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Circulating MicroRNA (miRNA)s as Biological Markers and Links with Obesity and Obesity-Related Morbid Conditions
In late years, a substantial advance has been made in the study of the role of microRNAs (miRNAs) in the pathogenesis of diseases. New evidence shows...
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Role of Circulating MicroRNAs in Prognosis and Diagnosis of Cancers
Cancer causes a spectrum of diseases based on the nature of the human disease. The early detection of cancer is still a clinical challenge, despite...
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Is the regulation by miRNAs of NTPDase1 and ecto-5’-nucleotidase genes involved with the different profiles of breast cancer subtypes?
Breast cancer (BC) is a public health problem worldwide, causing suffering and premature death among women. As a heterogeneous disease, BC-specific...
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Crosstalk Between miRNA and Protein Expression Profiles in Nitrate-Exposed Brain Cells
Growing evidence reported a strong association between the nitrate ingestion and adverse health consequences in humans, including its detrimental...
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Mechanisms of radiotherapy resistance and radiosensitization strategies for esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is the sixth most common cause of cancer-related mortality worldwide, with more than half of them occurred...
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miR profile in pagetic osteoclasts: from large-scale sequencing to gene expression study
AbstractPaget’s disease of bone (PDB) is characterized by excessive and disorganized bone remodeling, in which bone-resorbing osteoclasts play a key...
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Hypomethylation and downregulation of miR-23b-3p are associated with upregulated PLAU: a diagnostic and prognostic biomarker in head and neck squamous cell carcinoma
BackgroundDNA methylation and miRNA-target genes play an important part in the early development of various tumors and have been studied as tumor...
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MicroRNAs Targeting Tumor Microenvironment and Immune Modulation
MicroRNAs (miRNAs) are small noncoding RNAs (~22 nucleotides) that regulate transcriptional and translational processes. In particular, miRNAs act as...
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The role of Exosomal miRNAs in cancer
Exosomal miRNAs have attracted much attention due to their critical role in regulating genes and the altered expression of miRNAs in virtually all...
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Tumor-derived small extracellular vesicles in cancer invasion and metastasis: molecular mechanisms, and clinical significance
The production and release of tumor-derived small extracellular vesicles (TDSEVs) from cancerous cells play a pivotal role in the propagation of...
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MicroRNAs as Potential Biomarkers of Type 2 Diabetes Mellitus
AbstractMicroRNAs are small noncoding RNAs involved in post-transcriptional regulation of gene expression. In recent years, works demonstrating...
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Biomarkers of malignant transformation in oral leukoplakia: from bench to bedside
Oral leukoplakia is a common precursor lesion of oral squamous cell carcinoma, which indicates a high potential of malignancy. The malignant...
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Plasma cell signatures predict prognosis and treatment efficacy for lung adenocarcinoma
PurposeThis study aims to identify key genes regulating tumor infiltrating plasma cells (PC) and provide new insights for innovative immunotherapy....
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The role of alternative pre-mRNA splicing in cancer progression
Alternative pre-mRNA splicing is a critical mechanism that generates multiple mRNA from a single gene, thereby increasing the diversity of the...
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Iron metabolism in colorectal cancer: a balancing act
BackgroundColorectal cancer (CRC) is the third most commonly diagnosed cancer and the second deadliest malignancy worldwide. Current dietary habits...
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Molecular and metabolic regulation of immunosuppression in metastatic pancreatic ductal adenocarcinoma
Immunosuppression is a hallmark of pancreatic ductal adenocarcinoma (PDAC), contributing to early metastasis and poor patient survival. Compared...
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The crosstalk between reactive oxygen species and noncoding RNAs: from cancer code to drug role
Oxidative stress (OS), characterized by the excessive accumulation of reactive oxygen species (ROS), is an emerging hallmark of cancer. Tumorigenesis...
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LINC01002 functions as a ceRNA to regulate FRMD8 by sponging miR-4324 for the development of COVID-19
BackgroundSyndrome coronavirus-2 (SARS-CoV-2) has developed various strategies to evade the antiviral impact of type I IFN. Non-structural proteins...
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Exosomal let-7a-5p derived from human umbilical cord mesenchymal stem cells alleviates coxsackievirus B3-induced cardiomyocyte ferroptosis via the SMAD2/ZFP36 signal axis
Viral myocarditis (VMC) is one of the most common acquired heart diseases in children and teenagers. However, its pathogenesis is still unclear, and...
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The role of noncoding RNAs in Parkinson’s disease: biomarkers and associations with pathogenic pathways
The discovery of various noncoding RNAs (ncRNAs) and their biological implications is a growing area in cell biology. Increasing evidence has...
