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Pharmacokinetic and metabolomic analyses of Mangiferin calcium salt in rat models of type 2 diabetes and non-alcoholic fatty liver disease
BackgroundNon-alcoholic fatty liver is one of the most common comorbidities of diabetes. It can cause disturbance of glucose and lipid metabolism in...
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Glutamate and Neurodegeneration in the Retina
L-glutamate is a neurotransmitter throughout the various levels of retinal neurones (photoreceptors, bipolar cells, ganglion cells) and acts at a...
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Bile salt–dependent lipase promotes the barrier integrity of Caco-2 cells by activating Wnt/β-catenin signaling via LRP6 receptor
AbstractBile salt–dependent lipase (BSDL) within intestinal lumen can be endocytosed by enterocytes and support the intestinal barrier function....
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Metagenomic insights into microbial adaptation to the salinity gradient of a typical short residence-time estuary
BackgroundMicrobial adaptation to salinity has been a classic inquiry in the field of microbiology. It has been demonstrated that microorganisms can...
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The Role of Botulinum Toxin Therapy in Joint and Bone Problems
Animal studies have shown that local injection of botulinum toxins improves pain behavior via blocking the release of pain transmitters and...
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Variation in TaSPL6-D confers salinity tolerance in bread wheat by activating TaHKT1;5-D while preserving yield-related traits
Na + exclusion from above-ground tissues via the Na + -selective transporter HKT1;5 is a major salt-tolerance mechanism in crops. Using the expression...
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Predisposition to cortical neurodegenerative changes in brains of hypertension prone rats
BackgroundSubstantial evidence suggests that hypertension is a significant risk factor for cognitive decline. However, it is unclear whether the...
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Salt-Dependent Modulation of the RNA Chaperone Activity of RNA-Binding Protein La
It is well established that the RNA-binding protein La has RNA chaperone activity. Recent work suggests that the La protein has two distinct RNA...
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Improved Pharmaceutical Properties of Honokiol via Salification with Meglumine: an Exception to Oft-quoted ∆pKa Rule
Honokiol (HK), a BCS class II drug with a wide range of pharmacological activities, has poor solubility and low oral bioavailability, severely...
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Metformin Disrupts Bile Acid Efflux by Repressing Bile Salt Export Pump Expression
PurposeThe bile salt export pump (BSEP), a key player in hepatic bile acid clearance, has been the center of research on drug-induced cholestasis....
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Modulation of Solid-State Chemical Stability of Gabapentin by Pyridinecarboxylic Acid
PurposeGabapentin (GBP) is an anticonvulsant drug with poor chemical stability that is particularly sensitive to heat and mechanical stress, which...
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Clinical Pathogenesis, Molecular Mechanisms of Gastric Cancer Development
The human pathogen Helicobacter pylori is the strongest known risk factor for gastric disease and cancer, and gastric cancer remains a leading cause...
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The Use of Global Sensitivity Analysis to Assess the Oral Absorption of Weakly Basic Compounds: A Case Example of Dipyridamole
ObjectiveTo utilize the global system analysis (GSA) in oral absorption modeling to gain a deeper understanding of system behavior, improve model...
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Screening Methods for the Evaluation of Antihypertensive Drugs
Hypertension is the most common cardiovascular disease, the prevalence of which is increasing with advancing age. The applications of experimental...
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HIV, immune activation and salt-sensitive hypertension (HISH): a research proposal
ObjectiveThe objective of this study is to quantify and compare the effect of excess dietary salt on immune cell activation and blood pressure in HIV...
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Multi-omics Analysis of Young Portulaca oleracea L. Plants’ Responses to High NaCl Doses Reveals Insights into Pathways and Genes Responsive to Salinity Stress in this Halophyte Species
Soil salinity is among the abiotic stressors that threaten agriculture the most, and purslane ( Portulaca oleracea L.) is a dicot species adapted to...
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A Novel Approach for the Availability and Ocular Delivery of Tenoxicam Potassium: Synthesis, Characterization, and In Vivo Application
Tenoxicam (TX) is a non-steroidal anti-inflammatory agent that can be used to control pain in various ophthalmic lesions like cataracts, refractive...
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Mouth rinsing and ingesting salty or bitter solutions does not influence corticomotor excitability or neuromuscular function
PurposeTo explore the effect of tasting unpleasant salty or bitter solutions on lower limb corticomotor excitability and neuromuscular function.
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