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A Comprehensive Review on the Effect of Natural Products on Colorectal Cancer

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Abstract

Purpose of Review

This article provides insight and information on selected natural products against colorectal cancer and its mechanism of action.

Recent Findings

Colorectal cancer (CRC) is the fourth primary occurring cancer, rectal cancer is eighth throughout the world, and both are the third most commonly occurring and deadliest cancer types around the globe. The overall CRC occurrence and mortality rates are rapidly increasing in develo** countries, and the rates are decreasing or stabilizing in developed countries due to high-fat and low-fiber diets. On the other hand, natural products are versatile molecules that possess benefits, including antioxidant, anticancer, anti-inflammatory, anti-diabetic, cardioprotective, hepatoprotective, and neuroprotective. Various signal transduction pathways contribute to the pathogenesis of CRC.

Summary

Hence, in this review, we documented the natural products against colorectal cancer and their mechanism of action that augments the signal transduction pathways that are highly dysregulated in colorectal cancer.

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  1. School of Life Sciences, B.S. Abdur Rahman Crescent Institute of Science and Technology, Seethakathi Estate, GST Road, Vandalur, Chennai, 600048, Tamil Nadu, India

    V. A. Afrose Farzana & Ashok Kumar Pandurangan

  2. Department of Botany, Government Arts and Science College, Harur, Tamil Nadu, India

    Sekar Kumaran

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A.F., S.K. wrote the manuscript. Dr. A.K.P. edited and corrected the manuscript

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Correspondence to Ashok Kumar Pandurangan.

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Afrose Farzana, V.A., Kumaran, S. & Pandurangan, A.K. A Comprehensive Review on the Effect of Natural Products on Colorectal Cancer. Curr. Pharmacol. Rep. 10, 1–11 (2024). https://doi.org/10.1007/s40495-023-00349-5

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