Search
Search Results
-
Develo** an Application Model for Improving Quality of Pharmaceutical Manufacturing Based on the Quality Principles – Covering Quality Improvement and Quality Assurance Audit
The term “Improvement” in this context refers to creating beneficial change and achieving unprecedented levels of performance. Quality improvement in...
-
Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2D6, CYP2C19 and non-SSRI/non-TCA antidepressants
The Dutch Pharmacogenetics Working Group (DPWG) aims to facilitate pharmacogenetics implementation in clinical practice by develo** evidence-based...
-
The Use of Microdosing for In vivo Phenoty** of Cytochrome P450 Enzymes: Where Do We Stand? A Narrative Review
Cytochrome P450 (CYP) enzymes play a central role in the elimination of approximately 80% of all clinically used drugs. Differences in CYP enzyme...
-
Dose escalation of tolinapant (ASTX660) in combination with standard radical chemoradiotherapy in cervical cancer : a study protocol for a phase 1b TiTE-CRM clinical trial (CRAIN) in UK secondary care centres
BackgroundCervical cancer is the fourth most common cancer in women, with an estimated 342,000 deaths worldwide in 2020. Current standard of care in...
-
Pharmacogenomic biomarker information on drug labels of the Spanish Agency of Medicines and Sanitary products: evaluation and comparison with other regulatory agencies
This work aimed to analyse the pharmacogenetic information in the Spanish Drug Regulatory Agency (AEMPS) Summary of Products Characteristics (SmPC),...
-
Role of vitamins in the metabolic syndrome and cardiovascular disease
The prevalence of metabolic syndrome and cardiovascular disease has increased and continues to be the leading cause of mortality worldwide. The...
-
Impact of Organ Impairment on the Pharmacokinetics of Therapeutic Peptides and Proteins
The kidneys and liver are major organs involved in eliminating small-molecule drugs from the body. Characterization of the effects of renal...
-
Thermostability of Vaccines
This chapter discusses the recommended storage conditions of prequalified vaccines. First, data from the literature on heat and freeze stability are...
-
Drug dose and animal welfare: important considerations in the treatment of wildlife
A recent article published in Parasitology Research describes the use of high-dose moxidectin (Cydectin®) by wildlife carers for the treatment of...
-
Severe malaria intervention status in Nigeria: workshop meeting report
Nigeria accounts for 39% of global malaria deaths in children under 5 years of age and the effective management of severe malaria is a health...
-
Departmental action limits for TQA energy variations defined by means of statistical process control methods
The purpose of this study is to define departmental action limits for energy percentage variation measured by means of step-wedge helical Tomotherapy...
-
Colonoscopy surveillance in Lynch syndrome is burdensome and frequently delayed
Individuals with Lynch syndrome have an increased colorectal cancer risk, hence, biennial colonoscopy surveillance is recommended. We aimed to...
-
Electrophysiological Profile of Different Antiviral Therapies in a Rabbit Whole-Heart Model
Antiviral therapies for treatment of COVID-19 may be associated with significant proarrhythmic potential. In the present study, the potential...
-
Stability of ascorbic acid in human aqueous humor
ObjectiveThe stability of ascorbic acid (AA) in the human aqueous humor (AqH) remains unclear. This study aimed to investigate the stability of AqH...
-
Venlafaxine’s therapeutic reference range in the treatment of depression revised: a systematic review and meta-analysis
IntroductionThe selective serotonin and norepinephrine reuptake inhibitor venlafaxine is among the most prescribed antidepressant drugs worldwide...
-
Antiplasmodial profile of selected compounds from Malaria Box: in vitro evaluation, speed of action and drug combination studies
BackgroundArtemisinin-based combination therapy (ACT) is used as the first-line treatment of uncomplicated malaria caused by the Plasmodium falciparum ...
-
Model-based comparison of subcutaneous versus sublingual apomorphine administration in the treatment of motor fluctuations in Parkinson’s disease
The objective of this study was to compare the effectiveness of subcutaneous (SC) and sublingual (SL) formulations of apomorphine for the treatment...
-
Motor unit firing rates increase in prepubescent youth following linear periodization resistance exercise training
PurposeThe purpose was to examine the effects of 8-weeks (3 days/week) of linear periodization resistance exercise training (RET) on neuromuscular...
-
Evaluating understandability and actionability of online education materials for home-care patients with COVID-19 in Japan
ObjectiveIn Japan, educational materials on the home care of coronavirus disease 2019 (COVID-19) were developed owing to limited access to medical...
-
A Comprehensive Review on the Effect of Natural Products on Colorectal Cancer
Purpose of ReviewThis article provides insight and information on selected natural products against colorectal cancer and its mechanism of action.
...