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Early Differential Diagnosis and Restorative Treatment of Patients with Cerebral Palsy
This article addresses an urgent problem – the early diagnosis and comprehensive rehabilitation therapy of patients with cerebral palsy (CP). The...
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Potential Biomarkers for Early Diagnosis of Alzheimer’s Disease and Primary Open-Angle Glaucoma
Alzheimer’s disease (AD) is a progressive neurodegenerative disease in which the clinical picture, in addition to cognitive and behavioral disorders,...
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Symptomatic presentation of cervical cancer in emergency departments in California
PurposeThrough screening and HPV vaccination, cervical cancer can mostly be prevented or detected very early, before symptoms develop. However,...
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Early-life interactions between the microbiota and immune system: impact on immune system development and atopic disease
Prenatal and early postnatal life represent key periods of immune system development. In addition to genetics and host biology, environment has a...
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Multilevel thoracic and lumbar ligamentum flavum ossification in an achondroplasic—a rare presentation
IntroductionAchondroplasia is a rare autosomal dominant condition characterized by stenosis in spinal canal. Multilevel Ossification of the...
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Serum neurofilament light chain and initial severity of neurological disease predict the early neurological deterioration in Wilson’s disease
BackgroundIn Wilson’s disease (WD), early neurological deterioration after treatment initiation is associated with poor outcomes; however, data on...
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Genetic variation and pesticide exposure influence blood DNA methylation signatures in females with early-stage Parkinson’s disease
Although sex, genetics, and exposures can individually influence risk for sporadic Parkinson’s disease (PD), the joint contributions of these factors...
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Clinicopathological characteristics and eligibility for adjuvant olaparib of germline BRCA1/2 mutation carriers with HER2-negative early breast cancer
Following the survival benefit demonstrated in the OlympiA trial, one year of adjuvant olaparib is now recommended for all patients with germline BRCA1/2...
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Probable Novel APP Met671Leu Mutation in a Chinese Han Family with Early-Onset Alzheimer’s Disease
Familial Alzheimer’s disease (AD) is a rare disease caused by autosomal-dominant mutations. APP (encoding amyloid precursor protein), PSEN1 (encoding...
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Systems-level profiling of early peripheral host-response landscape variations across COVID-19 severity states in an Indian cohort
Host immune response to COVID-19 plays a significant role in regulating disease severity. Although big data analysis has provided significant...
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A global multicohort study to map subcortical brain development and cognition in infancy and early childhood
The human brain grows quickly during infancy and early childhood, but factors influencing brain maturation in this period remain poorly understood....
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Early life social complexity shapes adult neural processing in the communal spiny mouse Acomys cahirinus
RationaleEarly life social rearing has profound consequences on offspring behavior and resilience. Yet, most studies examining early life development...
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Lipid Metabolism and Tumor Antigen Presentation
Tumors always evade immune surveillance and block T cell activation in a poorly immunogenic and immunosuppressive environment. Cancer cells and...
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Neurodegeneration within the rostral spinal cord is associated with brain gray matter volume atrophy in the early stage of cervical spondylotic myelopathy
Study designCase-control study.
ObjectivesInvestigating the association between neurodegeneration within rostral spinal cord and brain gray matter...
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Limitations of the human iPSC-derived neuron model for early-onset Alzheimer’s disease
Non-familial Alzheimer’s disease (AD) occurring before 65 years of age is commonly referred to as early-onset Alzheimer’s disease (EOAD) and...
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Acute limb ischemia in a cancer patient has high morbidity, high mortality, and atypical presentation: a tertiary cancer center’s retrospective study
BackgroundAcute Limb Ischemia (ALI) carries a high morbidity and mortality rate that is compounded in the cancer patient. Though it is a relatively...
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Survival outcomes following treatment delays among patients with early-stage female cancers: a nationwide study
BackgroundThe coronavirus disease 2019 (COVID-19) severely hindered the timely receipt of health care for patients with cancer, especially female...
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Distinguishing features of current COVID-19 vaccines: knowns and unknowns of antigen presentation and modes of action
COVID-19 vaccines were developed with an unprecedented pace since the beginning of the pandemic. Several of them have reached market authorization...
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Employing nanoparticle tracking analysis of salivary neuronal exosomes for early detection of neurodegenerative diseases
Neurodegenerative diseases are a set of progressive and currently incurable diseases that are primarily caused by neuron degeneration....
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Very-early-onset Inflammatory Bowel Disease in an Infant with a Partial RIPK1 Deletion
The monogenic causes of very-early-onset inflammatory bowel disease (VEO-IBD) have been defined by genetic studies, which were usually related to...
