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Proteomics study on the protective mechanism of soybean isoflavone against inflammation injury of bovine mammary epithelial cells induced by Streptococcus agalactiae
This study aimed to verify the anti-inflammatory effect of soybean isoflavones (SI) on the inflammatory response induced by Streptococcus agalactiae (
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Ramelteon Improves Post-traumatic Stress Disorder-Like Behaviors Exhibited by Fatty Acid-Binding Protein 3 Null Mice
We previously reported that fatty acid-binding protein 3 (FABP3) knockout ( Fabp3 −/− ) mice exhibit abnormal dopamine-related behaviors such as...
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Translational profiling identifies sex-specific metabolic and epigenetic reprogramming of cortical microglia/macrophages in APPPS1-21 mice with an antibiotic-perturbed-microbiome
BackgroundMicroglia, the brain-resident macrophages perform immune surveillance and engage with pathological processes resulting in phenotype changes...
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Hepatic metastasis of gastric cancer is associated with enhanced expression of ethanolamine kinase 2 via the p53–Bcl-2 intrinsic apoptosis pathway
BackgroundGastric cancer (GC) with hepatic metastasis has a poor prognosis. Understanding the molecular mechanisms involved in hepatic metastasis may...
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Transcriptome analysis of fowl adenovirus serotype 4 infection in chickens
Fowl adenovirus serotype 4 (FAdV-4) is a causative agent of inclusion body hepatitis and hydropericardium–hepatitis syndrome. These diseases cause...
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An integrative pan-cancer investigation reveals common genetic and transcriptional alterations of AMPK pathway genes as important predictors of clinical outcomes across major cancer types
BackgroundThe AMP-activated protein kinase (AMPK) is an evolutionarily conserved regulator of cellular energy homeostasis. As a nexus for transducing...
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Interaction between CD36 and FABP4 modulates adipocyte-induced fatty acid import and metabolism in breast cancer
Adipocytes influence breast cancer behaviour via fatty acid release into the tumour microenvironment. Co-culturing human adipocytes and breast cancer...
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Prevotella copri increases fat accumulation in pigs fed with formula diets
BackgroundExcessive fat accumulation of pigs is undesirable, as it severely affects economic returns in the modern pig industry. Studies in humans...
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Exchange protein directly activated by cAMP (Epac) 1 plays an essential role in stress-induced exercise capacity by regulating PGC-1α and fatty acid metabolism in skeletal muscle
Exchange protein directly activated by cAMP (Epac) mediates cAMP-mediated cell signal independent of protein kinase A (PKA). Mice lacking Epac1...
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Circadian modulation of the cardiac proteome underpins differential adaptation to morning and evening exercise training: an LC-MS/MS analysis
All living beings on earth are influenced by the circadian rhythm, the rising and the setting of the sun. The ubiquitous effect of exercise is widely...
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Insulin treatment improves liver histopathology and decreases expression of inflammatory and fibrogenic genes in a hyperglycemic, dyslipidemic hamster model of NAFLD
BackgroundNon-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are highly prevalent comorbidities in patients with Type...
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Transcription factors in ferroptotic cell death
Ferroptosis, a form of regulated cell death, is characterized by an excessive degree of iron accumulation and lipid peroxidation. Although it was...
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Elucidating the processes and pathways enriched in buffalo sperm proteome in regulating semen quality
Sperm carries a reservoir of proteins regulating the molecular functions to attain functional competence. Semen samples collected from buffalo bulls...
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Effect of carbohydrate–protein supplementation on endurance training adaptations
PurposeTo examine the influence of post-exercise protein feeding upon the adaptive response to endurance exercise training.
MethodsIn a randomised...
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Promising biomarkers and therapeutic targets for the management of Parkinson's disease: recent advancements and contemporary research
Parkinson’s disease (PD) is one of the progressive neurological diseases which affect around 10 million population worldwide. The clinical...
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Current basis and future directions of zebrafish nutrigenomics
This review investigates the current state of nutrigenomics in the zebrafish animal models. The zebrafish animal model has been used extensively in...
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Pathophysiological implications of hypoxia in human diseases
Oxygen is essentially required by most eukaryotic organisms as a scavenger to remove harmful electron and hydrogen ions or as a critical substrate to...
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Fatty acid binding protein 7 may be a marker and therapeutic targets in clear cell renal cell carcinoma
BackgroundTo identify potential therapeutic target in clear cell renal cell carcinoma (ccRCC), we performed a transcriptome analysis. Our analysis...
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Biomarkers for Muscle Disease Gene Therapy
Molecular biomarkers are becoming increasingly attractive in drug development programs for muscle diseases especially for Duchenne muscular dystrophy...