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m6A-Mediated Upregulation of lncRNA CHASERR Promotes the Progression of Glioma by Modulating the miR-6893-3p/TRIM14 Axis
Long noncoding RNAs (lncRNAs) play crucial roles in tumor progression and are dysregulated in glioma. However, the functional roles of lncRNAs in...
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Development of preoperative and postoperative models to predict recurrence in postoperative glioma patients: a longitudinal cohort study
BackgroundGlioma recurrence, subsequent to maximal safe resection, remains a pivotal challenge. This study aimed to identify key clinical predictors...
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Differentiation of glioma and solitary brain metastasis: a multi-parameter magnetic resonance imaging study using histogram analysis
BackgroundDifferentiation of glioma and solitary brain metastasis (SBM), which requires biopsy or multi-disciplinary diagnosis, remains sophisticated...
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AQP8 promotes glioma proliferation and growth, possibly through the ROS/PTEN/AKT signaling pathway
BackgroundThe aquaporin (AQP) family of proteins has been implicated in the proliferation and growth of gliomas. Expression of AQP8 is higher in...
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Extracellular vesicles released by glioma cells are decorated by Annexin A2 allowing for cellular uptake via heparan sulfate
Extracellular vesicles (EVs) play a crucial role in regulating cell behavior by delivering their cargo to target cells. However, the mechanisms...
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Chronic hypoxia remodels the tumor microenvironment to support glioma stem cell growth
Cerebral organoids co-cultured with patient derived glioma stem cells (GLICOs) are an experimentally tractable research tool useful for investigating...
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LncRNA WEE2-AS1 is a diagnostic biomarker that predicts poor prognoses in patients with glioma
BackgroundGlioma is characterized by high morbidity, high mortality, and poor prognosis. Despite tremendous advances in the treatment of glioma, the...
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Insights into the regulatory role of RNA methylation modifications in glioma
Epitranscriptomic abnormalities, which are highly prevalent in primary central nervous system malignancies, have been identified as crucial...
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Tracking tumor alteration in glioma through serum fibroblast activation protein combined with image
PurposeDetecting tumor progression of glioma continues to pose a formidable challenge. The role of fibroblast activation protein (FAP) in gliomas has...
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Localization of protoporphyrin IX during glioma-resection surgery via paired stimulated Raman histology and fluorescence microscopy
The most widely used fluorophore in glioma-resection surgery, 5-aminolevulinic acid (5-ALA), is thought to cause the selective accumulation of...
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Comparative Morphological and Molecular Genetic Characteristics of Cell and Tissue Strains of Experimental Rat Glioma 10-17-2 (Astrid-17)
In order to obtain models of gliomas of varying degrees of malignancy, we performed morphological and molecular genetic study of a tissue strain of...
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Gut microbiota mediated the individualized efficacy of Temozolomide via immunomodulation in glioma
BackgroundTemozolomide (TMZ) is the preferred chemotherapy strategy for glioma therapy. As a second-generation alkylating agent, TMZ provides...
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LncRNA SNHG25 Promotes Glioma Progression Through Activating MAPK Signaling
Numerous studies indicated that long non-coding RNAs (lncRNAs) play critical roles in glioma initiation and progression. SNHG25 is a newly identified...
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HIF-1α-mediated LAMC1 overexpression is an unfavorable predictor of prognosis for glioma patients: evidence from pan-cancer analysis and validation experiments
BackgroundLaminin subunit gamma-1 (LAMC1) is a major extracellular matrix molecule involved in the tumor microenvironment. Knowledge of the...
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Integrated bioinformatics analysis and experimental validation reveal ISG20 as a novel prognostic indicator expressed on M2 macrophage in glioma
BackgroundGlioma is the most common malignant primary brain tumor and is characterized by a poor prognosis and limited therapeutic options. ISG20...
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Integrative analysis of a novel super-enhancer-associated lncRNA prognostic signature and identifying LINC00945 in aggravating glioma progression
BackgroundSuper-enhancers (SEs), driving high-level expression of genes with tumor-promoting functions, have been investigated recently. However, the...
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Temozolomide and flavonoids against glioma: from absorption and metabolism to exosomal delivery
Patients with glioblastoma multiforme and anaplastic astrocytoma are treated with temozolomide. Although it has been demonstrated that temozolomide...
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Tumor microenvironment in a minipig model of spinal cord glioma
BackgroundSpinal cord glioma (SCG) is considered an orphan disease that lacks effective treatment options with margins that are surgically...
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The longitudinal relation between executive functioning and multilayer network topology in glioma patients
Many patients with glioma, primary brain tumors, suffer from poorly understood executive functioning deficits before and/or after tumor resection. We...
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GAS5 attenuates the malignant progression of glioma stem-like cells by promoting E-cadherin
It has been widely reported that glioma stem-like cells (GSCs) serve a crucial role in the malignant progression of glioma. In particular, recent...
