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Preparation and Evaluation of Berberine-Excipient Complexes in Enhancing the Dissolution Rate of Berberine Incorporated into Pellet Formulations
Berberine is used in the treatment of metabolic syndrome and its low solubility and very poor oral bioavailability of berberine was one of the...
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Gene silencing in the aedine cell lines C6/36 and U4.4 using long double-stranded RNA
BackgroundRNA interference (RNAi) is a target-specific gene silencing method that can be used to determine gene functions and investigate...
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Invasion and Metastatic Potential of Cancer Stem Cells In Vitro
In order to fight against cancer, it is critical to study cellular migration, invasion, and adhesion, which are the pivotal steps of metastasis....
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Redirecting Human Conventional and Regulatory T Cells Using Chimeric Antigen Receptors
The adaptive immune system exhibits exquisite specificity and memory and is involved in virtually every process in the human body. Redirecting...
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Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity
BackgroundPericytes are a vital component of the blood–brain barrier, and their involvement in acute inflammation was recently suggested. However, it...
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An Optimized Protocol of Electroporation of Hepatocyte Nuclear Factor 1 Alpha (Hnf-1α) in Mesenchymal Stem Cells
AbstractThe objective of this study was to investigate the optimization of electroporation of hepatocyte nuclear factor 1 alpha ( Hnf-1 α) in murine...
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Dexamethasone Degradation in Aqueous Medium and Implications for Correction of In Vitro Release from Sustained Release Delivery Systems
The in vitro drug release in an aqueous medium is a critical performance metric for a sustained release drug product. During long-term release...
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Profiling Complex RAS-Effector Interactions Using NMR Spectroscopy
Knowledge of how effectors interact with RAS GTPases is key to understanding how these switch-like proteins function in cells. Effectors bind...
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Neuroinflammation driven by human immunodeficiency virus-1 (HIV-1) directs the expression of long noncoding RNA RP11-677M14.2 resulting in dysregulation of neurogranin in vivo and in vitro
Neuroinflammation and synaptodendritic damage represent the pathological hallmarks of HIV-1 associated cognitive disorders (HAND). The post-synaptic...
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Use of Affinity Purification–Mass Spectrometry to Identify Phosphorylated Tau Interactors in Alzheimer’s Disease
Phosphorylated tau is the main protein present in neurofibrillary tangles, the presence of which is a key neuropathological hallmark of Alzheimer’s...
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Insights into the protective immune response by immunization with full-length recombinant TprK protein: cellular and humoral responses
Syphilis has resurged in many countries, which has called attention to vaccine development. Based on the immunization-based rabbit model of infection...
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Assaying Chemical Long-Term Potentiation in Human iPSC-Derived Neuronal Networks
Impairment of long-term potentiation (LTP) is a common feature of many preclinical models of neurological disorders. Modeling LTP on human induced...
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ANKRD49 promotes the metastasis of NSCLC via activating JNK-ATF2/c-Jun-MMP-2/9 axis
BackgroundAnkyrin repeat domain 49 (ANKRD49) has been found to be highly expressed in multiple cancer including lung adenocarcinoma (LUAD) and lung...
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Yeast Surface Display Methodology for the Characterization of Food Allergens In Situ
High throughput allergen characterization is often based on phage display technique which is limited by the constraints of a prokaryotic expression...
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Generating Homogeneous Brain Organoids from Human iPSCs
There is a high demand for the development of in vitro models for human brain development and diseases due to the inaccessibility of human brain...
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Evaluation of New Components in Modified Scholten’s Medium for the Detection of Somatic Coliphages
Enteric bacteriophages (somatic coliphages, F-specific coliphages or both together) are now recognized as useful viral indicators in water,...
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Isolation and Purification of Self-Renewable Human Neural Stem Cells from iPSCs for Cell Therapy in Experimental Model of Ischemic Stroke
Neural stem cell therapy has been galvanized by the discovery of pluripotent stem cells. The possibility to generate specialized central nervous...
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Syngeneic Mouse Model of Glioblastoma: Intracranial Implantation of GL261 Cells
Glioblastoma (GBM) is the most aggressive and prevalent primary brain malignancy in adults. Current treatments provide limited benefit, and thus, the...
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CD276-CAR T cells and Dual-CAR T cells targeting CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models
BackgroundRhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood, whose prognosis is still poor especially for metastatic,...
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EGFR-dependent aerotaxis is a common trait of breast tumour cells
BackgroundAerotaxis, the chemotactism to oxygen, is well documented in prokaryotes. We previously reported for the first time that non-tumorigenic...
