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Isolation of Human Peripheral Blood T-Lymphocytes
Peripheral blood is the most common source of T-lymphocytes for in vitro culture. Here, we present a simple and standardized method for small- or...
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A Beginner’s Guide to T Cell Development
T lymphocytes (T cells) are essential components of the adaptive immune system; they serve multiple functions in responses to pathogens and to ensure...
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Adoptive T-Cell Therapy for the Treatment of Lung Cancer
Lung cancer is an imminent health threat and the predominant cause of cancer-related fatalities worldwide. Significant advancements in identifying...
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Purification of Bone Marrow Precursors to T Cells and ILCs
T cells and innate lymphoid cells (ILCs) share expression of many key transcription factors during development and at mature stage, resulting in...
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NY-ESO-1-specific T cell receptor-engineered T cells and Tranilast, a TRPV2 antagonist bivalent treatment enhances the killing of esophageal cancer: a dual-targeted cancer therapeutic route
BackgroundEsophageal cancer (EC) is a global canker notorious for causing high mortality due to its relentless incidence rate, convoluted with...
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Clinicopathological findings, prognosis, and Epstein–Barr virus infection in rheumatoid arthritis patients with other iatrogenic immunodeficiency-associated T- and NK-cell lymphoproliferative disorders
BackgroundOther iatrogenic immunodeficiency-associated (OIIA) T- and natural killer (NK)-cell lymphoproliferative disorders (TNK-LPDs) are rare in...
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PD-1/PD-L1 axis: implications in immune regulation, cancer progression, and translational applications
The PD-1/PD-L1 axis is a complex signaling pathway that has an important role in the immune system cells. Programmed cell death protein 1 (PD-1) acts...
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Choroid plexus immune cell response in murine hydrocephalus induced by intraventricular hemorrhage
BackgroundIntraventricular hemorrhage (IVH) and associated hydrocephalus are significant complications of intracerebral and subarachnoid hemorrhage....
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Exercise 28: Induction of Apoptosis in T Lymphocytes and Detection of Apoptotic Markers
Apoptosis is a programmed cell death process that occurs in response to extrinsic and intrinsic signals that leads to cell death. Binding of Fas...
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Influence of Splenomegaly and Splenectomy on the Immune Cell Profile of Patients with Common Variable Immunodeficiency Disease
PurposeAbout 25% of patients with common variable immunodeficiency disease (CVID) have splenomegaly, necessitating sometimes splenectomy whom...
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Neuroinflammation in Alzheimer’s disease: insights from peripheral immune cells
Alzheimer’s disease (AD) is a serious brain disorder characterized by the presence of beta-amyloid plaques, tau pathology, inflammation,...
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Differential immunomodulatory effects of epirubicin/cyclophosphamide and docetaxel in breast cancer patients
BackgroundEpirubicin/cyclophosphamide (EC) and docetaxel (D) are commonly used in a sequential regimen in the neoadjuvant treatment of early,...
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Autoimmunity
Autoimmunity is a condition when the body produces autoantibodies and immunologically competent T-lymphocytes against its tissues. Conditions where...
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Neurodegenerative Disorders
This chapter deals with the most common neurodegenerative diseases: Alzheimer’s disease, Parkinson’s disease, Huntington’s disease (HD), amyotrophic...
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Correlation of Cytokine Content in the Lymph with the Morphological Parameters of the Mesenteric Lymph Nodes in Adjuvant Therapy of Experimental Breast Cancer with the Use of Fragmented Human DNA
We studied the relationship between the level of cytokines in the lymph of the thoracic duct and the morphometric parameters of the mesenteric lymph...
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T lymphocytes in the intestinal mucosa: defense and tolerance
Although lymphocytes are known to circulate throughout lymphoid tissues and blood, they also establish residency in nonlymphoid organs, most...
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Melanoma Immunotherapy
Melanoma is considered a highly immunogenic tumor due to its high level of somatic mutations and frequent expression of type I interferons. As such,...
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Newborn Screening for Severe T and B Cell Lymphopenia Using TREC/KREC Detection: A Large-Scale Pilot Study of 202,908 Newborns
Newborn screening (NBS) for severe inborn errors of immunity (IEI), affecting T lymphocytes, and implementing measurements of T cell receptor...
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Lymphocytes in tumor-draining lymph nodes co-cultured with autologous tumor cells for adoptive cell therapy
BackgroundTumor-draining lymph nodes (TDLNs) are primary sites, where anti-tumor lymphocytes are primed to tumor-specific antigens and play pivotal...
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Preclinical assessment of an anti-HTLV-1 heterologous DNA/MVA vaccine protocol expressing a multiepitope HBZ protein
BackgroundHuman T-lymphotropic virus 1 (HTLV-1) is associated with the development of several pathologies and chronic infection in humans. The...
