfamily 1 group D member 1 (NR1D1), a nuclear receptor associated with a variety of physiological processes, has a low...
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Role of Hippo pathway dysregulation from gastrointestinal premalignant lesions to cancer
BackgroundFirst identified in Drosophila melanogaster , the Hippo pathway is considered a major regulatory cascade controlling tissue homeostasis and...
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Increased expression of miR-194-5p through the circPVRL3/miR-194-5p/SOCS2 axis promotes proliferation and metastasis in pancreatic ductal adenocarcinoma by activating the PI3K/AKT signaling pathway
BackgroundMicroRNAs (miRNAs), as an indispensable type of non-coding RNA (ncRNA), participate in diverse biological processes. However, the specific...
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The circadian clock circuitry modulates leukemia initiating cell activity in T-cell acute lymphoblastic leukemia
BackgroundT-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy, characterized by restricted cellular subsets with...
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Comprehensive analysis of suppressor of cytokine signaling proteins in human breast Cancer
BackgroundAbnormal expression of suppressor of cytokine signaling (SOCS) proteins regulates tumor angiogenesis and development in cancers. In this...
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Signaling Regulation of Human MSC Osteogenic Differentiation: Metanalysis and Bioinformatic Analysis of MicroRNA Impact
Numerous experimental data shows crucial involvement of mirs in skeletal development in embryos, osteogenic differentiation, and maturation. However,...
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ABBV-744 alleviates LPS-induced neuroinflammation via regulation of BATF2-IRF4-STAT1/3/5 axis
Suppression of neuroinflammation using small molecule compounds targeting the key pathways in microglial inflammation has attracted great interest....
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Discovery of a novel and highly selective JAK3 inhibitor as a potent hair growth promoter
JAK-STAT signalling pathway inhibitors have emerged as promising therapeutic agents for the treatment of hair loss. Among different JAK isoforms,...
